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Arch Dis Child Fetal Neonatal Ed. Nov 2007; 92(6): F494–F497.
Published online Apr 27, 2007. doi:  10.1136/adc.2006.107755
PMCID: PMC2675402
Zinc, copper, selenium and manganese blood levels in preterm infants
Lynne D Marriott, Keith D Foote, Alan C Kimber, H Trevor Delves, and Jane B Morgan
Lynne D Marriott*, MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, Hampshire, UK
Keith D Foote, Department of Paediatrics and Child Health, Royal Hampshire County Hospital, Winchester, Hampshire, UK
Alan C Kimber, School of Mathematics, University of Southampton, Southampton, Hampshire, UK
H Trevor Delves, Formerly of Chemical Pathology, Southampton General Hospital, Southampton, Hampshire, UK
Jane B Morgan, Formerly of School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK
Correspondence to: Lynne D Marriott
MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK; ldm@mrc.soton.ac.uk
*Previous affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU 7XH.
Accepted April 9, 2007.
Abstract
Objective
To measure the zinc, copper, selenium and manganese blood levels in a cohort of 68 preterm infants, and to establish any associations with growth and/or dietary intake.
Design
Blood samples were collected at an infant's expected date of delivery (term) and 6 months later. Serum zinc, plasma copper and whole blood manganese were analysed by atomic absorption spectrometry, plasma and red cell selenium were determined by mass spectrometry. Growth and dietary intake determinations have been previously published.
Setting
Hampshire, England.
Results
Mean (SD) birth weight of the infants was 1.47 (0.434) kg and mean gestation was 31.4 (2.9) weeks. Mean blood levels at term and 6 months were: serum zinc 12.0 (2.6) µmol/l and 13.8 (2.5) µmol/l; plasma copper 10.1 (2.6) µmol/l and 19.2 (3.6) µmol/l; plasma selenium 0.49 (0.15) µmol/l and 0.72 (0.14) µmol/l; red blood cell selenium 1.68 (0.40) µmol/l and 1.33 (0.19) µmol/l; and blood manganese 320 (189) nmol/l and 211 (68) nmol/l, respectively. There were no significant associations between levels of zinc and copper and dietary intakes of those nutrients at either age (dietary intakes of selenium and manganese were not determined). Only copper levels at term were significantly associated (r = 0.31; p = 0.05) with a growth parameter (head circumference).
Conclusion
These results provide new information about trace element status in this vulnerable population.
Articles from Archives of Disease in Childhood. Fetal and Neonatal Edition are provided here courtesy of
BMJ Group