1. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005;10:40–68. [PubMed] 2. Owen MJ, Craddock N, O'Donovan MC. Schizophrenia: genes at last? Trends Genet. 2005;21:518–525. [PubMed]
3. Bleuler E. Dementia Praecox or the Group of Schizophrenias. New York, NY: International Universities Press; 1950.
4. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophr Bull. 2000;26:119–136. [PubMed] 5. Calkins ME, Dorcas DJ, Cadenhead KS, et al. Schizophr Bull. The Consortium on the Genetics of Endophenotypes in Schizophrenia (COGS): “model” recruitment, assessment, and endophenotyping methods for a multi-site collaboration. [PMC free article] [PubMed] 6. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–645. [PubMed] 7. Aleman A, Hijman R, de Haan EHF, Kahn RS. Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry. 1999;156:1358–1366. [PubMed] 8. Snitz BE, Macdonald AW, III, Carter CS. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull. 2006;32:179–194. [PMC free article] [PubMed]
9. Kraepelin E. Dementia Praecox and Paraphrenia. Edinburgh, Scotland: E. & S. Livingston; 1919.
10. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Bull. 1993;19:233–259. [PubMed] 11. Nuechterlein KH. Reaction time and attention in schizophrenia: a critical evaluation of the data and theories. Schizophr Bull. 1977;3:373–428. [PubMed] 12. Nuechterlein KH, Dawson ME. Information processing and attentional functioning in the developmental course of schizophrenia disorders. Schizophr Bull. 1984;10:160–203. [PubMed] 13. Shakow D. Segmental set: a theory of the formal psychological deficit in schizophrenia. Arch Gen Psychiatry. 1962;6:1–17. [PubMed] 14. Seidman LJ. Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychol Bull. 1983;94:195–238. [PubMed] 15. Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull. 1994;20:31–46. [PubMed]
16. Nuechterlein KH. Vigilance in schizophrenia and related disorders. In: Steinhauer SR, Gruzelier JH, Zubin J, editors. Handbook of Schizophrenia, Neuropsychology, Psychophysiology and Information Processing. Amsterdam, The Netherlands: Elsevier Science Publishers; 1991. pp. 397–433.
17. Nestor PG, Han SD, Niznikiewicz M, et al. Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention. Biol Psychol. 2001;57:23–46. [PMC free article] [PubMed] 18. Cohen JD, Braver TS, O'Reilly RC. A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges. Philos Trans R Soc Lond B Biol Sci. 1996;351:1515–1527. [PubMed] 19. Cohen JD, Barch DM, Carter C, Servan-Schreiber D. Context-processing deficits in schizophrenia: Converging evidence from three theoretically motivated cognitive tasks. J Abnorm Psychol. 1999;108:120–133. [PubMed] 20. Nuechterlein KH, Barch DM, Gold JM, et al. Identification of separable cognitive factors in schizophrenia. Schizophr Res. 2004;72:29–39. [PubMed] 21. Chen WJ, Faraone SV. Sustained attention deficits as markers of genetic susceptibility to schizophrenia. Am J Med Genet. 2000;97:52–57. [PubMed] 22. Cornblatt BA, Malhotra AK. Impaired attention as an endophenotype for molecular genetic studies of schizophrenia. Am J Med Genet. 2001;105:11–15. [PubMed]
23. Nuechterlein KH, Asarnow RF, Subotnik KL, et al. Neurocognitive vulnerability factors for schizophrenia: convergence across genetic risk studies and longitudinal trait/state studies. In: Dworkin R, editor. Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. Washington, DC: American Psychological Association; 1998. pp. 299–327.
24. Rosvold HE, Mirsky AF, Sarason I, Bransome ED, Jr, Beck LH. A continuous performance test of brain damage. J Consult Psychol. 1956;20:343–350. [PubMed] 25. Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L. The Continuous Performance Test, Identical Pairs Version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res. 1988;26:223–238. [PubMed] 26. Nuechterlein KH. Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. J Abnorm Psychol. 1983;92:4–28. [PubMed] 27. Riccio CA, Reynolds CR, Lowe P, Moore JJ. The continuous performance test: a window on the neural substrates for attention? Arch Clin Neuropsychol. 2002;17:235–272. [PubMed] 28. Mirsky AF, Anthony BJ, Duncan CC, Ahearn MB, Kellam SG. Analysis of the elements of attention: a neuropsychological approach. Neuropsychol Rev. 1991;2:109–145. [PubMed] 29. Seidman LJ, Breiter HC, Goodman JM, et al. A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands. Neuropsychology. 1998;12:505–518. [PubMed]
30. Green DM, Swets JA. Signal Detection Theory and Psychophysics. New York, NY: Wiley; 1966.
31. Nuechterlein KH, Parasuraman R, Jiang Q. Visual sustained attention: image degradation produces rapid sensitivity decrement over time. Science. 1983;220:327–329. [PubMed] 32. Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L. The continuous performance test, identical pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients. Psychiatry Res. 1989;29:65–85. [PubMed] 33. Heinrichs RW, Zakzanis KK. Neurocognitive deficits in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445. [PubMed] 34. Ito M, Kanno M, Mori Y, Niwa S. Attention deficits assessed by Continuous Performance Test and Span of Apprehension Test in Japanese schizophrenic patients. Schizophr Res. 1997;23:205–211. [PubMed] 35. Bowen L, Wallace CJ, Glynn SM, et al. Schizophrenic individuals' cognitive functioning and performance in interpersonal interactions and skills training procedures. J Psychiatr Res. 1994;28:289–301. [PubMed] 36. Orzack MH, Kornetsky C. Attention dysfunction in chronic schizophrenia. Arch Gen Psychiatry. 1966;14:323–326. [PubMed] 37. Seidman LJ, Van Manen KJ, Turner WM, et al. The effects of increasing resource demand on vigilance performance in adults with schizophrenia or developmental attentional/learning disorders: a preliminary study. Schizophr Res. 1998;34:101–112. [PubMed] 38. Walker E. Attentional and neuromotor functions of schizophrenics, schizoaffectives, and patients with other affective disorders. Arch Gen Psychiatry. 1981;38:1355–1358. [PubMed] 39. Nuechterlein KH, Dawson ME, Gitlin M, et al. Developmental processes in schizophrenic disorders: longitudinal studies of vulnerability and stress. Schizophr Bull. 1992;18:387–425. [PubMed] 40. Egan MF, Goldberg TE, Gscheidle T, et al. Relative risk of attention deficits in siblings of patients with schizophrenia. Am J Psychiatry. 2000;157:1309–1316. [PubMed]
41. Braff DL, Freedman R. The importance of endophenotypes in studies of the genetics of schizophrenia. In: Davis K, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology: The Fifth Generation of Progress: An Official Publication of the American College of Neuropsychopharmacology. Philadelphia, Pa: Lippincott/Williams & Wilkins; 2002. pp. 703–716.
42. Rutschmann J, Cornblatt B, Erlenmeyer-Kimling L. Sustained attention in children at risk for schizophrenia. Arch Gen Psychiatry. 1977;34:571–575. [PubMed] 43. Cornblatt B, Obuchowski M, Roberts S, Pollack S, Erlenmeyer-Kimling L. Cognitive and behavioral precursors of schizophrenia. Dev Psychopathol. 1999;11:487–508. [PubMed] 44. Maier W, Franke P, Hain C, Kopp B, Rist F. Neuropsychological indicators of the vulnerability to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1992;16:703–715. [PubMed] 45. Chen WJ, Liu SK, Chang CJ, et al. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry. 1998;155:1214–1220. [PubMed] 46. Grove WM, Lebow BS, Clementz BA, et al. Familial prevalence and coaggregation of schizotypy indicators: a multitrait family study. J Abnorm Psychol. 1991;100:115–121. [PubMed] 47. Chen WJ, Chang CH, Liu SK, Hwang TJ, Hwu HG. Sustained attention deficits in nonpsychotic relatives of schizophrenic patients: a recurrence risk ratio analysis. Biol Psychiatry. 2004;55:995–1000. [PubMed] 48. Asarnow RF, Nuechterlein KH, Subotnik KL, et al. Neurocognitive impairments in non-psychotic parents of children with schizophrenia and attention deficit hyperactivity disorder: the UCLA Family Study. Arch Gen Psychiatry. 2002;59:1053–1060. [PubMed] 49. Saoud M, d'Amato T, Gutknecht C, et al. Neuropsychological deficit in siblings discordant for schizophrenia. Schizophr Bull. 2000;26:893–902. [PubMed] 50. Franke P, Maier W, Hardt J, Hain C, Cornblatt BA. Attentional abilities and measures of schizotypy: their variation and covariation in schizophrenic patients, their siblings, and normal control subjects. Psychiatry Res. 1994;54:259–272. [PubMed] 51. Finkelstein JRJ, Cannon TD, Gur RE, Gur RC, Moberg P. Attentional dysfunctions in neuroleptic-naive and neuroleptic-withdrawn schizophrenic patients and their siblings. J Abnorm Psychol. 1997;106:203–212. [PubMed] 52. Mirsky AF, Lochhead SJ, Jones BP, et al. On familial factors in the attentional deficit in schizophrenia: a review and report of two new subject samples. J Psychiatr Res. 1992;26:383–403. [PubMed] 53. Laurent A, Saoud M, Bougerol T, et al. Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives. Psychiatry Res. 1999;89:147–159. [PubMed] 54. Appels MC, Sitskoorn MM, Westers P, Lems E, Kahn RS. Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patients. Schizophr Res. 2003;63:285–293. [PubMed] 55. Cirillo M, Seidman LJ. A review of verbal declarative memory function in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychol Rev. 2003;13:43–77. [PubMed] 56. Gold JM. Cognitive deficits as treatment targets in schizophrenia. Schizophr Res. 2004;72:21–28. [PubMed] 57. Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC, Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res. 2004;71:285–295. [PubMed] 58. Trandafir A, Méarya A, Schürhoffa F, Leboyera M, Szöke A. Memory tests in first-degree adult relatives of schizophrenic patients: a meta-analysis. Schizophr Res. 2006;81:217–226. [PMC free article] [PubMed] 59. Lee J, Park S. Working memory impairments in schizophrenia: a meta-analysis. J Abnorm Psychol. 2005;114:599–611. [PubMed] 60. Erlenmeyer-Kimling L, Rock D, Roberts SA, et al. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York high-risk project. Am J Psychiatry. 2000;157:1416–1422. [PubMed] 61. Jones LA, Cardno AG, Sanders RD, Owen MJ, Williams J. Sustained and selective attention as measures of genetic liability to schizophrenia. Schizophr Res. 2001;48:263–272. [PubMed]
62. Nuechterlein KH, Dawson ME, Ventura J, Yee-Bradbury C. Longitudinal stability of vigilance and span of apprehension deficits in the early phase of schizophrenia. Sixth Annual Meeting of the Society for Research in Psychopathology; 1991; Cambridge, MA.
63. Nuechterlein KH, Asarnow RF. Degraded Stimulus Continuous Performance Test (DS-CPT) Program for IBM-Compatible Microcomputers, Version 8.12. Los Angeles, CA: Nuechterlein KH and Asarnow RF; 1999.
64. Nuechterlein KH, Green MF, Subotnik KL, et al. Cognitive factors are highly predictive of work outcome in the early course of schizophrenia. Mt. Sinai Conference on Cognition in Schizophrenia; 1999; Santa Fe, NM.
65. Suslow T, Arolt V. Paranoid schizophrenia: non-specificity of neuropsychological vulnerability markers. Psychiatry Res. 1997;72:103–114. [PubMed] 66. Wohlberg GW, Kornetsky C. Sustained attention in remitted schizophrenics. Arch Gen Psychiatry. 1973;28:533–537. [PubMed] 67. Orzack MH, Kornetsky C, Freeman H. The effects of daily administration of carphenazine on attention in the schizophrenic patient. Psychopharmacologia. 1967;11:31–38. [PubMed] 68. Spohn HE, Lacoursiere RB, Thompson K, Coyne L. Phenothiazine effects on psychological and psychophysiological dysfunction in chronic schizophrenics. Arch Gen Psychiatry. 1977;34:633–644. [PubMed] 69. Sax KW, Strakowski SM, Keck PE., Jr Attentional improvement following quetiapine fumarate treatment in schizophrenia. Schizophr Res. 1998;33:151–155. [PubMed] 70. Keefe RS, Seidman LJ, Christensen BK, et al. Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis. Biol Psychiatry. 2006;59:97–105. [PubMed] 71. Liu SK, Chen WJ, Chang CJ, Lin HN. Effects of atypical neuroleptics on sustained attention deficits in schizophrenia: a trial of risperidone versus haloperidol. Neuropsychopharmacology. 2000;22:311–319. [PubMed] 72. Asarnow RF, MacCrimmon DJ. Residual performance deficit in clinically remitted schizophrenics: a marker of schizophrenia? J Abnorm Psychol. 1978;87:597–608. [PubMed] 73. Nuechterlein KH, Asarnow RF, Subotnik KL, et al. The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study. Schizophr Res. 2002;54:121–130. [PubMed] 74. Cornblatt B, Lenzenweger MF, Dworkin R, Erlenmeyer-Kimling L. Childhood attentional dysfunction predicts social deficits in unaffected adults at risk for schizophrenia. Br J Psychiatry. 1992;161:59–64. [PubMed] 75. Laurent A, Biloa-Tang M, Bougerol T, et al. Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. Schizophr Res. 2000;46:269–283. [PubMed] 76. Buchsbaum MS, Nuechterlein KH, Haier RJ, et al. Glucose metabolic rate in normals and schizophrenics during the Continuous Performance Test assessed by positron emission tomography. Br J Psychiatry. 1990;156:216–227. [PubMed] 77. Siegel BV, Nuechterlein KH, Abel L, Wu JC, Buchsbaum MS. Glucose metabolic correlates of continuous performance test performance in adults with a history of infantile autism, schizophrenics, and controls. Schizophr Res. 1995;17:85–94. [PubMed] 78. Siegel BV, Jr, Buchsbaum MS, Bunney WE,, Jr, et al. Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. Am J Psychiatry. 1993;150:1325–1336. [PubMed] 79. Thermenos HW, Seidman LJ, Breiter H, et al. Functional MRI during auditory verbal working memory in non-psychotic relatives of persons with schizophrenia: a pilot study. Biol Psychiatry. 2004;55:490–500. [PubMed] 80. Sponheim SR, McGuire KA, Stanwyck JJ. Neural anomalies during sustained attention in first-degree biological relatives of schizophrenia patients. Biol Psychiatry. 2006;60:642–652. [PubMed] 81. Faraone SV, Seidman LJ, Kremen WS, et al. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol. 1995;104:286–304. [PubMed] 82. van Amelsvoort T, Henry J, Morris R, et al. Cognitive deficits associated with schizophrenia in velo-cardio-facial syndrome. Schizophr Res. 2004;70:223–232. [PubMed] 83. Hallmayer JF, Kalaydjieva L, Badcock J, et al. Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit. Am J Hum Genet. 2005;77:468–476. [PubMed] 84. Greenwood PM, Parasuraman R. Normal genetic variation, cognition, and aging. Behav Cogn Neurosci Rev. 2003;2:278–306. [PMC free article] [PubMed] 85. Freedman R, Coon H, Myles-Worsley M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA. 1997;94:587–592. [PubMed] 86. Cullum CM, Harris JG, Waldo MC, et al. Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia. Schizophr Res. 1993;10:131–141. [PubMed] 87. Saykin AJ, Gur RC, Gur RE, et al. Neuropsychological function in schizophrenia. Selective impairment in memory and learning. Arch Gen Psychiatry. 1991;48:618–624. [PubMed] 88. Siever L, Davis K. The pathophysiology of schizophrenia disorders: perspectives from the spectrum. Am J Psychiatry. 2004;161:398–413. [PubMed]
89. Kremen WS, Hoff AL. Neurocognitive deficits in the biological relatives of individuals with schizophrenia. In: Stone W, Faraone S, Tsuang M, editors. Early Clinical Intervention and Prevention with Schizophrenia. Totowa, NJ: Humana Press; 2004. pp. 133–158.
90. Beatty WW, Jocic Z, Monson N, Staton D. Memory and frontal lobe dysfunction in schizophrenia and schizoaffective disorder. J Nerv Ment Dis. 1993;181:448–453. [PubMed] 91. Gold J, Randolph C, Carpenter C, Goldberg T, Weinberger D. Forms of memory failure in schizophrenia. J Abnorm Psychol. 1992;101:487–494. [PubMed]
92. Seidman L, Cassens G, Kremen W, Pepple J. Neuropsychology of schizophrenia. In: White R, editor. Clinical Syndromes in Adult Neuropsychology: The Practitioner's Handbook. Amsterdam, The Netherlands: Elsevier Science Publishers; 1992. pp. 381–449.
93. Paulsen JS, Heaton RK, Sadek JR, et al. The nature of learning and memory impairments in schizophrenia. J Int Neuropsychol Soc. 1995;1:88–99. [PubMed] 94. Gold J, Blaxton T, Hermann B, et al. Memory and intelligence in lateralized temporal lobe epilepsy and schizophrenia. Schizophr Res. 1995:59–65. [PubMed] 95. Seidman LJ, Stone WS, Jones R, Harrison RH, Mirsky AF. Effects of schizophrenia and complex partial epilepsy on memory. J Int Neuropsychol Soc. 1998;4:342–352. [PubMed] 96. Heaton R, Paulsen J, LA M, et al. Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia. Arch Gen Psychiatry. 1994;51:469–476. [PubMed] 97. Brebion G, Amador X, Smith MJ, Gorman JM. Mechanisms underlying memory impairment in schizophrenia. Psychol Med. 1997;27:383–393. [PubMed] 98. Weiss A, Heckers S. Neuroimaging of declarative memory in schizophrenia. Scand J Psychol. 2001;42:239–250. [PubMed]
99. Wechsler D. Wechsler Memory Scale—Third Edition. San Antonio, Tex: The Psychological Corporation, Harcourt Brace & Company; 1997.
100. Delis D, Kramer J, Kaplan E, Ober B. California Verbal Learning Test: Second Edition. Adult Version. Manual. New York, NY: The Psychological Corporation; 2000.
101. Harvey PD, Palmer BW, Heaton RK, et al. Stability of cognitive performance in older patients with schizophrenia: an 8-week test-retest study. Am J Psychiatry. 2005;162:110–117. [PubMed] 102. Ferris SH, Mackell JA, Mohs R, et al. A multicenter evaluation of new treatment efficacy instruments for Alzheimer's disease clinical trials: overview and general results: the Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997;11(suppl 2):S1–S12. [PubMed] 103. Faraone SV, Seidman LJ, Kremen WS, et al. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J Abnorm Psychol. 1999;108:176–181. [PubMed] 104. Brebion G, Bressan RA, Amador X, Malaspina D, Gorman JM. Medications and verbal memory impairment in schizophrenia: the role of antipsychotic drugs. Psychol Med. 2004;34:369–374. [PubMed] 105. Joyce E. Origins of cognitive dysfunction in schizophrenia: clues from age at onset. Br J Psychiatry. 2005;186:93–95. [PubMed] 106. Saykin AJ, Shtasel DL, Gur RE, et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch Gen Psychiatry. 1994;51:124–131. [PubMed] 107. Thornton AE, Van Snellenberg JX, Sepehry AA, Honer W. The impact of antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: a quantitative review. J Psychopharmacol. 2006;20:335–346. [PubMed] 108. Heinrichs R. The primacy of cognition in schizophrenia. Am Psychol. 2005;60:229–242. [PubMed] 109. Cannon TD, Zorrilla LE, Shtasel DL, et al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry. 1994;51:651–661. [PubMed] 110. Faraone SV, Seidman LF, Kremen WS, et al. Neuropsychological functioning among the nonpsychotic relatives of schizophrenia patients: the effect of genetic loading. Biol Psychiatry. 2000;48:120–126. [PubMed] 111. Seidman LJ, Giuliano AJ, Smith CW. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside adolescent high risk studies. Schizophr Bull. 2006;20:507–524. [PMC free article] [PubMed] 112. Bouchard T., Jr Genetic and environmental influences on adult intelligence and special mental abilities. Hum Biol. 1988;70:257–279. [PubMed] 113. Finkel D, Pedersen NL, McGue M, McClearn GE. Heritability of cognitive abilities in adult twins: comparison of Minnesota and Swedish data. Behav Genet. 1995;25:421–431. [PubMed] 114. Lee JH, Flaquer A, Stern Y, Tycko B, Mayeux R. Genetic influences on memory performance in familial Alzheimer disease. Neurology. 2004;62:414–421. [PubMed] 115. Weickert TW, Goldberg TE, Gold JM, et al. Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry. 2000;57:907–913. [PubMed] 116. Tuulio-Henriksson A, Haukka J, Partonen T, et al. Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia. Am J Med Genet. 2002;114:483–490. [PubMed] 117. Johnson JK, Tuulio-Henriksson A, Pirkolac T, et al. Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients? Biol Psychiatry. 2003;54:1200–1204. [PubMed] 118. Cannon TD, Huttunen MO, Lonnqvist J, et al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet. 2000;67:369–382. [PubMed]
119. Broadbent NJ, Clark RE, Zola S, Squire LR. The medial temporal lobe and memory. In: Squire LR, Schacter DL, editors. Neuropsychology of Memory. New York, NY: The Guilford Press; 2002. pp. 3–23.
120. Harrison PJ. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology. 2004;174:151–162. [PubMed]
121. Wagner AD. Cognitive control and episodic memory: contributions from prefrontal cortex. In: Squire LR, Schacter DL, editors. Neuropsychology of Memory. New York, NY: The Guilford Press; 2002. pp. 174–192.
122. Weinberger DR. Cell biology of the hippocampal formation in schizophrenia. Biol Psychiatry. 1999;45:395–402. [PubMed] 123. Seidman LJ, Faraone SV, Goldstein JM, et al. Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Arch Gen Psychiatry. 2002;59:839–849. [PubMed] 124. Cannon TD, Hennah W, van Erp TG, et al. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry. 2005;62:1205–1213. [PubMed] 125. Paunio T, Tuulio-Henriksson A, Hiekkalinna T, et al. Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q. Hum Mol Genet. 2004;13:1693–1702. [PubMed]
126. Goldman-Rakic PS. Working memory dysfunction in schizophrenia. In: Salloway SP, Malloy PF, Duffy JD, editors. The Frontal Lobes and Neuropsychiatric Illness. Washington, DC: American Psychiatric Publishing, Inc.; 2001. pp. 71–82.
127. Miyake A, Shah P. Models of Working Memory: Mechanisms of Active Maintenance and Executive Control. New York, NY: Cambridge University Press; 1999.
128. Repovs G, Bresjanac M. Cognitive neuroscience of working memory: a prologue [Introduction to special issue on working memory] Neuroscience. 2006;139:1–3.
129. Baddeley AD. Working Memory. New York, NY: Oxford University Press; 1986.
130. Baddeley AD. The episodic buffer: a new component of working memory? Trends Cogn Sci. 2000;4:417–423. [PubMed]
131. Petrides M. Mapping prefrontal cortical systems for the control of cognition. In: Toga AW, Mazziotta JC, editors. Brain Mapping: The Systems. San Diego, Calif: Academic Press; 2000. pp. 159–176.
132. Goldman-Rakic PS. The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive. In: Roberts AC, Robbins TW, Weiskrantz L, editors. The Prefrontal Cortex: Executive and Cognitive Functions. Oxford University Press; 1998. pp. 87–102. [PubMed] 133. Collette F, van der Linden M. Brain imaging of the central executive component of working memory. Neurosci Biobehav Rev. 2002;26:105–125. [PubMed] 134. Constantinidis C, Procyk E. The primate working memory networks. Cogn Affect Behav Neurosci. 2004;4:444–465. [PMC free article] [PubMed]
135. D'Esposito M, Postle BR. The Organization of Working Memory Function in Lateral Prefrontal Cortex: Evidence from Event-related Functional MRI. New York, NY: Oxford University Press; 2002.
136. Sawaguchi T, Goldman-Rakic PS. D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science. 1991;251:947–950. [PubMed] 137. Smith EE, Jonides J. Storage and executive processes in the frontal lobes. Science. 1999;283:1657–1661. [PubMed] 138. Perry W, Heaton RK, Potterat E, et al. Working memory in schizophrenia: transient “online” storage versus executive functioning. Schizophr Bull. 2001;27:157–176. [PubMed] 139. Castner SA, Goldman-Rakic PS, Williams GV. Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia. Psychopharmacology. 2004;174:111–125. [PubMed] 140. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry. 1997;54:159–165. [PubMed] 141. Barch DM. The cognitive neuroscience of schizophrenia. Annu Rev Clin Psychol. 2005;1:321–353. [PubMed] 142. Kim J, Glahn DC, Nuechterlein KH, Cannon TD. Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophr Res. 2004;68:173–187. [PubMed] 143. Conklin HM, Curtis CE, Calkins ME, Iacono WG. Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiology. Neuropsychologia. 2005;43:930–942. [PubMed] 144. Hutton SB, Puri BK, Duncan LJ, et al. Executive function in first-episode schizophrenia. Psychol Med. 1998;28:463–473. [PubMed] 145. Kopelowicz A, Liberman RP, Ventura J, Zarate R. Mintz J. Neurocognitive correlates of recovery from schizophrenia. Psychol Med. 2005;35:1165–1173. [PubMed] 146. Smith TE, Hull JW, Huppert JD. Silverstein SM. Recovery from psychosis in schizophrenia and schizoaffective disorder: symptoms and neurocognitive rate-limiters for the development of social behavior skills. Schizophr Res. 2002;55:229–237. [PubMed] 147. Heaton RK, Gladsjo JA, Palmer BW, et al. Stability and course of neuropsychological deficits in schizophrenia. Arch Gen Psychiatry. 2001;58:24–32. [PubMed] 148. Hill SK, Schuepbach D, Herbener ES, Keshavan MS, Sweeney JA. Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia. Schizophr Res. 2004;68:49–63. [PubMed] 149. Park S, Püschel J, Sauter BH, Rentsch M, Hell D. Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study. Biol Psychiatry. 1999;46:392–400. [PubMed] 150. Park S, Püschel J, Sauter BH, Rentsch M, Hell D. Spatial selective attention and inhibition in schizophrenia patients during acute psychosis and at 4-month follow-up. Biol Psychiatry. 2002;51:498–506. [PubMed] 151. Tyson PJ, Laws KR, Roberts KH, Mortimer AM. A longitudinal analysis of memory in patients with schizophrenia. J Clin Exp Neuropsychol. 2005;27:718–734. [PubMed] 152. Daban C, Amado I, Baylé F, et al. Disorganization syndrome is correlated to working memory deficits in unmedicated schizophrenic patients with recent onset schizophrenia. Schizophr Res. 2003;61:323–324. [PubMed] 153. Pantelis C, Harvey CA, Plant G, et al. Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability. Psychol Med. 2004;34:693–703. [PubMed] 154. Silver H, Feldman P, Bilker W, Gur RC. Working memory deficit as a core neuropsychological dysfunction in schizophrenia. Am J Psychiatry. 2003;160:1809–1816. [PubMed] 155. Barch DM, Carter CS, Braver TS, et al. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry. 2001;58:280–288. [PubMed] 156. Carter C, Robertson L, Nordahl T, Chaderjian M. Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients. Biol Psychiatry. 1996;40:930–932. [PubMed] 157. Green MF, Marshall BD,, Jr, Wirshing WC, et al. Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am J Psychiatry. 1997;154:799–804. [PubMed] 158. Lussier I, Stip E. Memory and attention deficits in drug naive patients with schizophrenia. Schizophr Res. 2001;48:45–55. [PubMed] 159. Ando J, Ono Y, Wright MJ. Genetic structure of spatial and verbal working memory. Behav Genet. 2001;31:615–624. [PubMed] 160. Hansell NK, Wright MJ, Luciano M, et al. Genetic covariation between event-related potential (ERP) and behavioral non-ERP measures of working-memory, processing speed, and IQ. Behav Genet. 2005;35:695–706. [PubMed] 161. Tuulio-Henriksson A, Arajarvi R, Partonen T, et al. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients. Biol Psychiatry. 2003;54:623–628. [PubMed] 162. Glahn DC, Therman S, Manninen M, et al. Spatial working memory as an endophenotype for schizophrenia. Biol Psychiatry. 2003;53:624–626. [PubMed] 163. Wager TD, Smith EE. Neuroimaging studies of working memory: a meta-analysis. Cogn Affect Behav Neurosci. 2003;3:255–274. [PubMed] 164. Braver TS, Barch DM. A theory of cognitive control, aging cognition, and neuromodulation. Neurosci Biobehav Rev. 2002;26:809–817. [PubMed]
165. Jonides J, Lacey SC, Nee DE. Processes of working memory in mind and brain. Curr Dir Psychol Sci. 2005;14:2–5.
166. Owen AM, McMillan KM, Laird AR, Bullmore E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp. 2005;25:46–59. [PubMed]
167. Bunney BG, Bunney WE, Stein R, Potkin SG. Cortical pathology in schizophrenia: a review of data from the dorsolateral prefrontal cortex. Curr Opin Psychiatry. 2003;16:S9–S14.
168. Davidson LL, Heinrichs RW. Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis. Psychiatry Res Neuroimaging. 2003;122:69–87. [PubMed]
169. Grace AA. Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia. In: Keshavan MS, Kennedy JL, Murray RM, editors. Neurodevelopment and Schizophrenia. New York, NY: Cambridge University Press; 2004. pp. 273–294.
170. Selemon LD, Kleinman JE, Herman MM, Goldman-Rakic PS. Smaller frontal gray matter volume in postmortem schizophrenic brains. Am J Psychiatry. 2002;59:1983–1991. [PubMed] 171. Selemon LD, Mrzljak J, Kleinman JE, Herman MM, Goldman-Rakic PS. Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9. Arch Gen Psychiatry. 2003;60:69–77. [PubMed] 172. Steen RG, Hamer RM, Lieberman JA. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology. 2005;30:1949–1962. [PubMed] 173. Callicott JH, Bertolino A, Mattay VS, et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex. 2000;10:1078–1092. [PubMed] 174. Callicott JH, Egan MF, Mattay VS, et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry. 2003;160:709–719. [PubMed] 175. Cannon TD, Glahn DC, Kim J, et al. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005;62:1071–1080. [PubMed] 176. Carter CS, Perlstein W, Ganguli R, et al. Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry. 1998;155:1285–1287. [PubMed] 177. Glahn DC, Ragland JD, Abramoff A, et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp. 2005;25:60–69. [PubMed] 178. Bruder GE, Keilp JG, Xu H, et al. Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry. 2005;58:901–907. [PubMed] 179. Goldberg TE, Weinberger DR. Genes and the parsing of cognitive processes. Trends Cogn Sci. 2004;8:325–335. [PubMed] 180. Ho BC, Wassink TH, O'Leary DS, Sheffield VC, Andreasen NC. Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow. Mol Psychiatry. 2005;10:229, 287–298. [PubMed] 181. Stefanis NC, van Os J, Avramopoulos D, et al. Variation in catechol-O-methyltransferase val158met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biol Psychiatry. 2004;56:510–515. [PubMed] 182. Burdick KE, Hodgkinson CA, Szeszko PR, et al. DISC1 and neurocognitive function in schizophrenia. Neuroreport. 2005;16:1399–1402. [PubMed] 183. Gasperoni TL, Ekelund J, Huttunen M, et al. Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. Am J Hum Genet. 2003;116B:8–16. [PubMed] 184. Parasuraman R, Greenwood PM, Kumar R, Fossella J. Beyond heritability: neurotransmitter genes differentially modulate visuospatial attention and working memory. Psychol Science. 2005;16:200–207. [PMC free article] [PubMed] 185. Keefe RSE, Seidman LJ, Christensen BK, et al. Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol. Am J Psychiatry. 2004;161:985–995. [PubMed] 186. McGurk SR, Carter C, Goldman R, et al. The effects of clozapine and risperidone on spatial working memory in schizophrenia. Am J Psychiatry. 2005;162:1013–1016. [PubMed] 187. Gur RC, Ragland JD, Moberg PJ, et al. Computerized neurocognitive scanning: I. Methodology and validation in healthy people. Neuropsychopharmacology. 2001;25:766–788. [PubMed] 188. Gur RC, Ragland JD, Moberg PJ, et al. Computerized neurocognitive scanning: II. The profile of schizophrenia. Neuropsychopharmacology. 2001;25:777–788. [PubMed] 189. Gur RE, Kohler C, Ragland JD, et al. Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia. Neuropsychopharmacology. 2003;28:2029–2036. [PubMed] 190. Kurtz MM, Ragland JD, Moberg PJ, Gur RC. The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms for repeat administration. Arch Clin Neuropsychol. 2004;19:191–201. [PubMed] 191. Ragland JD, Turetsky BI, Gur RC, et al. Working memory for complex figures: an fMRI comparison of letter and fractal N-back tasks. Neuropsychology. 2002;16:370–379. [PubMed] 192. Gur RC, Jaggi JL, Ragland JD, et al. Effects of memory processing on regional brain activation: cerebral blood flow in normal subjects. Int J Neurosci. 1993;72:31–44. [PubMed] 193. Glahn DC, Gur RC, Ragland JD, Gur RE. Reliability, performance characteristics, and construct validity and initial application of the visual object learning test (VOLT) Neuropsychology. 1997;11:602–612. [PubMed] 194. Kohler CG, Turner TH, Bilker WB, et al. Facial emotion recognition in schizophrenia: intensity effects and error pattern. Am J Psychiatry. 2003;160:1768–1774. [PubMed] 195. Conklin HM, Calkins ME, Anderson CW, III, Dinzeo TJ, Iacono WG. Recognition memory for faces in schizophrenia patients and their first-degree relatives. Neuropsychologia. 2002;40:2314–2324. [PubMed] 196. Hellewell JS, Connell J, Deakin JF. Affect judgement and facial recognition memory in schizophrenia. Psychopathology. 1994;27:255–261. [PubMed] 197. Calkins ME, Gur RC, Ragland JD, Gur RE. Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives. Am J Psychiatry. 2005;162:1963–1966. [PubMed] 198. Gur RE, Nimgaonkar VL, Almasy L, et al. Am J Psychiatry. Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. [PubMed] 199. Sachs G, Steger-Wuchse D, Kryspin-Exner I, Gur RC, Katschnig H. Facial recognition deficits and cognition in schizophrenia. Schizophr Res. 2004;68:27–35. [PubMed] 200. Erwin RJ, Gur RC, Gur RE, et al. Facial emotion discrimination: I. Task construction and behavioral findings in normal subjects. Psychiatry Res. 1992;42:231–240. [PubMed] 201. Schneider F, Gur RC, Gur RE, Shtasel DL. Emotional processing in schizophrenia: neurobehavioral probes in relation to psychopathology. Schizophr Res. 1995;17:67. [PubMed] 202. Kohler CG, Bilker W, Hagendoorn M, Gur RE, Gur RC. Emotion recognition deficit in schizophrenia: association with symptomatology and cognition. Biol Psychiatry. 2000;48:127–136. [PubMed] 203. Kohler CG, Turner TH, Gur RE, Gur RC. Recognition of facial emotions in neuropsychiatric disorders. CNS Spectr. 2004;9:267–274. [PubMed] 204. Mandal MK, Pandey R, Prasad AB. Facial expressions of emotions and schizophrenia: a review. Schizophr Bull. 1998;24:399–412. [PubMed] 205. Heimberg C, Gur RE, Erwin RJ, Shtasel DL, Gur RC. Facial emotion discrimination: III. Behavioral findings in schizophrenia. Psychiatry Res. 1992;42:253–265. [PubMed] 206. Habel U, Gur RC, Mandal MK, et al. Emotional processing in schizophrenia across cultures: standardized measures of discrimination and experience. Schizophr Res. 2000;42:57–66. [PubMed] 207. Silver H, Shlomo N, Turner T, Gur RC. Perception of happy and sad facial expressions in chronic schizophrenia: evidence for two evaluative systems. Schizophr Res. 2002;55:171. [PubMed] 208. Edwards J, Jackson HJ, Pattison PE. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clin Psychol Rev. 2002;22:789–832. [PubMed] 209. Schneider F, Gur RC, Koch K, et al. Impairment in the specificity of emotion processing in schizophrenia. Am J Psychiatry. 2006;163:442–447. [PubMed] 210. Gruzelier J, Wilson L, Richardson A. Cognitive asymmetry patterns in schizophrenia: retest reliability and modification with recovery. Int J Psychophysiol. 1999;34:323–331. [PubMed] 211. Edwards J, Pattison PE, Jackson HJ, Wales RJ. Facial affect and affective prosody recognition in first-episode schizophrenia. Schizophr Res. 2001;48:235–253. [PubMed] 212. Wolwer W, Streit M, Polzer U, Gaebel W. Facial affect recognition in the course of schizophrenia. Eur Arch Psychiatry Clin Neurosci. 1996;246:165–170. [PubMed] 213. Bediou B, Franck N, Saoud M, et al. Effects of emotion and identity on facial affect processing in schizophrenia. Psychiatry Res. 2005;133:149–157. [PubMed] 214. Cutting J. Judgement of emotional expression in schizophrenics. Br J Psychiatry. 1981;139:1–6. [PubMed] 215. Kucharska-Pietura K, David AS, Masiak M, Phillips ML. Perception of facial and vocal affect by people with schizophrenia in early and late stages of illness. Br J Psychiatry. 2005;187:523–528. [PubMed] 216. Gaebel W, Wolwer W. Facial expression and emotional face recognition in schizophrenia and depression. Eur Arch Psychiatry Clin Neurosci. 1992;242:46–52. [PubMed] 217. Kee KS, Kern RS, Marshall BD,, Jr, Green MF. Risperidone versus haloperidol for perception of emotion in treatment-resistant schizophrenia: preliminary findings. Schizophr Res. 1998;31:159–165. [PubMed] 218. McGue M, Bouchard TJ., Jr Genetic and environmental influences on human behavioral differences. Ann Rev Neurosci. 1998;21:1–24. [PubMed] 219. Plomin R, McGuffin P. Psychopathology in the postgenomic era. Ann Rev Psychol. 2003;54:205–228. [PubMed] 220. Gur RE, Kohler CG, Ragland JD, et al. Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures. Schizophr Bull. 2006;32:279–287. [PMC free article] [PubMed] 221. Toomey R, Seidman LJ, Lyons MJ, Faraone SV, Tsuang MT. Poor perception of nonverbal social-emotional cues in relatives of schizophrenic patients. Schizophr Res. 1999;40:121–130. [PubMed] 222. Bolte S, Poustka F. The recognition of facial affect in autistic and schizophrenic subjects and their first-degree relatives. Psychol Med. 2003;33:907–915. [PubMed]
223. McCown W, Johnson J, Austin S, Shefsky M. Deficits in ability to decode facial affects in families of schizophrenics. Psychother Priv Pract. 1988;6:93–101.
224. Kee KS, Horan WP, Mintz J, Green MF. Do the siblings of schizophrenia patients demonstrate affect perception deficits? Schizophr Res. 2004;67:87–94. [PubMed] 225. Yoo SS, Choi BG, Juh RH, et al. Working memory processing of facial images in schizophrenia: fMRI investigation. Int J Neurosci. 2005;115:351–366. [PubMed] 226. Gur RC, Schroeder L, Turner T, et al. Brain activation during facial emotion processing. Neuroimage. 2002;16:651. [PubMed] 227. van Rijn S, Aleman A, Swaab H, Kahn RS. Neurobiology of emotion and high risk for schizophrenia: role of the amygdala and the X-chromosome. Neurosci Biobehav Rev. 2005;29:385–397. [PubMed] 228. Gur RE, McGrath C, Chan RM, et al. An fMRI study of facial emotion processing in patients with schizophrenia. Am J Psychiatry. 2002;159:1992–1999. [PubMed] 229. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry. 2003;54:515–528. [PubMed] 230. Hariri AR, Drabant EM, Munoz KE, et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry. 2005;62:146–152. [PubMed] 231. Pezawas L, Meyer-Lindenberg A, Drabant EM, et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005;8:828–834. [PubMed] 232. Aliyu MH, Calkins ME, Swanson CL. Project among African Americans to explore risks for schizophrenia: assessment and recruitment methods. Schizophr Res. 2006;87:32–44. [PubMed] 233. Gladsjo JA, McAdams LA, Palmer BW, et al. A six-factor model of cognition in schizophrenia and related psychotic disorders: relationships with clinical symptoms and functional capacity. Schizophr Bull. 2004;30:739–754. [PubMed] 234. Dickinson D, Ragland JD, Calkins ME, Gold JM, Gur RC. A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophr Res. 2006;85:20–29. [PubMed]