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Logo of gseBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleGenetics, Selection, Evolution : GSEJournal Front Page
 
Genet Sel Evol. 2008; 40(4): 359–378.
Published online Jul 15, 2008. doi:  10.1186/1297-9686-40-4-359
PMCID: PMC2674907
Individual increase in inbreeding allows estimating effective sizes from pedigrees
Juan Pablo Gutiérrez,corresponding author1 Isabel Cervantes,1 Antonio Molina,2 Mercedes Valera,3 and Félix Goyache4
1Departamento de Producción Animal, Facultad de Veterinaria, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain
2Departamento de Genética, Universidad de Córdoba, Ctra. Madrid-Cádiz, km 396a, 14071 Córdoba, Spain
3Departamento de Ciencias Agro-Forestales, EUITA, Universidad de Sevilla, Ctra. Utrera km 1, 41013 Sevilla, Spain
4SERIDA-Somió, C/Camino de los Claveles 604, 33203 Gijón (Asturias), Spain
corresponding authorCorresponding author.
Juan Pablo Gutiérrez: gutgar/at/vet.ucm.es
Received May 14, 2007; Accepted January 9, 2008.
Abstract
We present here a simple approach to obtain reliable estimates of the effective population size in real world populations via the computation of the increase in inbreeding for each individual (delta Fi) in a given population. The values of delta Fi are computed as t-root of 1 - (1 - Fi) where Fi is the inbreeding coefficient and t is the equivalent complete generations for each individual. The values of delta F computed for a pre-defined reference subset can be averaged and used to estimate effective size. A standard error of this estimate of Ne can be further computed from the standard deviation of the individual increase in inbreeding. The methodology is demonstrated by applying it to several simulated examples and to a real pedigree in which other methodologies fail when considering reference subpopulations. The main characteristics of the approach and its possible use are discussed both for predictive purposes and for analyzing genealogies.
Keywords: effective size, increase in inbreeding, overlapped generation, genetic contribution
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