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From:
Published online Feb 24, 2009. doi: 10.1186/1471-2164-10-90
Table 1
List of gene set regulated by IL-6 in PC12 cells
GeneAccession no.Fold changeSubcellular location
Cytokines
 chemokine ligand 13CXCL13AF04419643Extracellular Space
 chemokine ligand 10CXCL10U170357Extracellular Space
Enzymes
 cytochrome P450, 4f16CYP4F16U39207424Cytoplasm
 ceruloplasminCPAF202115191Extracellular Space
 peptidyl arginine deiminase, type IIIPADI3D88034142Cytoplasm
 acyl-CoA synthetase, member 1ACSL1D90109102Cytoplasm
 transglutaminase 1TGM1M5726393Plasma Membrane
 nitric oxide synthase 2ANOS2AU0369958Cytoplasm
 ornithine carbamoyltransferaseOTCM1126643Cytoplasm
 Similar to LysophospholipaseLOC374569AB00937237Unknown
 trehalaseTREHAF03804335Plasma Membrane
 kynureninaseKYNUU6816825Cytoplasm
 nitric oxide synthase 3NOS3AJ01111521Cytoplasm
 glycine amidinotransferaseGATMU0797114Cytoplasm
 guanine nucleotide binding protein, alpha zGNAZU7748514Plasma Membrane
 ST6 galactosamide alpha-2,6-sialyltranferase 1ST6GAL1M8314314Cytoplasm
 aldo-keto reductase, 1C1AKR1C1BAA9288312Cytoplasm
 myxovirus resistance 1MX1P205919Nucleus
 aldolase CALDOCX069843Cytoplasm
 2',5'-oligoadenylate synthetase 1OAS1Z188773Cytoplasm
 protein disulfide isomerise, A2PDIA2AAC504013Cytoplasm
 RNA (guanine-7-) methyltransferaseRNMTBAA824473Nucleus
 polymerase, alpha 2POLA2AJ245648-2Nucleus
 steroid-5-alpha-reductase, alpha 1SRD5A1J05035-2Cytoplasm
 aminolevulinate, delta-, synthase 2ALAS2D86297-3Cytoplasm
 glutathione S-transferase A3GSTA3X78847-3Cytoplasm
 UDP glycosyltransferase 8UGT8BC075069-3Cytoplasm
 cell division cycle 42CDC42U37720-4Cytoplasm
 cysteine dioxygenase, type ICDO1M35266-4Cytoplasm
 ST8 alpha-2,8-sialyltransferase 3ST8SIA3X80502-5Cytoplasm
G-protein coupled receptors
 adrenergic receptor, alpha-2BADRA2BM3206126Plasma Membrane
 arginine vasopressin receptor 2AVPR2AAB876785Plasma Membrane
 vasoactive intestinal peptide receptor 1VIPR1M86835-2Plasma Membrane
 cholinergic receptor, muscarinic 3CHRM3AB017656-3Plasma Membrane
 cholinergic receptor, muscarinic 4CHRM4M16409-10Plasma Membrane
Growth factors
 regenerating islet-derived 3 alphaREG3AL102291084Extracellular Space
 regenerating islet-derived 3 betaREG3BS43715672Extracellular Space
 growth differentiation factor 15GDF15AJ01197080Extracellular Space
 platelet-derived growth factor alphaPDGFAM2946469Extracellular Space
 nudix-type motif 6NUDT6AF18899522Extracellular Space
 jagged 2JAG2U700505Extracellular Space
 hepatocyte growth factorHGFX840464Extracellular Space
 macrophage stimulating 1MST1X95096-4Extracellular Space
Ion channels
 glutamate receptor, ionotropic, delta 2GRID2U0825691Plasma Membrane
 purinergic receptor P2XP2RX2Y1047511Plasma Membrane
Kinases
 fyn-related kinaseFRKU02888122Nucleus
 Janus kinase 2JAK2U13396120Cytoplasm
 phosphatidylinositol 4-kinase betaPI4KBD846672Cytoplasm
 pim-3 oncogenePIM3AF0866242Unknown
 fer tyrosine kinaseFERX13412-2Cytoplasm
 mitogen-activated protein kinase kinase 5MAP2K5U37462-2Cytoplasm
 fibroblast growth factor receptor 1FGFR1S54008-3Plasma Membrane
 activin receptor, type IIAACVR2AS48190-4Plasma Membrane
Nuclear receptors
 retinoic acid receptor alphaRARAU1521120Nucleus
 nuclear receptor, *C2NR3C2M360748Nucleus
 vitamin D receptorVDRJ03630-4Nucleus
Peptidases
 complement component 1sC1SD88250230Extracellular Space
 caspase 1CASP1U1464740Cytoplasm
 proteasome subunit, alpha 1PSMA1M298595Cytoplasm
 kallikrein-related peptidase 8KLK8AJ005641-5Extracellular Space
Phosphatases
 pyruvate dehydrogenase phosphatase 2PDP2AF062741-4Cytoplasm
 protein tyrosine phosphatase receptor DPTPRDU57502-9Plasma Membrane
Transcription regulators
 signal transducer and activator of transcription 1STAT1AF205604579Nucleus
 Kruppel-like factor 6KLF6AF072403249Nucleus
 HIV-1 Tat interacting proteinHTATIPAAB18236159Nucleus
 HIV enhancer binding protein 2HIVEP2D3795165Nucleus
 upstream transcription factor 1USF1U4174122Nucleus
 early growth response 1EGR1M184163Nucleus
 interferon regulatory factor 1IRF1M342533Nucleus
 signal transducer and activator of transcription 2STAT2AF2061623Nucleus
 breast cancer 1BRCA1U36475-2Nucleus
 D site of albumin promoter binding proteinDBPJ03179-2Nucleus
 nuclear factor I/BNFIBY07685-2Nucleus
 transcription elongation factor A 2TCEA2D12927-5Nucleus
Transmembrane receptors
 oxidized low density lipoprotein receptor 1OLR1AB018097587Plasma Membrane
 histocompatibility 2, Q region locus 10H2-Q10M31018160Plasma Membrane
 insulin-like growth factor 2 receptorIGF2RNM_00087639Plasma Membrane
 Fc fragment of IgG receptor IIa (CD32)FCGR2AM6436816Plasma Membrane
 growth hormone receptorGHRZ8375712Plasma Membrane
Transporters
 cadherin 17CDH17X78997273Plasma Membrane
 solute carrier family 6, member 3SLC6A3M8057090Plasma Membrane
 nucleoporin 153kDaNUP153L0682183Nucleus
 solute carrier family 9, member 2SLC9A2L1100432Plasma Membrane
 cadherin 17CDH17L4687413Plasma Membrane
 lipocalin 2LCN2X132959Extracellular Space
 syntaxin 4STX4L208213Plasma Membrane
 secretory carrier membrane protein 2SCAMP2AF2954052Cytoplasm
 solute carrier family 12, member 5SLC12A5U55816-3Plasma Membrane
 solute carrier family 30, member 2SLC30A2U50927-5Plasma Membrane
 syntaxin 5STX5U87971-8Cytoplasm
Others
 regenerating islet-derived 1 alphaREG1AJ05722796Extracellular Space
 TIMP metallopeptidase inhibitor 1TIMP1L31883210Extracellular Space
 calcitonin-related polypeptide betaCALCBM11596195Extracellular Space
 fibrinogen gamma chainFGGJ00734164Extracellular Space
 trans-golgi network protein 2TGOLN2X53565113Cytoplasm
 LIM and senescent cell antigen-like domains 1LIMS1AAA2008694Plasma Membrane
 alpha-2-HS-glycoproteinAHSGM2975880Extracellular Space
 ribosomal protein L3-likeRPL3LAAC5077760Unknown
 collagen, type IV, alpha 5COL4A5AB04135059Extracellular Space
 parvalbuminLOC4951J0270558Unknown
 YTH domain containing 1YTHDC1AF14473139Cytoplasm
 growth hormone releasing hormoneGHRHZ3409231Extracellular Space
 annexin A1ANXA1M1996729Plasma Membrane
 collagen, type XII, alpha 1COL12A1U5736226Extracellular Space
 regenerating islet-derived 3 gammaREG3GL2086924Extracellular Space
 adenylate cyclase activating polypeptide 1ADCYAP1S8351320Extracellular Space
 heat shock protein 90 kDa, alpha B 1HSP90AB1S4539220Cytoplasm
 luteinizing hormone betaLHBU2565317Extracellular Space
 galectin 5LGALS5L368628Extracellular Space
 myocilinMYOCAF0935678Cytoplasm
 prolactin family 8a81PRL8A8AB0001078Extracellular Space
 troponin C type 2TNNC2J055988Unknown
 ribosomal protein L18aRPL18AX141817Cytoplasm
 fibrinogen beta chainFGBU056756Extracellular Space
 tropomyosin 3TPM3X728594Cytoplasm
 tubulin, betaTUBBAB0116794Cytoplasm
 extracellular proteinase inhibitorEXPIX133093Extracellular Space
 growth associated protein 43GAP43M167363Plasma Membrane
 galectin 9LGALS9U727413Extracellular Space
 tubulin, alpha 4aTUBA4AM134443Cytoplasm
 BCL2-like 11BCL2L11AF1369272Cytoplasm
 integrin alpha 7ITGA7X65036-2Plasma Membrane
 syndecan 2SDC2M81687-2Plasma Membrane
 zinc finger protein 260ZNF260U56862-2Nucleus
 filamin CFLNCAF119148-3Cytoplasm
 metallothionein 3MT3S65838-3Cytoplasm
 arginine vasopressinAVPM25646-4Extracellular Space
 fasciculation and elongation protein zeta 1FEZ1U63740-4Cytoplasm
 crystallin, alpha BCRYABU04320-6Nucleus
 neurofascinNFASCU81036-7Plasma Membrane
Gene description names, gene symbols are from IPA Tool; accession numbers are from GenBank
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