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Logo of bmcgenoBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Genomics
 
BMC Genomics. 2009; 10: 42.
Published online Jan 22, 2009. doi:  10.1186/1471-2164-10-42
PMCID: PMC2654907
Positive correlation between gene coexpression and positional clustering in the zebrafish genome
Yen Kaow Ng,1 Wei Wu,2 and Louxin Zhangcorresponding author1
1Department of Mathematics, National University of Singapore, 2 Science Drive 2, Singapore 117543, Singapore
2Institute of Molecular and Cell Biology, Singapore 138673, Singapore
corresponding authorCorresponding author.
Yen Kaow Ng: matnyk/at/nus.edu.sg; Wei Wu: wwu/at/imcb.a-star.edu.sg; Louxin Zhang: matzlx/at/nus.edu.sg
Received July 4, 2008; Accepted January 22, 2009.
Abstract
Background
Co-expressing genes tend to cluster in eukaryotic genomes. This paper analyzes correlation between the proximity of eukaryotic genes and their transcriptional expression pattern in the zebrafish (Danio rerio) genome using available microarray data and gene annotation.
Results
The analyses show that neighbouring genes are significantly coexpressed in the zebrafish genome, and the coexpression level is influenced by the intergenic distance and transcription orientation. This fact is further supported by examining the coexpression level of genes within positional clusters in the neighbourhood model. There is a positive correlation between gene coexpression and positional clustering in the zebrafish genome.
Conclusion
The study provides another piece of evidence for the hypothesis that coexpressed genes do cluster in the eukaryotic genomes.
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