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Emerg Infect Dis. 1998 Oct-Dec; 4(4): 529–537.
PMCID: PMC2640244

Ecologic studies of rodent reservoirs: their relevance for human health.


Within the past few years, the number of "new" human diseases associated with small-mammal reservoirs has increased dramatically, stimulating renewed interest in reservoir ecology research. A consistent, integrative approach to such research allows direct comparisons between studies, contributes to the efficient use of resources and data, and increases investigator safety. We outline steps directed toward understanding vertebrate host ecology as it relates to human disease and illustrate the relevance of each step by using examples from studies of hosts associated with rodent-borne hemorrhagic fever viruses.

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Selected References

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  • Sonenshine DE, Allan SA, Norval RA, Burridge MJ. A self-medicating applicator for control of ticks on deer. Med Vet Entomol. 1996 Apr;10(2):149–154. [PubMed]
  • Aubert M. Control of rabies in foxes: what are the appropriate measures? Vet Rec. 1994 Jan 15;134(3):55–59. [PubMed]
  • Linthicum KJ, Bailey CL, Davies FG, Tucker CJ. Detection of Rift Valley fever viral activity in Kenya by satellite remote sensing imagery. Science. 1987 Mar 27;235(4796):1656–1659. [PubMed]
  • Lee HW, Lee PW, Baek LJ, Song CK, Seong IW. Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg. 1981 Sep;30(5):1106–1112. [PubMed]
  • Hutchinson KL, Rollin PE, Peters CJ. Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg. 1998 Jul;59(1):58–65. [PubMed]
  • Vitullo AD, Hodara VL, Merani MS. Effect of persistent infection with Junin virus on growth and reproduction of its natural reservoir, Calomys musculinus. Am J Trop Med Hyg. 1987 Nov;37(3):663–669. [PubMed]
  • Green CA, Gordon DH, Lyons NF. Biological species in Praomys (Mastomys) natalensis (Smith), a rodent carrier of Lassa virus and bubonic plague in Africa. Am J Trop Med Hyg. 1978 May;27(3):627–629. [PubMed]
  • Levis S, Morzunov SP, Rowe JE, Enria D, Pini N, Calderon G, Sabattini M, St Jeor SC. Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis. 1998 Mar;177(3):529–538. [PubMed]
  • Mills JN, Johnson JM, Ksiazek TG, Ellis BA, Rollin PE, Yates TL, Mann MO, Johnson MR, Campbell ML, Miyashiro J, et al. A survey of hantavirus antibody in small-mammal populations in selected United States National Parks. Am J Trop Med Hyg. 1998 Apr;58(4):525–532. [PubMed]
  • LeDuc JW, Smith GA, Childs JE, Pinheiro FP, Maiztegui JI, Niklasson B, Antoniades A, Robinson DM, Khin M, Shortridge KF, et al. Global survey of antibody to Hantaan-related viruses among peridomestic rodents. Bull World Health Organ. 1986;64(1):139–144. [PubMed]
  • Mills JN, Ksiazek TG, Ellis BA, Rollin PE, Nichol ST, Yates TL, Gannon WL, Levy CE, Engelthaler DM, Davis T, et al. Patterns of association with host and habitat: antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. Am J Trop Med Hyg. 1997 Mar;56(3):273–284. [PubMed]
  • Carballal G, Videla CM, Merani MS. Epidemiology of Argentine hemorrhagic fever. Eur J Epidemiol. 1988 Jun;4(2):259–274. [PubMed]
  • Mills JN, Ellis BA, McKee KT, Jr, Calderon GE, Maiztegui JI, Nelson GO, Ksiazek TG, Peters CJ, Childs JE. A longitudinal study of Junin virus activity in the rodent reservoir of Argentine hemorrhagic fever. Am J Trop Med Hyg. 1992 Dec;47(6):749–763. [PubMed]
  • Childs JE, Korch GW, Glass GE, LeDuc JW, Shah KV. Epizootiology of Hantavirus infections in Baltimore: isolation of a virus from Norway rats, and characteristics of infected rat populations. Am J Epidemiol. 1987 Jul;126(1):55–68. [PubMed]
  • Glass GE, Childs JE, Korch GW, LeDuc JW. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect. 1988 Oct;101(2):459–472. [PMC free article] [PubMed]
  • Niklasson B, Hornfeldt B, Lundkvist A, Bjorsten S, Leduc J. Temporal dynamics of Puumala virus antibody prevalence in voles and of nephropathia epidemica incidence in humans. Am J Trop Med Hyg. 1995 Aug;53(2):134–140. [PubMed]
  • Childs JE, Krebs JW, Ksiazek TG, Maupin GO, Gage KL, Rollin PE, Zeitz PS, Sarisky J, Enscore RE, Butler JC, et al. A household-based, case-control study of environmental factors associated with hantavirus pulmonary syndrome in the southwestern United States. Am J Trop Med Hyg. 1995 May;52(5):393–397. [PubMed]
  • Greenwood RJ, Newton WE, Pearson GL, Schamber GJ. Population and movement characteristics of radio-collared striped skunks in North Dakota during an epizootic of rabies. J Wildl Dis. 1997 Apr;33(2):226–241. [PubMed]

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