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Schizophr Bull. 2009 May; 35(3): 582–595.
Published online 2009 April 8. doi:  10.1093/schbul/sbp023
PMCID: PMC2669590

Relation of Schizophrenia Prevalence to Latitude, Climate, Fish Consumption, Infant Mortality, and Skin Color: A Role for Prenatal Vitamin D Deficiency and Infections?


Previous surveys found a large (>10-fold) variation in schizophrenia prevalence at different geographic sites and a tendency for prevalence to increase with latitude. We conducted meta-analyses of prevalence studies to investigate whether these findings pointed to underlying etiologic factors in schizophrenia or were the result of methodological artifacts or the confounding of sites’ latitude with level of healthcare at those sites. We found that these patterns were still present after controlling for an index of healthcare—infant mortality—and focusing on 49 studies that used similar diagnostic and ascertainment methods. The tendencies for schizophrenia prevalence to increase with both latitude and colder climate were still large and significant and present on several continents. The increase in prevalence with latitude was greater for groups with low fish consumption, darker skin, and higher infant mortality—consistent with a role of prenatal vitamin D deficiency in schizophrenia. Previous research indicates that poor prenatal healthcare and nutrition increase risk for schizophrenia within the same region. These adverse conditions are more prevalent in developing countries concentrated near the equator, but schizophrenia prevalence is lowest at sites near the equator. This suggests that schizophrenia-producing environmental factors associated with higher latitude may be so powerful they overwhelm protective effects of better healthcare in industrialized countries. The observed patterns of correlations of risk factors with prevalence are consistent with an etiologic role for prenatal vitamin D deficiency and exposure to certain infectious diseases. Research to elucidate environmental factors that underlie variations in schizophrenia prevalence deserves high priority.

Keywords: epidemiology, etiology, immune function, prenatal, geography, risk factor


Schizophrenia is an unusually burdensome disorder because of the great economic costs of extensive care and loss of economic productivity, as well as the personal suffering and stigma, which often affect a patient and his or her family for most of the patient's life. Moreover, for most patients there is still no cure or even an effective way of treating many of the most disabling, “negative” symptoms of the disorder. Therefore, a key goal of schizophrenia research is elucidation of etiologic factors, particularly environmental ones that could be readily avoided and used in effective, inexpensive, and ethically sound primary prevention programs.

In a comprehensive survey of schizophrenia prevalence studies around the world that were published in English over a period of 4 decades, Torrey1 noted 2 important patterns. First, prevalence rates varied widely at different geographic sites, with the highest rate being more than 10 times greater than the lowest. Second, there was a strong tendency for schizophrenia prevalence to increase with increasing latitude; ie, prevalence rates tended to be very low near the equator and to increase as one moved toward the poles. Both of Torrey's conclusions were also reached in a survey and meta-analysis by Saha et al,2 which included more recent studies as well as ones published in languages other than English. Several other surveys have also concluded that schizophrenia rates vary at least 10-fold around the world, including studies using measures of point prevalence, lifetime prevalence, and incidence.1,310

A number of explanations have been proposed for this variability in prevalence. Several complementary lines of research suggest that the tendency for schizophrenia prevalence to increase with latitude and cold climate may be due, at least in part, to some underlying pre- or perinatal environmental influences. For example, several studies have reported extremely high schizophrenia prevalence rates in populations that have recently immigrated to northern Europe from Africa or the Caribbean.11,12. Moreover, these rates appear to be especially high in groups of African and Afro-Caribbean ancestry who were born in northern Europe, rather than groups born in Africa or the Caribbean.1114 These findings suggest that the risk of developing schizophrenia in these groups may be greatly increased by pre- or perinatal exposure to some adverse environmental factors that are associated with higher latitudes.

In addition, a widely replicated risk factor for schizophrenia is birth in the winter.15 The tendency for schizophrenia patients to be more likely than controls to be born in the winter, rather than other seasons, increases with latitude16 and severity of winter climate.17 This season-of-birth effect is smaller or even absent at sites near to the equator.18 Moreover, the season-of-birth effect tends to be stronger in cases of schizophrenia that lack either (a) a family history of the disorder19,20 or (b) a dysfunction in smooth pursuit eye movements, which several lines of evidence suggest is a behavioral indicator of a major susceptibility gene.21 Thus, pre- or postnatal exposure to seasonally variable environmental factors associated with latitude may contribute to schizophrenia risk.

These findings raise several important questions. One set of questions is concerned with how robust is the correlation of schizophrenia prevalence with latitude and cold climate. First, is the correlation still significant if one controls more carefully for differences among prevalence studies in diagnostic and ascertainment methods? Second, is the correlation found consistently for different continental regions? Third, do prevalence rates in different regions converge on low rates as the latitude of geographic sites approaches the equator?

A second set of questions concerns the fact that latitude and average income are highly correlated across sites because the developing countries with poorer economies and healthcare tend to be concentrated near the equator, whereas developed ones are concentrated at higher latitudes.1,2 Given that latitude, level of income, and access to healthcare are highly correlated with one another, can one discriminate their effects on schizophrenia prevalence? In other words, does the positive correlation of schizophrenia prevalence with latitude result because of the association of higher latitude with higher socioeconomic status and better healthcare—or despite it?

A third set of questions is concerned with what underlying adverse environmental variables correlated with latitude or general levels of economic development and healthcare may produce the observed correlation of schizophrenia prevalence with latitude. A large body of evidence indicates that, within the same geographic region, risk for schizophrenia is increased by pre- or perinatal exposure to a number of adverse environmental factors, including certain infectious diseases such as influenza and toxoplasmosis,2225 psychosocial stress,2628 malnutrition,29,30 and maternal obstetrical complications.31,32 Increased risk of schizophrenia is also associated with higher stillbirth and infant mortality rates that are in turn associated with poorer pre- and perinatal environments.33,34 Most of these adverse pre- and perinatal factors, as well as high infant mortality rates, are more prevalent in developing than industrialized countries. Because of that one might expect that schizophrenia prevalence rates would be higher in developing countries than in more developed ones. However, Torrey1 and Saha et al2 both found that schizophrenia prevalence rates tend to be lower in developing countries, which are concentrated at lower latitudes. One possible explanation is that there are environmental factors associated with living in a developing country that somehow protect against the development of schizophrenia.

An alternative explanation for why schizophrenia prevalence tends to be higher in industrialized countries is that 2 different sets of environmental factors contribute to schizophrenia, with one set being associated with high infant mortality and certain kinds of adverse pre- and perinatal factors, whereas the second set is associated with higher latitudes and colder climates. Both sets of adverse factors could contribute to schizophrenia, but the second set would be so powerful that their effects overwhelm the first set, so that prevalence rates are higher in developed countries at higher latitudes. If this second hypothesis is correct, then statistical analyses should reveal that latitude is a particularly strong predictor of schizophrenia prevalence. However, if one controls for latitude, then schizophrenia prevalence should tend to be higher for disadvantaged than advantaged groups.

There are a number of variables that are correlated with latitude for which prenatal exposure has been reported to be associated with higher schizophrenia prevalence. These variables include climactic variables such as mean low environmental temperature,17,35 diet,36 exposure to certain infectious diseases such as influenza and toxoplasmosis,22,25 and vitamin D deficiency.37

Influenza and toxoplasmosis are examples of infections for which prenatal exposure also appears to be more prevalent at higher latitudes. The influenza virus is known to be a central nervous system teratogen, and the virus is more contagious in cold, dry air.38 Prenatal exposure to toxoplasmosis is also an established teratogen with an affinity for the central nervous system, and prenatal exposure may be more common in colder climates because pregnant women usually become infected by contact with fecal material from house cats, which are the major vector of transmission and spend more time indoors in cold weather.25 If prenatal exposure to influenza and toxoplasmosis helps explain the high rates of schizophrenia at higher latitudes, then the effect of increasing latitude and cold on schizophrenia prevalence should also be greater for disadvantaged groups, who are more likely to live in housing that is crowded and unsanitary, as well as poorly insulated, heated, ventilated, and humidified. Disadvantaged pregnant mothers may also tend to be less likely to have the educational and economic resources to follow the recommended procedures to reduce the risk of becoming infected with influenza virus and toxoplasmosis.

Finally, McGrath37 proposed that prenatal vitamin D deficiency is an important etiologic factor in schizophrenia. In support of this prenatal “vitamin D deficiency” hypothesis, McGrath noted that this deficiency is more common at higher latitudes, particularly in winter (a season, as noted earlier, when birth is associated with an increased risk that a child will later develop schizophrenia; see Torrey et al15,34). The prevalence of vitamin D deficiency increases with latitude and cold climate because exposure of the skin to UVB radiation in sunlight is the major natural source of vitamin D, and the reduced hours and intensity of sunlight at higher latitudes make it difficult for people to generate enough vitamin D, especially in winter months.39 Cold climate is an additional risk factor for vitamin D deficiency because cold weather encourages people to spend more time indoors and wear heavier clothing, reducing both the duration and extent of skin exposure to sunlight. Regular daily exposure to direct sunlight at lower latitudes is sufficient for the generation of ample vitamin D, even for people with dark skin.39 If vitamin D deficiency is indeed an important contributor to schizophrenia, then factors other than sunshine that influence levels of vitamin D should contribute to schizophrenia prevalence primarily at sites that are at higher latitudes and/or have colder climates, where, for at least part of the year, many people do not receive enough sunlight exposure to produce adequate vitamin D.

The prenatal vitamin D hypothesis thus makes several predictions that the other hypotheses do not. In particular, it predicts (a) that schizophrenia prevalence will be associated not only with latitude, which is associated with level of exposure to sunlight, but also with several other factors that influence vitamin D levels and (b) that latitude may statistically interact with these other factors. These other factors include the following: (a) infant mortality (an index of pre- and postnatal care that is correlated with access to vitamin D in vitamin supplements and fortified foods); (b) skin color, which affects absorption of UV radiation in sunlight and the ability to synthesize vitamin D40 (ie, the darker the skin, the less vitamin D is synthesized for the same amount of sun exposure); and (c) consumption of fish, the major natural dietary source of vitamin D.

To test these hypotheses, we used data from a very large set of schizophrenia prevalence studies systematically identified by Saha et al,2 so that we could investigate several questions not examined in previous papers on schizophrenia prevalence. To reduce possible artifactual sources of differences in prevalence rates between studies, we focused our analyses on the subset of studies that used similar diagnostic and ascertainment methods.



The samples analyzed for this article were chosen from the larger list of 188 studies included in the Saha et al2 review of schizophrenia prevalence. Saha et al identified all studies that met their criteria of (a) reporting primary data on schizophrenia prevalence and (b) being published between 1965 and 2002. In order to make the prevalence rates obtained by different studies more comparable for our meta-analyses, we included only those studies that met each of 3 additional methodological criteria. The first inclusion criterion was that the prevalence rate was based on case ascertainment through community surveys. The second criterion was that the schizophrenia diagnosis was based on 1 of the 3 most widely used diagnostic systems with operationally defined criteria (DSM, ICD, or CATEGO systems). The third criterion was that the reported prevalence rate included only a diagnosis of schizophrenia proper (excluding other psychotic disorders). We focused on prevalence rates based on community surveys because these rates are likely to be more complete and comparable across studies than rates based only on hospitalization, which may be affected by a population's access to treatment. We focused on diagnoses of schizophrenia proper made using standard criteria to reduce artifactual variation in prevalence rates due to differences in investigators’ definitions of schizophrenia.

We also excluded some studies for other reasons. As discussed earlier, considerable evidence indicated that exposure to adverse environmental factors is particularly likely to increase risk for schizophrenia if exposure occurs prenatally or perinatally. Our analyses were therefore focused on investigating prenatal factors that might affect the prevalence rate in people born in each location. Consequently, we also excluded samples where it was likely that a high percentage of individuals were born outside of the study region. For this reason, in the US studies, prevalence rates for Hispanic- and Asian-American samples were excluded because in the samples studied these ethnic groups had relatively high numbers of individuals born outside the United States. A study from South Africa41 was excluded because that was the one study whose own investigators strongly indicated that the diagnoses of schizophrenia were most likely not valid; the investigators explained that after reviewing the diagnoses given by the CATEGO program, an experienced clinician concluded that the diagnoses of schizophrenia were not valid because the program did not take into account the fact that some apparent hallucinations and delusions were actually considered culturally appropriate in the population studied. When a study in a given country had published data separately for subsamples that were from sites with different latitudes and/or involved racially homogeneous subgroups, our analyses kept data on these subgroups separate, rather than using a country-wide figure that averaged across subsamples with potentially informative differences. Our analyses thus included the data for several different subsamples within the United States, as well as several different samples studied by Lehtinen et al.42 These latter samples were of particular relevance because the Lehtinen et al study was special in that the same investigative team had used the same diagnostic and ascertainment methods to obtain schizophrenia prevalence rates at 5 different sites in Finland that varied considerably in latitude.

These procedures yielded the 49 prevalence study samples that were used for most of our analyses. These 49 study samples, together with data on key study variables, are presented in table 1. We also conducted a supplementary analysis of the effect of medical and socioeconomic advantage on relative risk for schizophrenia. For this analysis, we included data from an additional 4 samples at 2 sites, as shown in table 2. All prevalence data used in our analyses were obtained from the primary source papers for the original studies.

Table 1.
Schizophrenia Prevalence and Respective Data, By Continent and Prevalence
Table 2.
Schizophrenia Prevalence in Disadvantaged vs Advantaged Groups at Different Latitudes


We used the period, rather than the lifetime or point, prevalence rate whenever it was available because this rate was available for the most studies. As Saha et al (2005) note, the period prevalence referred to the proportion of individuals in a sample who present with a given disorder during a specified period, typically 1 year.2 Our index of cold climate was the daily average minimum temperature in the coldest month of the year at the site. These data were obtained from the same Web site.76 If weather data for the specific geographic site were not available, we used data from the closest geographic site with available data. Because the peak age of onset for schizophrenia is in the early to mid-20s, and our analyses were focused on environmental factors to which a population surveyed would have pre- or postnatal exposure, we used the infant mortality rates for the period 25 years before the study was conducted, or the closest available year. The data on fish consumption for a site77 were also taken for the date 25 years prior to the time the original source study was conducted or the next earliest year for which data were available. For some sites, data on fish consumption at that time period were available only for the country as a whole, rather than for specific regions within the country. When other information was available on regional differences in fish consumption, that information was used to proportionally adjust consumption figures to reflect those regional differences, such as the fact that research indicates that fish consumption is significantly higher at coastal than inland regions.78,79 For correlational and general linear model (GLM) data analyses, the quantitative score for fish consumption in each sample was used, but for clarity in graphic presentations, sites were divided into 3 groups: “low” fish consumption was considered to be <5 kg/person/year; “moderate” consumption to be 5–23 kg/person/year, and “high” consumption to be >23 kg/person/year (the latter sites were islands, seaports, or a fishing village).

For our index of socioeconomic and healthcare advantage, we chose a variable, the infant mortality rate, that (a) would not change as a result of the individual's developing psychiatric symptoms and (b) would tend to reflect the average health, nutritional, and economic conditions to which individuals in a population would have been exposed during pre- and perinatal development. For correlational and GLM data analyses, we used the continuous measure of infant mortality scores. However, for simplicity in graphic presentations and for delineating some subgroups, samples were considered to be relatively medically and economically disadvantaged if they were (a) from countries with a high infant mortality rate at the time most subjects in a study's sample were born or (b) from industrialized countries with low infant mortality but belonged to an ethnic minority group that had been for generations economically and medically relatively disadvantaged, with high infant mortality rates. Thus, all but one of the sites from East Asia (from Hong Kong, Japan, Korea, Taiwan, and Xinjin, China) were considered more medically advantaged than those from South Asia (from several sites in India as well as Jakarta, Indonesia), because of higher infant mortality rates at the South Asian sites. In North America, Native American and African American samples were considered more disadvantaged than other samples because those 2 minority groups had consistently high infant mortality rates over a period of many decades.80

Infant mortality rates were obtained from the United Nations81 or other government publications.8086 Skin color was classified as dark for African Americans and groups from sub-Saharan Africa and southern India; light for groups of European ancestry; and intermediate for all other groups, such as East Asians.40

For tests of hypotheses, we calculated Pearson product-moment correlations between prevalence rates and various predictor variables, once for all samples, and again separately for major subgroups of samples. We used GLM procedures to test for main effects and hypothesized statistical interactions. The analyses did not weight samples by their size, as the size was so large for a few samples that weighting would have resulted in a small number of studies overly dominating the results. We used linear models for hypothesis tests because the hypotheses did not make strong predictions about nonlinear relationships. Statistical analyses were conducted with SAS, version 9.1 (Cary, NC).


Schizophrenia Prevalence Varies Greatly (>10-fold) Across Different Sites

As was previously found by Torrey1 and Saha et al,2 schizophrenia prevalence across all 49 samples varied widely (>10-fold) across different sites, from a high of 28 cases per 1000 at Oxford Bay, Canada, near the Arctic Circle,68 to a low of 0.9 per 1000 at 2 sites near the equator: Accra, Ghana,46 and a slum in Jakarta, Indonesia.58 The tendency for schizophrenia prevalence to vary widely across different geographic sites was robust as schizophrenia prevalence also varied widely (>5-fold) across samples within each of the 4 continents for which data were available on multiple sites (Africa, Asia, Europe, and North America). It is notable that this wide range in prevalence occurred even though in our analyses we restricted the studies to those that had used similar methods for the ascertainment and diagnosis of schizophrenia. The prevalence rates for different sites are shown in table 1 and figure 1.

Fig. 1.
Schizophrenia Prevalence and Latitude by Continent and Infant Mortality.

Prevalence Increases With Latitude and Colder Climate

Also consistent with the conclusions of Torrey1 and Saha et al,2 our analyses shown in table 3 found a strong tendency for prevalence to increase with latitude. We also found a similar tendency for prevalence to increase with cold winter climate, which is correlated with latitude. These patterns are evident in figure 1 and table 3. For all 49 samples, the correlations of prevalence with latitude (r = .46) and mean low temperature (r = −.60) are both significant (P < .001 in each case). This tendency for prevalence to increase with latitude and cold climate is also robust: it is present in each of the 6 major continental and demographic groups for which there are at least 3 different geographic sites. As figure 1 shows, the slopes of the best-fit linear regression lines are positive for all 6 subgroups, and the slopes are steepest for subgroups that have more sites at higher latitudes. The 6 subgroup correlations with prevalence ranged from r = .51 to .94 for latitude and from r = −.51 to −.99 for mean low temperature. Thus, for each continent and demographic subgroup, the correlations are consistently in the same direction, and for several continents the correlations are significant, even though the number of samples within each continent is modest so that statistical power is relatively weak.

Table 3.
Correlations of Schizophrenia Prevalence with Predictor Variables

Prevalence Is More Strongly Associated With Latitude and Climate Than With Infant Mortality

While higher latitude and colder climate are both strongly associated with higher prevalence, infant mortality rates showed a much weaker association with prevalence. In a GLM analysis, the effect of latitude for all 49 sites was highly significant (for type I sum of squares, df = 48; F = 13.27; P = .0007), but neither the main effect of infant mortality nor its interaction with latitude was significant. In addition, table 3 shows that while, as just noted, for all 49 sites the correlations of schizophrenia prevalence with both latitude and low temperature are highly significant (P < .001 in each case), the correlation with infant mortality is not significant at the .05 level. Moreover, the direction (sign) of the respective correlations of prevalence with latitude and cold are consistent across all continents and subgroups. In contrast, the direction of the correlation of prevalence with infant mortality is inconsistent across different continents.

The best-fit regression lines in figure 1 also suggest that the increase in prevalence with increasing latitude occurs despite the fact that countries at higher latitudes tend to have lower infant mortality rates. This is indicated by the finding that, for sites with higher infant mortality rates, the best-fit regression lines are displaced upward compared with the regression line for sites in the same continent that have lower infant mortality rates. In other words, at the same latitude, prevalence tends to be higher for sites with higher infant mortality. It is also notable that prevalence rates near the equator— eg, in a particularly disadvantaged region of Jakarta,58 or in poor African cities such as Accra, Ghana,46 and Addis Ababa, Ethiopia45—are extremely low, even though these tropical sites have very high infant mortality rates.

The Increase in Prevalence With Latitude Is Greater for Disadvantaged Groups

A complementary analysis used a different approach to examine whether the tendency for prevalence to increase with latitude occurs because, or in spite of, the fact that sites at higher latitudes tend to be relatively advantaged and have lower infant mortality rates. To investigate this question, we examined how the ratio of schizophrenia prevalence in disadvantaged vs advantaged samples changed as latitude increased. For this analysis, we were able to identify 5 geographic sites (see table 2) for which comparable prevalence data based on the same methods were available on both disadvantaged and advantaged samples. That is, for each of these sites, prevalence rates had been assessed at the same site by the same investigators using the same diagnostic criteria and ascertainment methods in community surveys at a similar time period—once for a more advantaged sample and once for a less advantaged sample. At each site, we calculated the relative risk or ratio of the schizophrenia prevalence in the disadvantaged to that in the advantaged group. (That is, a relative risk greater than 1.0 indicates that the prevalence rate at a given site was higher in the disadvantaged than in the advantaged group.) For this analysis, we included 2 studies—by Roy et al87 and Rin et al88—because, even though they had not used one of the standard diagnostic systems used in the other 49 studies, they had used the same diagnostic methods in comparing prevalence rates for advantaged and disadvantaged groups at the same site. (It should be noted that for this one analysis, it is likely to be misleading to compare absolute prevalence rates between different sites because for this analysis we included some studies that had used different diagnostic methods at different sites).

For this one analysis, we wanted to examine whether or not schizophrenia prevalence would be higher in medically disadvantaged than advantaged groups when controlling for latitude, climate, and study methods. In fact, for 4 of the 5 sites, the relative risk was higher for the disadvantaged groups, significantly so at 3 of the sites (see table 2). Even more noteworthy was a strong tendency for the relative risk to increase with latitude. Although this tendency should be viewed with caution, because it only involves studies at 5 different geographic sites, the strength of this tendency is reflected in a linear correlation of latitude with relative risk for schizophrenia at the 5 sites that is large, positive, and significant (r = .98, df = 4, P < .01).

The Increase in Prevalence With Latitude Is Greater for Groups With Low Fish Consumption

A GLM analysis of data for the 48 samples with data available on fish consumption found that for type I sum of squares there were significant main effects on prevalence of both latitude (df = 47; F = 9.01; P = .004) and fish intake (F = 4.56; P = .038), though the interaction did not reach significance at the .05 level. However, a more sensitive test of an interaction was provided by the 9 samples from Scandinavia. The vitamin D hypothesis would predict that an interaction of latitude with fish consumption would be most evident in these Scandinavian samples, where vitamin D deficiency is a more severe problem because of the high latitude and reduced sunlight in winter, so that dietary vitamin D intake would be more likely to affect risk for schizophrenia. In fact, for the Scandinavian sample, there was a significant interaction of latitude with fish consumption (df = 8; F = 11.8; P = .02), as well as significant main effects for latitude (F = 35.0; P = .002) and fish intake (F = 107.0; P < .0001).

Figure 2 illustrates this tendency for fish consumption to interact with latitude, in that the best-fit regression lines have a steeper slope for the sites with lower fish intake. Figure 2 also shows that this effect is particularly pronounced for the Scandinavian samples, where the slope is much steeper for the sites with lower fish consumption.

Fig. 2.
Schizophrenia Prevalence and Latitude by Fish Intake.

The Increase in Prevalence Is Greater for Groups With Dark Skin

A GLM analysis of latitude and skin color found that for all sites there were significant main effects for both latitude (df = 47; F = 15.74; P = .0003) and skin color (F = 13.70; P = .0006), but the interaction was not significant at the .05 level. Figure 3 displays visually how skin color combines with latitude in predicting schizophrenia prevalence. Prevalence increases with latitude for samples with darker skin color as well as those with intermediate and lighter skin. However, the regression lines are displaced upward for the samples with darker skin; that is, at the same latitude, prevalence tends to be higher for samples with darker skin. The figure and the data in table 1 also show that darker skin, by itself, is not sufficient to produce a high prevalence because groups in southern India54,55 as well as Africans living near the equator tend to have very low prevalences.

Fig. 3.
Schizophrenia Prevalence and Latitude by Skin Color.


Our results suggest that the key findings from comprehensive surveys of the prevalence of schizophrenia at different sites around the world1,2 were not simply artifacts of differences in diagnostic and ascertainment methods used by different studies. Even though our analyses restricted prevalence studies to those that used more similar research methods for diagnosis and ascertainment of schizophrenia cases, our analyses also found (a) that prevalence rates varied more than 10-fold across geographic sites and (b) that prevalence increased markedly with increasing latitude.

That the correlation of schizophrenia prevalence with latitude is both robust and large, and is not due simply to between-site differences in diagnostic and ascertainment methods, is further suggested by analysis of data collected by Lehtinen et al.42 Their study is particularly informative because it is the study that best controlled for possible methodological sources of differences in prevalence at different geographic sites; the same investigative personnel, as well as the same methods, were used to obtain prevalence rates at several different sites within the same country. Those investigators studied schizophrenia prevalence at 5 different Finnish sites in the same time period, using a consistent set of diagnostic criteria and ascertainment methods, and their data showed a very high correlation of prevalence with both latitude (r = .97, P < .01) and mean low temperature (r = −.99, P < .001).

At higher latitudes, there is an especially wide variation in prevalence rates. By contrast, near the equator, prevalence for all sites tends to be quite low. That is, for all groups and continental regions for which there are data from multiple sites, the best-fit (least squares) regression lines all have positive slopes, and the slopes tend to be steeper for sites at higher latitudes. This is evident by inspecting table 1, but is most readily visualized in figure 1.

The results suggest that etiologic factors closely associated with latitude and cold climate may be much more powerful contributors to risk for schizophrenia than is generally recognized. The general level of a population's economic status and healthcare, as indexed in our analysis by the infant mortality rate, appears to be a much weaker predictor of risk for schizophrenia than are latitude and winter temperature. A high infant mortality rate was strongly associated with increased risk for schizophrenia prevalence only at higher latitudes, suggesting that better incomes and access to healthcare may affect schizophrenia prevalence primarily by their effects in moderating exposure to underlying risk factors associated with latitude and climate.

A key question then is what those underlying risk factors might be. The prenatal vitamin D deficiency and certain infectious disease hypotheses both correctly predicted that schizophrenia prevalence should increase with latitude and cold climate. These hypotheses also make additional predictions about schizophrenia. The vitamin D hypothesis, eg, correctly predicts that the increase in schizophrenia risk with latitude is greater for groups that are economically disadvantaged. Groups with poorer prenatal care are less likely to get adequate vitamin D from sources other than sunlight, such as prenatal vitamins or vitamin D enriched food; dietary vitamin D intake is important for maternal vitamin D levels only when sun exposure is insufficient to produce healthy levels of the vitamin.

The results of our analyses fit particularly well with the predictions of the prenatal vitamin D deficiency hypothesis because, as was noted in the introduction, other research suggests that the effect of latitude on risk may involve prenatal exposure to environmental factors associated with higher latitudes. The prevalence of vitamin D deficiency increases markedly at higher latitudes with reduced exposure to sunlight, and cold weather will tend to cause people to spend more time indoors and wear clothing that covers more of their skin when they are outside, thereby further reducing sunlight exposure and vitamin D production. Thus, the strong correlation of prevalence with colder climate also fits well with the vitamin D hypothesis. Our findings also suggest that lighter skin may be a protective factor against etiologic factors in schizophrenia, such as vitamin D deficiency, that are associated with higher latitudes. Other epidemiologic research is consistent with this finding. For example, Bresnahan et al89 found that, even after controlling for measures of family socioeconomic status, the prevalence of hospitalization for schizophrenia in Alameda County, CA, was significantly higher for African Americans than for whites. A meta-analysis by Cantor-Graae and Selten90 found that relative risk for developing schizophrenia was 4.8 for migrants from areas where the majority of the population was black vs those from areas where most of the population was not black.

Our results do not appear to be consistent with a role for infectious diseases in general because pre- and perinatal morbidity for many infectious diseases tends to be relatively high in poorer countries, particularly in poor urban areas that are characterized by crowding and poor hygiene. Yet as we have noted, the schizophrenia prevalence rates were particularly low for disadvantaged urban sites near the equator. Our results may, however, be consistent with a role in schizophrenia of prenatal exposure to particular infectious diseases, such as influenza and toxoplasmosis, that appear to be more prevalent at sites with colder climates. Cold weather leads people to spend more time together in close proximity indoors, and there is evidence that the influenza virus is adapted to spread more readily in cold, dry air.38 More than a dozen epidemiologic studies have reported that increased risk of schizophrenia is associated with prenatal exposure to particular infectious diseases such as toxoplasmosis25 and influenza.22,24,91 The most direct study of prenatal influenza and schizophrenia risk92 found that exposure to influenza in the first half of pregnancy was associated with a 3-fold increase in schizophrenia risk, based on data from a follow-up study of individuals who were in utero when sera were obtained from their mothers and later assayed for levels of antibodies to influenza.

Christensen and Christensen93 found that in cross-national comparisons, high consumption of seafood (which is low in saturated fat and high in omega-3 fatty acids, as well as being the most important dietary source of vitamin D39) was associated with lower schizophrenia rates. Based on this and other evidence, Mahadik36 hypothesized that prenatal deficiency of omega-3 fatty acids is a contributing factor in the development of schizophrenia because these fatty acids are essential for brain and behavioral development. Prenatal deficiency of omega-3 fatty acids has been shown to lead to reduced body and brain weight, reduced head size, and increased cognitive deficits in children. These abnormalities are more common in children who later develop schizophrenia. However, our analyses appear to offer greater support for the role of vitamin D than for omega-3 fatty acids because the association of fish consumption with prevalence was most evident at high latitude sites where populations were most likely to get inadequate vitamin-D from sunlight alone. Samples with low fish consumption nonetheless tended to have low prevalence rates, so long as they were at low latitudes—a finding that would not be expected if omega-3 consumption rather than vitamin D consumption was more important for schizophrenia prevalence.

Most hypotheses about prenatal environmental factors in schizophrenia simply predict a significant main effect—ie, that the hypothesized predictor variable, such as infant mortality or fish consumption, will be significantly correlated with schizophrenia prevalence. In contrast, the vitamin D hypothesis correctly predicted a number of different associations that were found between prevalence and several different variables, including skin color, fish consumption, and infant mortality, as well as latitude and temperature. One possible explanation for the strong correlations between latitude and cold climate with schizophrenia prevalence, and the large (>10-fold) difference in prevalence between near-Arctic and equatorial sites, may be that vitamin D deficiency has several adverse effects, each of which contributes to increased risk for schizophrenia. These multiple adverse effects may include (1) disruptive effects on prenatal brain development94 as well as (2) harmful effects on maternal immune function that make the pregnant mother and her fetus or young infant more vulnerable to prenatal exposure to infections, thereby interacting synergistically with infections, such as influenza22,92 or toxoplasmosis,25,95,96 that previous research has linked to schizophrenia. Cannell et al97 reviewed evidence indicating that vitamin D is important for several aspects of immunological defense against infectious diseases and that seasonal variation in vitamin D deficiency may explain the marked seasonality of epidemic influenza. Moreover, as McGrath98 noted, both animal and in vitro experiments have demonstrated that administration of vitamin D can inhibit the intracellular growth of Toxoplasma gondii.

The prevalence of a disease reflects factors such as remission and chronicity as well as incidence, and latitude appears to be more strongly correlated with the prevalence than the incidence of schizophrenia.6 Might vitamin D deficiency contribute to schizophrenia prevalence by increasing the chronicity of the disorder as well as its incidence? It is possible that prenatal vitamin deficiency might disrupt prenatal brain development in a way that leads to more chronic forms of schizophrenia. In addition, it is noteworthy that vitamin D is crucial for immune function throughout postnatal life as well as during prenatal development, eg, by helping to promote innate immune responses and prevent autoimmune disorders.99 Thus, it is conceivable that postnatal vitamin D deficiency could increase the chronicity as well as the incidence of schizophrenia, by weakening the immune system and its ability to fight off any postnatal infections or immune disorders that may contribute to schizophrenia.

Our results complement several other lines of research on risk factors for schizophrenia. For example, in his survey of international prevalence studies, Torrey1 found several patterns that were consistent with those we found in our analyses, even for those studies that we excluded because of differences in diagnostic and ascertainment methods. Thus, Torrey also found extremely high prevalence rates at sites that are at high latitudes, such as those in Finland and other sites in northern Scandinavia, and extremely low rates at sites near the equator, such as Java and New Guinea.

Gupta100 undertook a preliminary investigation of environmental factors that may predict the observed patterns of schizophrenia prevalence. He analyzed data on samples that had been previously ascertained as part of a World Health Organization international program of research on schizophrenia prevalence.101 Gupta found that both schizophrenia risk and a more chronic course of illness were positively correlated with several variables, including mean daily environmental temperature, infant mortality rate, and high consumption of animal fat. However, as Gupta noted, data for his analyses were available for only a dozen or fewer sites, and the different predictor variables were themselves highly intercorrelated and confounded, making it difficult to discriminate which variables might actually be contributing to increased risk for schizophrenia. In the present article's analyses, we were better able to separate the effects of these different variables because we examined data on a much larger set of schizophrenia prevalence studies than Gupta was able to.

The tendency for schizophrenia patients to be more likely than people in the general population to have been born in winter months appears to have declined in recent decades in some industrialized countries.102 Overall incidence rates for schizophrenia in northern Europe may also have declined over recent decades.103,104 This decline in schizophrenia incidence has paralleled declines in infant mortality rates, as would be expected if improved standards of nutrition and healthcare protected mothers and young infants against adverse pre- and perinatal environmental hazards, such as vitamin D deficiency, that may contribute to schizophrenia. A possible etiologic role of temperature extremes is suggested by associations of high infant mortality rates with low winter temperature and by correlations of infant mortality and stillbirth rates with schizophrenia prevalence rates at the same site.34 If winter weather near birth is in fact a risk factor for schizophrenia, then overall schizophrenia prevalence rates should be especially high in regions with higher latitudes and more severe winters, as our analyses indicate is the case.

An important caveat in interpreting the results of our analyses is that the number of studies available was often modest, especially for analyses that involved studies within the same continent, where the correlations observed sometimes depended on extreme values at only a few sites. Our results should thus be viewed with caution until they can be replicated on new and larger international epidemiological studies. While such studies may be costly and time consuming to conduct, the large effect sizes found in our analyses suggest that these could be highly cost effective because the underlying causal variables could be important contributors to schizophrenia.

Another limitation of the present study was its use of ecologic analyses. That is, the analyses involve comparisons of characteristics of groups rather than individuals. The use of data aggregated over groups and the associated loss of information about within-group variability can potentially result in important biases.105 Research is therefore needed that contains data on key variables such as prenatal vitamin D at the individual level in people with schizophrenia and in control samples. Of particular interest, eg, would be studies of whether serum levels of vitamin D in women at different periods of their pregnancies are associated with their offspring's risk for schizophrenia proper and/or with risk for traits that are known to be associated with risk for schizophrenia. A pioneering study by McGrath et al106 using this research design with samples of modest size found evidence that increased risk for schizophrenia in offspring was associated with prenatal exposure to particularly low serum levels of maternal vitamin D in African Americans. More research of this kind is needed, using samples that are larger, come from diverse geographic regions, and contain data on other potential etiologic factors such as prenatal exposure to influenza and toxoplasmosis, as well as to maternal vitamin D levels. Analyses of this kind should be considered as part of future prospective longitudinal studies of large cohorts.

In summary, our results suggest that underlying environmental factors associated with higher latitudes and colder climate may be powerful contributors to schizophrenia—so powerful that they overwhelm the protective effects of better prenatal healthcare and nutrition found in more developed countries that are concentrated at higher latitudes. One promising candidate for such a factor is vitamin D deficiency, acting either alone or in synergism with certain infectious diseases such as influenza and toxoplasmosis. Further, more definitive research to elucidate the possible underlying environmental factors deserves high priority because these underlying factors could potentially be modified and prove valuable in programs for primary prevention of schizophrenia.


Stanley Medical Research Foundation, the Michael Braman Pomeroy Memorial Fund, and the James Leach Memorial Fund at McLean Hospital.


We thank Dan Barch and Sharon Tramer for their help in preparing the manuscript.


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