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Logo of eidEmerging Infectious Diseases
Emerg Infect Dis. 1998 Apr-Jun; 4(2): 211–219.
PMCID: PMC2640148

Hospitalizations for unexplained illnesses among U.S. veterans of the Persian Gulf War.


Persian Gulf War veterans have reported a variety of symptoms, many of which have not led to conventional diagnoses. We ascertained all active-duty U.S. military personnel deployed to the Persian Gulf War (552,111) and all Gulf War era military personnel not deployed (1,479,751) and compared their postwar hospitalization records (until 1 April 1996) for one or more of 77 diagnoses under the International Classification of Diseases (ICD-9) system. The diagnoses were assembled by the Emerging Infections Program, Centers for Disease Control and Prevention, and are here termed "unexplained illnesses." Deployed veterans were found to have a slightly higher risk of hospitalization for unexplained illness than the nondeployed. Most of the excess hospitalizations for the deployed were due to the diagnosis "illness of unknown cause" (ICD-9 code 799.9), and most occurred in participants of the Comprehensive Clinical Evaluation Program who were admitted for evaluation only. When the effect of participation in this program was removed, the deployed had a slightly lower risk than the nondeployed. These findings suggest that active-duty Gulf War veterans did not have excess unexplained illnesses resulting in hospitalization in the 4.67-year period following deployment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Cotton P. Gulf War symptoms remain puzzling. JAMA. 1992 Nov 18;268(19):2619–2619. [PubMed]
  • Nicolson GL, Rosenberg-Nicolson NL. Doxycycline treatment and Desert Storm. JAMA. 1995 Feb 22;273(8):618–619. [PubMed]
  • Gray GC, Coate BD, Anderson CM, Kang HK, Berg SW, Wignall FS, Knoke JD, Barrett-Connor E. The postwar hospitalization experience of U.S. veterans of the Persian Gulf War. N Engl J Med. 1996 Nov 14;335(20):1505–1513. [PubMed]
  • Kang HK, Bullman TA. Mortality among U.S. veterans of the Persian Gulf War. N Engl J Med. 1996 Nov 14;335(20):1498–1504. [PubMed]
  • Writer JV, DeFraites RF, Brundage JF. Comparative mortality among US military personnel in the Persian Gulf region and worldwide during Operations Desert Shield and Desert Storm. JAMA. 1996 Jan 10;275(2):118–121. [PubMed]
  • Cowan DN, DeFraites RF, Gray GC, Goldenbaum MB, Wishik SM. The risk of birth defects among children of Persian Gulf War veterans. N Engl J Med. 1997 Jun 5;336(23):1650–1656. [PubMed]
  • Perkins BA, Flood JM, Danila R, Holman RC, Reingold AL, Klug LA, Virata M, Cieslak PR, Zaki SR, Pinner RW, et al. Unexplained deaths due to possibly infectious causes in the United States: defining the problem and designing surveillance and laboratory approaches. The Unexplained Deaths Working Group. Emerg Infect Dis. 1996 Jan-Mar;2(1):47–53. [PMC free article] [PubMed]
  • Magill AJ, Grögl M, Gasser RA, Jr, Sun W, Oster CN. Visceral infection caused by Leishmania tropica in veterans of Operation Desert Storm. N Engl J Med. 1993 May 13;328(19):1383–1387. [PubMed]
  • Wallace MR, Sharp TW, Romajzl PJ, Batchelor RA, Thornton SA, Longer CF, Burans JP. Malaria in Mogadishu, Somalia. Clin Infect Dis. 1993 Sep;17(3):510–511. [PubMed]
  • Brodine SK, Mascola JR, Weiss PJ, Ito SI, Porter KR, Artenstein AW, Garland FC, McCutchan FE, Burke DS. Detection of diverse HIV-1 genetic subtypes in the USA. Lancet. 1995 Nov 4;346(8984):1198–1199. [PubMed]
  • Maurice J. Russian chaos breeds diphtheria outbreak. Science. 1995 Mar 10;267(5203):1416–1417. [PubMed]

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