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Emerg Infect Dis. 1999 Nov-Dec; 5(6): 735–748.
PMCID: PMC2640803

Emerging infectious diseases and amphibian population declines.


We review recent research on the pathology, ecology, and biogeography of two emerging infectious wildlife diseases, chytridiomycosis and ranaviral disease, in the context of host-parasite population biology. We examine the role of these diseases in the global decline of amphibian populations and propose hypotheses for the origins and impact of these panzootics. Finally, we discuss emerging infectious diseases as a global threat to wildlife populations.

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Selected References

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  • Harvell CD, Kim K, Burkholder JM, Colwell RR, Epstein PR, Grimes DJ, Hofmann EE, Lipp EK, Osterhaus AD, Overstreet RM, et al. Emerging marine diseases--climate links and anthropogenic factors. Science. 1999 Sep 3;285(5433):1505–1510. [PubMed]
  • Anderson RM, May RM. The invasion, persistence and spread of infectious diseases within animal and plant communities. Philos Trans R Soc Lond B Biol Sci. 1986 Dec 15;314(1167):533–570. [PubMed]
  • Williams SE, Hero JM. Rainforest frogs of the Australian Wet Tropics: guild classification and the ecological similarity of declining species. Proc Biol Sci. 1998 Apr 7;265(1396):597–602. [PMC free article] [PubMed]
  • Berger L, Speare R, Daszak P, Green DE, Cunningham AA, Goggin CL, Slocombe R, Ragan MA, Hyatt AD, McDonald KR, et al. Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9031–9036. [PubMed]
  • Daszak P, Cunningham AA. Extinction by infection. Trends Ecol Evol. 1999 Jul;14(7):279–279. [PubMed]
  • Morell V. Are pathogens felling frogs? Science. 1999 Apr 30;284(5415):728–731. [PubMed]
  • Pessier AP, Nichols DK, Longcore JE, Fuller MS. Cutaneous chytridiomycosis in poison dart frogs (Dendrobates spp.) and White's tree frogs (Litoria caerulea). J Vet Diagn Invest. 1999 Mar;11(2):194–199. [PubMed]
  • Quinn TC. Global burden of the HIV pandemic. Lancet. 1996 Jul 13;348(9020):99–106. [PubMed]
  • Taylor SK, Williams ES, Thorne ET, Mills KW, Withers DI, Pier AC. Causes of mortality of the Wyoming toad. J Wildl Dis. 1999 Jan;35(1):49–57. [PubMed]
  • Groff JM, Mughannam A, McDowell TS, Wong A, Dykstra MJ, Frye FL, Hedrick RP. An epizootic of cutaneous zygomycosis in cultured dwarf African clawed frogs (Hymenochirus curtipes) due to Basidiobolus ranarum. J Med Vet Mycol. 1991;29(4):215–223. [PubMed]
  • Godfray HCJ, Briggs CJ, Barlow ND, O'Callaghan M, Glare TR, Jackson TA. A model of insect—pathogen dynamics in which a pathogenic bacterium can also reproduce saprophytically. Proc Biol Sci. 1999 Feb 7;266(1416):233–233. [PMC free article]
  • Bennett PM, Owens IPF. Variation in extinction risk among birds: chance or evolutionary predisposition? Proc Biol Sci. 1997 Mar 22;264(1380):401–408. [PMC free article]
  • Clark HF, Brennan JC, Zeigel RF, Karzon DT. Isolation and characterization of viruses from the kidneys of Rana pipiens with renal adenocarcinoma before and after passage in the red eft (Triturus viridescens). J Virol. 1968 Jun;2(6):629–640. [PMC free article] [PubMed]
  • Wolf K, Bullock GL, Dunbar CE, Quimby MC. Tadpole edema virus: a viscerotropic pathogen for anuran amphibians. J Infect Dis. 1968 Jun;118(3):253–262. [PubMed]
  • Mao J, Green DE, Fellers G, Chinchar VG. Molecular characterization of iridoviruses isolated from sympatric amphibians and fish. Virus Res. 1999 Sep;63(1-2):45–52. [PubMed]
  • Mao J, Hedrick RP, Chinchar VG. Molecular characterization, sequence analysis, and taxonomic position of newly isolated fish iridoviruses. Virology. 1997 Mar 3;229(1):212–220. [PubMed]
  • Westhouse RA, Jacobson ER, Harris RK, Winter KR, Homer BL. Respiratory and pharyngo-esophageal iridovirus infection in a gopher tortoise (Gopherus polyphemus). J Wildl Dis. 1996 Oct;32(4):682–686. [PubMed]
  • Chen ZX, Zheng JC, Jiang YL. A new iridovirus isolated from soft-shelled turtle. Virus Res. 1999 Sep;63(1-2):147–151. [PubMed]
  • Whittington RJ, Kearns C, Hyatt AD, Hengstberger S, Rutzou T. Spread of epizootic haematopoietic necrosis virus (EHNV) in redfin perch (Perca fluviatilis) in southern Australia. Aust Vet J. 1996 Mar;73(3):112–114. [PubMed]
  • Zupanovic Z, Lopez G, Hyatt AD, Green B, Bartran G, Parkes H, Whittington RJ, Speare R. Giant toads Bufo marinus in Australia and Venezuela have antibodies against 'ranaviruses'. Dis Aquat Organ. 1998 Feb 26;32(1):1–8. [PubMed]

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