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From:
Published online 2009 February 24. doi: 10.1186/1471-2164-10-90

Table 5

Ingenuity biological function analyses of IL-6-versus NGF-regulated genes in PC12 cells (selected)

IL-6 regulated genes in PC12 cellsNGF-regulated genes in PC12 cells
Categoryp-valueMoleculesp-valueMolecules
Sub-Category or Function annotation
Cellular Growth and Proliferation
Growth of cells2.27 × 10-4ACVR2A, AHSG, ANXA1, BCL2L11, BRCA1, CASP1, CDC42, CHRM3, CXCL10, EGR1, FGFR1, GAP43, GDF15, GHR, GRID2, HGF, IGF2R, IRF1, ITGA7, JAK2, MAP2K5, MST1, MT3, MX1, NOS3, NOS2A, PIM3, RARA, SCAMP2, SDC2, STAT1, TIMP1, VDR8.82 × 10-3ACHE, AGTR1, BDNF, BNIP3, CASP1, CD44, CHRM3, CREM, DDR1, DUSP6, FBN2, FN1, GDF15, GJB2, GRID2, MYL9, NRG1, PDIA3, PTPN11, SLC30A1, TGFB1, TPM1, VPS33B, ZMAT3
Proliferation of cells9.06 × 10-7ACVR2A, ADCYAP1, ANXA1, AVP, BCL2L11, BRCA1, CALCB, CDC42, CHRM3, CHRM4, CRYAB, CXCL10, EGR1, FGFR1, FRK, GDF15, GHR, GHRH, HGF, IGF2R, IRF1, JAG2, JAK2, KLF6, KLK8, LCN2, MAP2K5, MT3, NFIB, NOS3, NOS2A, NR3C2, PDGFA, RARA, REG1A, REG3A, RNMT, SDC2, ST6GAL1, STAT1, TIMP1, TPM3, USF1, VDR, VIPR13.82 × 10-3AGTR1, AKR1C3, BDNF, CALCA, CD44, CHRM3, DDR1, FN1, GDF15, GRK5, NPPC, NRG1, PPIA, PTPN11, TAC1, TGFB1
Cellular Movement
Cell movement2.18 × 10-8ADCYAP1, ANXA1, CASP1, CDC42, CHRM3, CHRM4, CXCL10, CXCL13, EGR1, FCGR2A, FER, FGB, FGFR1, GNAZ, GRID2, HGF, HLA-G, HSP90AB1, IGF2R, JAK2, LCN2, LGALS9, LIMS1, MAP2K5, MST1, NOS3, NOS2A, OLR1, PDGFA, RARA, REG3A, SDC2, ST6GAL1, STAT1, TIMP1, TPM3, TUBB, VDR, VIPR17.96x10-5ADAM17, AGTR1, APCS, BDNF, CALCA, CASP1, CD44, CHRM3, DDR1, FN1, GJB2, GNAZ, GRID2, LCAT, LIMS1, NAP1L4, NPPC, NRG1, PDE4B, PPIA, PTPN11, SCN2B, SELP, SLC1A3, TAC1, TGFB1, TPM1
Chemotaxis4.05 × 10-4ANXA1, CDC42, CXCL10, CXCL13, FCGR2A, FER, FGFR1, GNAZ, HGF, IGF2R, LGALS9, NOS3, VIPR16.29x10-5AGTR1, BDNF, CALCA, CD44, FN1, GNAZ, NAP1L4, PDE4B, PPIA, PTPN11, SCN2B, TAC1, TGFB1
Cell-To-Cell Signaling and Interaction
Adhesion of cells1.47 × 10-7ANXA1, CDC42, CDH17, CXCL10, EGR1, FCGR2A, FER, FEZ1, FGB, FGFR1, FGG, GRID2, HGF, IGF2R, ITGA7, JAG2, LGALS9, LIMS1, NOS3, OLR1, REG3A, SDC2, ST6GAL1, STAT1, STX4, TIMP11.34x10-4ACHE, ADAM17, CASK, CD44, CNTN4, DDR1, DLG1, FGG, FN1, GRID2, LIMS1, NRG1, PTPN11, SELP, STX4, TAC1, TGFB1, TPH1
Cell Signaling
Quantity of calcium3.25 × 10-3ADCYAP1, AVP, CHRM3, CXCL10, CXCL13, FCGR2A, GHRH, HGF, NOS3, NOS2A, VDR8.89x10-6AGTR1, BDNF, CALCA, CHRM3, FN1, GRK5, NPPC, PLD2, PPIA, PTHR1, PTPN11, SELP, TAC1, TGFB1
Production of nitric oxide1.33 × 10-3IRF1, JAK2, MST1, NOS3, NOS2A, STAT1--
Flux of calcium1.67 × 10-3ADCYAP1, ANXA1, AVP, CHRM3, CXCL10, CXCL13, FCGR2A, P2RX22.20x10-3CALCA, CHRM3, FN1, NPPC, P2RX2, PPIA, TGFB1
Cell surface receptor linked signal transduction1.45 × 10-3ACVR2A, ANXA1, CDC42, CXCL10, FCGR2A, FGFR1, ITGA7, JAK2, KLF6, LIMS1, PDGFA, PTPRD, STAT1--
Small Molecule Biochemistry
Quantity of cyclic AMP1.00 × 10-5ADCYAP1, AVP, CHRM4, CXCL10, GAP43, GHRH, GNAZ, NOS3, VIPR16.03x10-3BDNF, CALCA, GNAZ, NPPC, PTHR1
Production of cyclic AMP2.17 × 10-4ADCYAP1, AVP, GHRH, GNAZ, NOS3, NOS2A, VIPR1
Accumulation of cyclic AMP1.21 × 10-3ADCYAP1, AVP, AVPR2, CHRM3, GHRH, VIPR14.35 × 10-4CALCA, CHRM3, GRK5, PTHR1, TAC1, TGFB1
Formation of cyclic AMP1.28 × 10-4ADCYAP1, AVP, AVPR2, GHRH, GANZ7.26 × 10-4CALCA, GNAZ, PTHR1, TAC1
Release of Ca2+9.82 × 10-5ANXA1, AVP, CHRM3, FCGR2A, FGB, FGG--
Quantity of cholesterol--2.85 × 10-3ATP7B, BDNF, CALCA, GULO, LCAT
Post-Translational Modification
Modification of protein1.57 × 10-5AVP, BRCA1, CASP1, CHRM3, FCGR2A, FER, FGFR1, GRID2, HSP90AB1, HTATIP, JAK2, LHB, MST1, NOS3, NOS2A, PDGFA, PDIA2, PDP2, PIM3, PTPRD, ST6GAL1, STAT1, TGM14.47 × 10-3APCS, CASP1, CD44, CHRM3, DUSP6, FN1, GRID2, NDST1, NRG1, PDIA3, PPIA, PTPN11, RABGGTA, TAC1, UBB
Nervous system development and function
growth of neurites8.02 × 10-3ADCYAP1, CDC42, GAP43, HGF, TPM3--
survival of neurons3.60 × 10-3ADCYAP1, BCL2L11, GDF15, HGF, RARA, REG3A--
development of synapse6.57 × 10-3GRID2, NFASC--
fasciculation of axons3.14 × 10-2GAP43--
complexity of dendritic trees1.25 × 10-2HGF--
long-term potentiation of dentate gyrus1.25 × 10-2EGR1--
neurological process of synapse--1.60 × 10-4BDNF, CHRM3, CHRNB1, NRG1, PPP1R1A
synaptic transmission--2.88 × 10-4BDNF, CACNB2, CHRM3, CHRNB1, GABRG2, P2RX2, SCN2B, SLC1A1, SLC1A3
neurological process of axons, neurites--4.79 × 10-4BDNF, CNTN4, GRID2, NRG1, PDIA3, UBB
activation of nerves--7.73 × 10-4CALCA, TAC1
binding of neurites--7.73 × 10-4BDNF, CD44
size of cell body--7.73 × 10-4ACHE, BDNF
survival of neurons--8.92 × 10-4BDNF, GDF15, NRG1, PDIA3, SLC1A3, TGFB1
development of neurites--2.83 × 10-3ACHE, BDNF, GRID2, NRG1, PDIA3, PTPN11
migration of nervous tissue cell lines--3.38 × 10-3NRG1, TGFB1
proliferation of nervous tissue cell lines--6.67 × 10-3NPPC, TGFB1

-, no subcategories found in IPA Tool; p-values and gene symbols are from IPA Tool