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Logo of bmcgenoBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Genomics
 
BMC Genomics. 2009; 10: 96.
Published online Mar 2, 2009. doi:  10.1186/1471-2164-10-96
PMCID: PMC2657155
Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle
Wouter Coppieters,1 Ted HM Mes,2 Tom Druet,1 Frédéric Farnir,1 Nico Tamma,1 Chris Schrooten,3 Albert WCA Cornelissen,2 Michel Georges,corresponding author1 and Harm W Ploeger2
1Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège (B43), Liège, Belgium
2Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
3Holland Genetics, Arnhem, The Netherlands
corresponding authorCorresponding author.
Wouter Coppieters: wouter.coppieters/at/ulg.ac.be; Ted HM Mes: T.Mes/at/nioo.knaw.nl; Tom Druet: tom.druet/at/ulg.ac.be; Frédéric Farnir: F.Farnir/at/ulg.ac.be; Nico Tamma: Nico.Tamma/at/ulg.ac.be; Chris Schrooten: Schrooten.C/at/hg.nl; Albert WCA Cornelissen: a.w.c.a.cornelissen/at/vet.uu.nl; Michel Georges: michel.georges/at/ulg.ac.be; Harm W Ploeger: h.w.ploeger/at/vet.uu.nl
Received August 20, 2008; Accepted March 2, 2009.
Abstract
Background
Parasitic gastroenteritis caused by nematodes is only second to mastitis in terms of health costs to dairy farmers in developed countries. Sustainable control strategies complementing anthelmintics are desired, including selective breeding for enhanced resistance.
Results and Conclusion
To quantify and characterize the genetic contribution to variation in resistance to gastro-intestinal parasites, we measured the heritability of faecal egg and larval counts in the Dutch Holstein-Friesian dairy cattle population. The heritability of faecal egg counts ranged from 7 to 21% and was generally higher than for larval counts. We performed a whole genome scan in 12 paternal half-daughter groups for a total of 768 cows, corresponding to the ~10% most and least infected daughters within each family (selective genotyping). Two genome-wide significant QTL were identified in an across-family analysis, respectively on chromosomes 9 and 19, coinciding with previous findings in orthologous chromosomal regions in sheep. We identified six more suggestive QTL by within-family analysis. An additional 73 informative SNPs were genotyped on chromosome 19 and the ensuing high density map used in a variance component approach to simultaneously exploit linkage and linkage disequilibrium in an initial inconclusive attempt to refine the QTL map position.
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