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Emerg Infect Dis. 1999 Nov-Dec; 5(6): 828–831.
PMCID: PMC2640808
Effectiveness of pneumococcal polysaccharide vaccine for preschool-age children with chronic disease.
A. E. Fiore, O. S. Levine, J. A. Elliott, R. R. Facklam, and J. C. Butler
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
A. E. Fiore: abf4/at/cdc.gov
Abstract
To estimate the effectiveness of pneumococcal polysaccharide vaccine, we serotyped isolates submitted to the Pneumococcal Sentinel Surveillance System from 1984 to 1996 from 48 vaccinated and 125 unvaccinated children 2 to 5 years of age. Effectiveness against invasive disease caused by serotypes included in the vaccine was 63%. Effectiveness against serotypes in the polysaccharide vaccine but not in a proposed seven-valent protein conjugate vaccine was 94%.
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