1. Faraone SV, Tsuang D, Tsuang MT. Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York, NY: Guildford; 1999.
2. Gottesman, Shields J. Schizophrenia and Genetics; a Twin Study Vantage Point. New York, NY: Academic Press Inc.; 1972.
3. Braff DL, Freedman R. Endophenotypes in studies of the genetics of schizophrenia. In: Davis KL, Charney DS, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology: The fifth generation of progress. Philadelphia, PA: Lippincott Williams and Wilkens; 2002. pp. 703–716.
4. Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry. 2002;7:405–411. [PubMed] 5. Baron M. Genetics of schizophrenia in the new millennium: progress and pitfalls. Am J Hum Genet. 2001;68:299–312. [PubMed] 6. Gottesman, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–645. [PubMed] 7. Gould TD. Gottesman Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav. 2006;5:113–119. [PubMed]
8. Iacono WG. Identifying genetic risk for psychopathology. In: Routh DK, DeRubeis RJ, editors. The Science of Clinical Psychology: Accomplishments and Future Directions. Washington, DC: American Psychological Association; 1998. pp. 3–22.
9. Seidman LJ. Clinical neuroscience and epidemiology in schizophrenia. Harv Rev Psychiatry. 1997;3:338–342. [PubMed] 10. Tsuang MT, Faraone SV, Lyons MJ. Identification of the phenotype in psychiatric genetics. Eur Arch Psychiatry Neurol Sci. 1993;243:131–142. [PubMed] 11. Gur RC, Ragland JD, Moberg PJ, et al. Computerized neurocognitive scanning: II. The profile of schizophrenia. Neuropsychopharmacology. 2001;25:777–788. [PubMed] 12. Gur RC, Ragland JD, Moberg PJ, et al. Computerized neurocognitive scanning: I. Methodology and validation in healthy people. Neuropsychopharmacology. 2001;25:766–788. [PubMed] 13. Adler LE, Freedman R, Ross RG, Olincy A, Waldo MC. Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol Psychiatry. 1999:8–18. [PubMed] 14. Siegel C, Waldo M, Mizner G, Adler L, Freedman R. Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses. Arch Gen Psychiatry. 1984;41:607–612. [PubMed] 15. Adler LE, Pachtman E, Franks RD. Neurophysiological evidence for a deficit in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry. 1982;17:639–654. [PubMed] 16. Braff DL, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 1978;15:339–343. [PubMed] 17. Braff DL, Geyer MA, Light GA, et al. Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophr Res. 2001;49:171–178. [PubMed] 18. Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL. Modulation of the startle response and startle laterality in relatives of schizophrenia patients and schizotypal personality disordered subjects: evidence of inhibitory deficits. Am J Psychiatry. 2000;157:1660–1668. [PubMed] 19. Calkins ME, Curtis CE, Iacono WG, Grove WM. Antisaccade performance is impaired in medically and psychiatrically healthy biological relatives of schizophrenia patients. Schizophr Res. 2004;71:167. [PubMed] 20. Fukushima J, Fukushima K, Chiba T, Tanaka S, Yamashita I, Kato M. Disturbances of voluntary control of saccadic eye movements in schizophrenic patients. Biol Psychiatry. 1988;23:670–677. [PubMed] 21. Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L. The continuous performance test, identical pairs version (CPT-IP) I. New findings about sustained attention in normal families. Psychiatry Res. 1988;26:223–338. [PubMed] 22. Nuechterlein KH, Parasuraman R, Jiang Q. Visual sustained attention: image degradation produces rapid sensitivity decrement over time. Science. 1983;220:327–329. [PubMed] 23. Rosvold HE, Mirsky AF, Sarason I, Bransome ED, Beck LH. A continuous performance test of brain damage. J Consult Psychol. 1956;20:343–350. [PubMed] 24. Cirillo M, Seidman LJ. A review of verbal declarative memory function in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychol Rev. 2003;13:43–77. [PubMed] 25. Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol. 1995;104:286–304. [PubMed] 26. Perry W, Potterat EG, Braff DL. Self-monitoring enhances Wisconsin Card Sorting Test performance in patients with schizophrenia: performance is improved by simply asking patients to verbalize their sorting strategy. J Int Neuropsychol Soc. 2001;7:344–352. [PubMed] 27. Conklin HM, Curtis CE, Calkins ME, Iacono WG. Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiology. Neuropsychologia. 2005;43:930–942. [PubMed] 28. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry. 1997;54:159–166. [PubMed] 29. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 1992;49:975–982. [PubMed]
30. Greenwood TA, Braff DL, Cadenhead KS, et al. 2006. The Consortium on the Genetics of Schizophrenia (COGS): preliminary heritability analyses of endophenotypic measures for schizophrenia.
31. Horan WP, Braff DL, Nuechterlein KH, et al. 2006. Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia.
32. Radant A, Dobie DJ, Calkins ME, et al. Schizophr Res. Successful multi-site measurement of antisaccade performance deficits in schizophrenia.
33. Schork NJ, et al. Schizophr Bull. 2007.
34. Carey G, Williamson J. Linkage analysis of quantitative traits: increased power by using selected samples. Am J Hum Genet. 1991;49:786–796. [PubMed] 35. Gu C, Todorov AA, Rao DC. Genome screening using extremely discordant and extremely concordant sib pairs. Genet Epidemiol. 1997;14:791–796. [PubMed] 36. Risch N, Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science. 1995;268:158–159. [PubMed] 37. Risch N, Zhang H. Mapping quantitative traits loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet. 1996;58:836–843. [PubMed]
38. Ott J. Analysis of Human Genetic Linkage. Baltimore, MD: Johns Hopkins University Press; 1999.
39. Nurnberger JI, Jr, Blehar MC, Kaufmann CA, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry. 1994;51:849–859. [PubMed] 40. Hall RC, Parks J. The modified global assessment of functioning scale: addendum. Psychosomatics. 1995;36:416–417. [PubMed]
41. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS) Iowa City, Iowa: The University of Iowa; 1984.
42. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS) Iowa City, Iowa: The University of Iowa; 1983.
43. Kendler KS, Lieberman JA, Walsh D. The structured interview for schizotypy (SIS): a preliminary report. Schizophr Bull. 1989;15:559–571. [PubMed]
44. Maxwell ME. FIGS: Clinical Neurogenetics Branch, Intramural Research Program. Betesia, MD: NIMH; 1996.
45. Ventura J, Lukoff D, Nuechterlein KH, Liberman RP, Green MF, Shaner A. Appendix 1: Brief Psychiatric Rating Scale (BPRS) expanded version (4): scales, anchor points, and administration manual. Int J Methods Psychiatr Res. 1993;3:227–244.
46. Griffith J, Hoffer LD, Adler LE, Zerbe GO, Freedman R. Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Psychophysiology. 1995;32:460–466. [PubMed]
47. Nuechterlein KH, Asarnow RF. Degraded Stimulus Continuous Performance Test (DS-CPT) Program for IBM-Compatible Microcomputers, Version 8.12. Los Angeles, CA: Nuechterlein and Asarnow; 1999.
48. Nuechterlein KH. Vigilance in schizophrenia and related disorders. In: Steinhauer SR, Gruzelier JH, Zubin J, editors. Handbook of Schizophrenia, Vol. 5: Neuropsychology, Psychophysiology, and Information processing. Amsterdam, Netherlands: Elsevier; 1991. pp. 397–433.
49. Wechsler D. Wechsler Adult Intelligence Scale. San Antonio, TX: Psychological Corporation; 1997.
50. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test-Adult version. New York, NY: The Psychological Corporation; 1987.
51. Delis D, Kramer J, Kaplan E, Ober B. California Verbal Learning Test: Second Edition. Adult version. Manual. New York, NY: The Psychological Corporation; 2000.
52. Calkins ME, Gur RC, Ragland JD, Gur RE. Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives. Am J Psychiatry. 2005;162:1963–1966. [PubMed]
53. Gur RE, Nimgaonkar VL, Almasy L, et al. 2006. Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. under review.
54. Aliyu MH, Calkins ME, Swanson CL, et al. Project among African Americans to explore risks for schizophrenia: assessment and recruitment methods. Schizophr Res. In press.
55. Kurtz M, Ragland J, Moberg P, Gur R. The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms for repeat administration. Arch Clin Neuropsychol. 2004;19:191–201. [PubMed] 56. Ragland JD, Turetsky BI, Gur RC, et al. Working memory for complex figures: an fMRI comparison of letter and fractal N-back tasks. Neuropsychology. 2002;16:370–379. [PubMed] 57. Gur RC, Jaggi JL, Ragland JD, et al. Effects of memory processing on regional brain activation: cerebral blood flow in normal subjects. Int J Neurosci. 1993;72:31–44. [PubMed] 58. Glahn DC, Gur RC, Ragland JD, Gur RE. Reliability, performance characteristics, and construct validity and initial application of the visual object learning test (VOLT) Neuropsychology. 1997;11:602–612. [PubMed] 59. Kohler CG, Turner TH, Bilker WB, et al. Facial emotion recognition in schizophrenia: intensity effects and error pattern. Am J Psychiatry. 2003;160:1768–1774. [PubMed] 60. Isohanni I, Jones PB, Jarvelin MR, et al. Educational consequences of mental disorders treated in hospital. A 31-year follow-up of the Northern Finland 1966 birth cohort. Psychol Med. 2001;31:339–349. [PubMed] 61. Shriver MD, Kennedy GC, Parra EJ, et al. The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs. Hum Genomics. 2004;1:274–286. [PMC free article] [PubMed] 62. Reiner AP, Ziv E, Lind DL, et al. Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet. 2005;76:463–477. [PubMed] 63. Abecasis GR, Cookson WO, Cardon LR. The power to detect linkage disequilibrium with quantitative traits in selected samples. Am J Hum Genet. 2001;68:1463–1474. [PubMed] 64. deAndrade M, Amos CI. Ascertainment issues in variance component models. Genet Epidemiol. 2000;19:333–344. [PubMed] 65. Iyengar S, Calafell F, Kidd KK. Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes. Genet Epidemiol. 1997;14:809–814. [PubMed] 66. Todorov AA, Province MA, Borecki IB, Rao DC. Trade-off between sibship size and sampling scheme for detecting quantitative trait loci. Hum Hered. 1997;47:1–5. [PubMed] 67. Lander ES, Schork NJ. The genetic dissection of complex traits. Science. 1994;265:2037–2048. [PubMed]
68. Kendler KS. The super-normal control group in psychiatric genetics: possible artifactual evidence for coaggregation. Psychiatr Genet. 1990:45–53.