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Logo of bmcmdBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Medical Genetics
 
From:
Published online 2009 January 30. doi: 10.1186/1471-2350-10-9

Table 2

SLC6A3 polymorphisms and haplotypes by body mass index

NormalUnderweight BMIOverweight BMIObese BMI

PolymorphismNNOR(95% CI)PNOR(95% CI)PNOR(95% CI)P
SLC6A3 VNTR
**459141.00(reference)5141.00(reference)2541.00(reference)
*9361121.07(0.48, 2.38)0.8703900.93(0.76, 1.13)0.4591590.80(0.62, 1.04)0.093
99670~630.81(0.56, 1.19)0.284190.47(0.27, 0.83)0.009
P for trendp = 0.246p = 0.005
*9/990.91(0.41, 2.01)0.8090.91(0.75, 1.10)0.3320.75(0.59, 0.96)0.023
Ex9-55A>G
AA49881.00(reference)5391.00(reference)2201.00(reference)
AG338142.66(1.08, 6.58)0.0343691.03(0.85, 1.25)0.7711931.34(1.04, 1.73)0.023
GG5946.12(1.66, 22.61)0.007801.25(0.86, 1.82)0.234270.99(0.60, 1.66)0.981
P for trendp = 0.003p = 0.329p = 0.152
AG/GG3.04(1.28, 7.24)0.0121.06(0.88, 1.28)0.5331.29(1.01, 1.65)0.042

Haplotype §

A-C-G-*795221.00(reference)9061.00(reference)4191.00(reference)
A-C-G-925130.44(0.13, 1.49)0.1872520.85(0.69, 1.05)0.126840.60(0.45, 0.80)0.001
A-T-T-*860~810.90(0.65, 1.25)0.529340.79(0.51, 1.23)0.298
G-C-G-*213101.84(0.83, 4.05)0.1322421.03(0.83, 1.28)0.7611241.15(0.88, 1.50)0.319
G-C-G-917371.51(0.62, 3.70)0.3692001.00(0.79, 1.26)0.988750.88(0.64, 1.20)0.408

* = an allele other than the SLC6A3*9 allele. These are largely (98.1%) the SLC6A3*10 VNTR allele.

† BMI categorized as Underweight (≤ 18 kg/m2), Normal (18–24.9 kg/m2), Overweight (25–29.9 kg/m2) or Obese (≥ 30 kg/m2).

‡ OR estimated using conditional logistic regression, conditioning on age, sex, current smoking status, number of cigarettes smoked.

§Haplotype analyses were conducted among non-Hispanic Caucasians.