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Emerg Infect Dis. 1996 Oct-Dec; 2(4): 245–257.
PMCID: PMC2639916

Guarding against the most dangerous emerging pathogens.

Abstract

Control of emerging infectious diseases will be difficult because of the large number of disease-causing organisms that are emerging or could emerge and the great diversity of geographic areas in which emergence can occur. The modern view of the evolution of pathogen virulence--specifically its focus on the tradeoff between costs and benefits to the pathogen from increased host exploitation--allows control programs to identify and focus on the most dangerous pathogens (those that can be established with high virulence in human populations).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Morse SS. Emerging viruses: defining the rules for viral traffic. Perspect Biol Med. 1991 Spring;34(3):387–409. [PubMed]
  • Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis. 1995 Jan-Mar;1(1):7–15. [PMC free article] [PubMed]
  • Satcher D. Emerging infections: getting ahead of the curve. Emerg Infect Dis. 1995 Jan-Mar;1(1):1–6. [PMC free article] [PubMed]
  • York AK, Arthur JS. Reasons for placement and replacement of dental restorations in the United States Navy Dental Corps. Oper Dent. 1993 Sep-Oct;18(5):203–208. [PubMed]
  • Anderson RM, May RM. Coevolution of hosts and parasites. Parasitology. 1982 Oct;85(Pt 2):411–426. [PubMed]
  • Morens DM, Marchette NJ, Chu MC, Halstead SB. Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild dengue disease. Am J Trop Med Hyg. 1991 Nov;45(5):644–651. [PubMed]
  • Gulig PA, Doyle TJ. The Salmonella typhimurium virulence plasmid increases the growth rate of salmonellae in mice. Infect Immun. 1993 Feb;61(2):504–511. [PMC free article] [PubMed]
  • Asjö B, Morfeldt-Månson L, Albert J, Biberfeld G, Karlsson A, Lidman K, Fenyö EM. Replicative capacity of human immunodeficiency virus from patients with varying severity of HIV infection. Lancet. 1986 Sep 20;2(8508):660–662. [PubMed]
  • Cheng-Mayer C, Seto D, Tateno M, Levy JA. Biologic features of HIV-1 that correlate with virulence in the host. Science. 1988 Apr 1;240(4848):80–82. [PubMed]
  • Albert J, Böttiger B, Biberfeld G, Fenyö EM. Replicative and cytopathic characteristics of HIV-2 and severity of infection. Lancet. 1989 Apr 15;1(8642):852–853. [PubMed]
  • Fenyö EM, Albert J, Asjö B. Replicative capacity, cytopathic effect and cell tropism of HIV. AIDS. 1989;3 (Suppl 1):S5–12. [PubMed]
  • Levy JA. Human immunodeficiency viruses and the pathogenesis of AIDS. JAMA. 1989 May 26;261(20):2997–3006. [PubMed]
  • Tersmette M, Gruters RA, de Wolf F, de Goede RE, Lange JM, Schellekens PT, Goudsmit J, Huisman HG, Miedema F. Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J Virol. 1989 May;63(5):2118–2125. [PMC free article] [PubMed]
  • Tersmette M, Lange JM, de Goede RE, de Wolf F, Eeftink-Schattenkerk JK, Schellekens PT, Coutinho RA, Huisman JG, Goudsmit J, Miedema F. Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality. Lancet. 1989 May 6;1(8645):983–985. [PubMed]
  • Ma XY, Sakai K, Sinangil F, Golub E, Volsky DJ. Interaction of a noncytopathic human immunodeficiency virus type 1 (HIV-1) with target cells: efficient virus entry followed by delayed expression of its RNA and protein. Virology. 1990 May;176(1):184–194. [PubMed]
  • Schneweis KE, Kleim JP, Bailly E, Niese D, Wagner N, Brackmann HH. Graded cytopathogenicity of the human immunodeficiency virus (HIV) in the course of HIV infection. Med Microbiol Immunol. 1990;179(4):193–203. [PubMed]
  • Gruters RA, Terpstra FG, De Goede RE, Mulder JW, De Wolf F, Schellekens PT, Van Lier RA, Tersmette M, Miedema F. Immunological and virological markers in individuals progressing from seroconversion to AIDS. AIDS. 1991 Jul;5(7):837–844. [PubMed]
  • Schellekens PT, Tersmette M, Roos MT, Keet RP, de Wolf F, Coutinho RA, Miedema F. Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype. AIDS. 1992 Jul;6(7):665–669. [PubMed]
  • Hirsch I, Salaun D, Brichacek B, Chermann JC. HIV1 cytopathogenicity-genetic difference between direct cytotoxic and fusogenic effect. Virology. 1992 Feb;186(2):647–654. [PubMed]
  • Koot M, Keet IP, Vos AH, de Goede RE, Roos MT, Coutinho RA, Miedema F, Schellekens PT, Tersmette M. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med. 1993 May 1;118(9):681–688. [PubMed]
  • Connor RI, Mohri H, Cao Y, Ho DD. Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals. J Virol. 1993 Apr;67(4):1772–1777. [PMC free article] [PubMed]
  • Connor RI, Ho DD. Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J Virol. 1994 Jul;68(7):4400–4408. [PMC free article] [PubMed]
  • Fisher SG. Epidemiology: a tool for the study of human papillomavirus-related carcinogenesis. Intervirology. 1994;37(3-4):215–225. [PubMed]
  • Puel J, Izopet J, Lheritier D, Briant L, Guyader M, Tricoire J, Berrebi A. Viral load and mother-to-infant HIV transmission. Lancet. 1992 Oct 3;340(8823):859–859. [PubMed]
  • Weiser B, Nachman S, Tropper P, Viscosi KH, Grimson R, Baxter G, Fang G, Reyelt C, Hutcheon N, Burger H. Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral titer to mother-to-child transmission and stability of viral load. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8037–8041. [PubMed]
  • Kaye JN, Cason J, Pakarian FB, Jewers RJ, Kell B, Bible J, Raju KS, Best JM. Viral load as a determinant for transmission of human papillomavirus type 16 from mother to child. J Med Virol. 1994 Dec;44(4):415–421. [PubMed]
  • Adjorlolo-Johnson G, De Cock KM, Ekpini E, Vetter KM, Sibailly T, Brattegaard K, Yavo D, Doorly R, Whitaker JP, Kestens L, et al. Prospective comparison of mother-to-child transmission of HIV-1 and HIV-2 in Abidjan, Ivory Coast. JAMA. 1994 Aug 10;272(6):462–466. [PubMed]
  • Ewald PW. Waterborne transmission and the evolution of virulence among gastrointestinal bacteria. Epidemiol Infect. 1991 Feb;106(1):83–119. [PMC free article] [PubMed]
  • Kitayaporn D, Tansuphaswadikul S, Lohsomboon P, Pannachet K, Kaewkungwal J, Limpakarnjanarat K, Mastro TD. Survival of AIDS patients in the emerging epidemic in Bangkok, Thailand. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jan 1;11(1):77–82. [PubMed]
  • Learmont J, Tindall B, Evans L, Cunningham A, Cunningham P, Wells J, Penny R, Kaldor J, Cooper DA. Long-term symptomless HIV-1 infection in recipients of blood products from a single donor. Lancet. 1992 Oct 10;340(8824):863–867. [PubMed]
  • Cao Y, Qin L, Zhang L, Safrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med. 1995 Jan 26;332(4):201–208. [PubMed]
  • Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med. 1995 Jan 26;332(4):228–232. [PubMed]
  • Ewald PW. Evolution of mutation rate and virulence among human retroviruses. Philos Trans R Soc Lond B Biol Sci. 1994 Nov 29;346(1317):333–343. [PubMed]
  • House JA, Turell MJ, Mebus CA. Rift Valley fever: present status and risk to the Western Hemisphere. Ann N Y Acad Sci. 1992 Jun 16;653:233–242. [PubMed]
  • Levine PH, Manns A, Jaffe ES, Colclough G, Cavallaro A, Reddy G, Blattner WA. The effect of ethnic differences on the pattern of HTLV-I-associated T-cell leukemia/lymphoma (HATL) in the United States. Int J Cancer. 1994 Jan 15;56(2):177–181. [PubMed]
  • Franco EL, Villa LL, Ruiz A, Costa MC. Transmission of cervical human papillomavirus infection by sexual activity: differences between low and high oncogenic risk types. J Infect Dis. 1995 Sep;172(3):756–763. [PubMed]
  • Weissman JB, Marton KI, Lewis JN, Friedmann CT, Gangarosa EJ. Impact in the United States of the Shiga dysentery pandemic of Central America and Mexico: a review of surveillance data through 1972. J Infect Dis. 1974 Feb;129(2):218–223. [PubMed]
  • Dixon RE. Effect of infections on hospital care. Ann Intern Med. 1978 Nov;89(5 Pt 2 Suppl):749–753. [PubMed]
  • Haley RW, Culver DH, White JW, Morgan WM, Emori TG. The nationwide nosocomial infection rate. A new need for vital statistics. Am J Epidemiol. 1985 Feb;121(2):159–167. [PubMed]
  • Raju TN, Kobler C. Improving handwashing habits in the newborn nurseries. Am J Med Sci. 1991 Dec;302(6):355–358. [PubMed]
  • Pittet D, Wenzel RP. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med. 1995 Jun 12;155(11):1177–1184. [PubMed]
  • BELNAP WD, O'DONNELL JJ. Epidemic gastroenteritis due to Escherichia coli 0-111; a review of the literature, with the epidemiology, bacteriology, and clinical findings of a large outbreak. J Pediatr. 1955 Aug;47(2):178–193. [PubMed]
  • ROUNTREE PM, FREEMAN BM. Infections caused by a particular phage type of Staphylococcus aureus. Med J Aust. 1955 Jul 30;42(5):157–161. [PubMed]
  • Jessen O, Rosendal K, Bülow P, Faber V, Eriksen KR. Changing staphylococci and staphylococcal infections. A ten-year study of bacteria and cases of bacteremia. N Engl J Med. 1969 Sep 18;281(12):627–635. [PubMed]
  • Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW. Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection. Ann Intern Med. 1982 Sep;97(3):317–324. [PubMed]
  • Rello J, Torres A, Ricart M, Valles J, Gonzalez J, Artigas A, Rodriguez-Roisin R. Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1545–1549. [PubMed]
  • Holzman RS, Florman AL, Lyman M. Gentamicin resistant and sensitive strains of S. aureus. Factors affecting colonization and virulence for infants in a special care nursery. Am J Epidemiol. 1980 Sep;112(3):352–361. [PubMed]
  • GEZON HM, ROGERS KD, THOMPSON DJ, HATCH TF. Environmental aspects of staphylococcal infections acquired in hospitals. II. Some controversial aspects in the epidemiology of hospital nursery staphylococcal infections. Am J Public Health Nations Health. 1960 Apr;50:473–484. [PubMed]
  • Gezon HM, Schaberg MJ, Klein JO. Concurrent epidemics of Staphlococcus aureus and group A Streptococcus disease in a newborn nursery. Control with penicillin G and hexachlorophene bathing. Pediatrics. 1973 Feb;51(2):383–390. [PubMed]
  • Craven DE, Reed C, Kollisch N, DeMaria A, Lichtenberg D, Shen K, McCabe WR. A large outbreak of infections caused by a strain of Staphylococcus aureus resistant of oxacillin and aminoglycosides. Am J Med. 1981 Jul;71(1):53–58. [PubMed]
  • Huebner J, Pier GB, Maslow JN, Muller E, Shiro H, Parent M, Kropec A, Arbeit RD, Goldmann DA. Endemic nosocomial transmission of Staphylococcus epidermidis bacteremia isolates in a neonatal intensive care unit over 10 years. J Infect Dis. 1994 Mar;169(3):526–531. [PubMed]
  • Donnenberg MS, Kaper JB. Enteropathogenic Escherichia coli. Infect Immun. 1992 Oct;60(10):3953–3961. [PMC free article] [PubMed]
  • Donnenberg MS, Tacket CO, James SP, Losonsky G, Nataro JP, Wasserman SS, Kaper JB, Levine MM. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. J Clin Invest. 1993 Sep;92(3):1412–1417. [PMC free article] [PubMed]
  • Franke J, Franke S, Schmidt H, Schwarzkopf A, Wieler LH, Baljer G, Beutin L, Karch H. Nucleotide sequence analysis of enteropathogenic Escherichia coli (EPEC) adherence factor probe and development of PCR for rapid detection of EPEC harboring virulence plasmids. J Clin Microbiol. 1994 Oct;32(10):2460–2463. [PMC free article] [PubMed]
  • Schmidt H, Plaschke B, Franke S, Rüssmann H, Schwarzkopf A, Heesemann J, Karch H. Differentiation in virulence patterns of Escherichia coli possessing eae genes. Med Microbiol Immunol. 1994 Feb;183(1):23–31. [PubMed]
  • Spitz J, Yuhan R, Koutsouris A, Blatt C, Alverdy J, Hecht G. Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function. Am J Physiol. 1995 Feb;268(2 Pt 1):G374–G379. [PubMed]
  • ROGERS KB, KOEGLER SJ. Inter-hospital cross-infection of epidemic infantile gastro-enteritis associated with type strains of Bacterium coli. J Hyg (Lond) 1951 Jun-Sep;49(2-3):152–161. [PMC free article] [PubMed]
  • Saroglou G, Cromer M, Bisno AL. Methicillin-resistant Staphylococcus aureus: interstate spread of nosocomial infections with emergence of gentamicin-methicillin resistant strains. Infect Control. 1980 Mar-Apr;1(2):81–89. [PubMed]
  • Pavillard R, Harvey K, Douglas D, Hewstone A, Andrew J, Collopy B, Asche V, Carson P, Davidson A, Gilbert G, et al. Epidemic of hospital-acquired infection due to methicillin-resistant Staphylococcus aureus in major Victorian hospitals. Med J Aust. 1982 May 29;1(11):451–454. [PubMed]
  • Lyon BR, Iuorio JL, May JW, Skurray RA. Molecular epidemiology of multiresistant Staphylococcus aureus in Australian hospitals. J Med Microbiol. 1984 Feb;17(1):79–89. [PubMed]
  • Gooch JJ, Britt EM. Staphylococcus aureus colonization and infection in newborn nursery patients. Am J Dis Child. 1978 Sep;132(9):893–896. [PubMed]
  • Saravolatz LD, Markowitz N, Arking L, Pohlod D, Fisher E. Methicillin-resistant Staphylococcus aureus. Epidemiologic observations during a community-acquired outbreak. Ann Intern Med. 1982 Jan;96(1):11–16. [PubMed]
  • Daschner F. Infectious hazards in rooming-in systems. J Perinat Med. 1984;12(1):3–6. [PubMed]

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