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Arch Dis Child Fetal Neonatal Ed. Nov 2007; 92(6): F459–F464.
Published online Mar 22, 2007. doi:  10.1136/adc.2006.111765
PMCID: PMC2675392
Chest computed tomography findings in bronchopulmonary dysplasia and correlation with lung function
Bruno Mahut, Jacques De Blic, Sophie Emond, Marie‐Rose Benoist, Pierre‐Henri Jarreau, Thierry Lacaze‐Masmonteil, Jean‐François Magny, and Christophe Delacourt
Bruno Mahut, Jacques De Blic, Marie‐Rose Benoist, Service de Pneumologie et Allergologie Pédiatriques, Necker‐Enfants Malades, Paris, France
Sophie Emond, Service de Radiologie Pédiatrique, Necker Enfants Malades, Paris, France
Pierre‐Henri Jarreau, Service de Réanimation Néonatale, Cochin‐Port Royal, Paris, France
Thierry Lacaze‐Masmonteil, Service de Réanimation Néonatale, Antoine Béclère, Clamart, France
Jean‐François Magny, Service de Réanimation Néonatale, Institut de Puériculture, Paris, France
Christophe Delacourt, Service de Pédiatrie and INSERM U841, Créteil, France
Correspondence to: Christophe Delacourt
Service de Pédiatrie, Centre Hospitalier Intercommunal, 40 avenue de Verdun, 94000 Créteil, France;
Accepted March 5, 2007.
With changes in the predominant pathogenic factors in the new form of bronchopulmonary dysplasia (BPD), a different pattern of CT findings may be expected. This study aimed to (1) describe CT findings in infants with BPD and (2) correlate the CT findings with lung function abnormalities.
Study design and method
Retrospective review of 41 very low birthweight infants with BPD, who were referred for pulmonary investigations at between 10 and 20 months after birth because of persistent respiratory symptoms, and underwent CT and lung function tests.
None of the infants had normal CT findings. The most frequent abnormalities were hyperlucent areas (n = 36; 88%), linear opacities (n = 39; 95%), and triangular subpleural opacities (n = 26; 63%). Bronchiectasis was not seen. None of the CT abnormalities correlated with the maximum expiratory flow at functional residual capacity (VmaxFRC). In contrast, increased number of subpleural opacities and limited linear opacities were associated with low FRC and longer duration of neonatal oxygen exposure. The numbers of triangular subpleural opacities also correlated with duration of mechanical ventilation.
Despite advances in neonatal care, many CT findings in infants with BPD are similar to those observed in the pre‐surfactant era, and are still associated with duration of supplemental oxygen and mechanical ventilation. The absence of bronchial involvement in the present study was the most striking difference from previous studies.
Articles from Archives of Disease in Childhood. Fetal and Neonatal Edition are provided here courtesy of
BMJ Group