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Logo of behbrainBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBehavioral and Brain Functions : BBFJournal Front Page
 
Behav Brain Funct. 2008; 4: 57.
Published online Dec 22, 2008. doi:  10.1186/1744-9081-4-57
PMCID: PMC2621224
Asymmetry in the brain influenced the neurological deficits and infarction volume following the middle cerebral artery occlusion in rats
Huanmin Gaocorresponding author1 and Meizeng Zhangcorresponding author2
1Department of Neurology, the Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, PR China
2Department of Neurology, Affiliated Hospital of Qingdao University Medical College, 16 Jiang Su Road, Qingdao 266003, PR China
corresponding authorCorresponding author.
Huanmin Gao: huanmgao/at/yahoo.com.cn; Meizeng Zhang: zmzcmd/at/yahoo.com.cn
Received February 19, 2008; Accepted December 22, 2008.
Abstract
Background
Paw preference in rats is similar to human handedness, which may result from dominant hemisphere of rat brain. However, given that lateralization is the uniqueness of the humans, many researchers neglect the differences between the left and right hemispheres when selecting the middle cerebral artery occlusion (MCAO) in rats. The aim of this study was to evaluate the effect of ischemia in the dominant hemisphere on neurobehavioral function and on the cerebral infarction volume following MCAO in rats.
Methods
The right-handed male Sprague-Dawley rats asserted by the quadrupedal food-reaching test were subjected to 2 hours MCA occlusion and then reperfusion.
Results
The neurological scores were significantly worse in the left MCAO group than that in the right MCAO group at 1 h, 24 h, 48 h and 72 h (p <0.05 respectively). There was a trend toward better neurobehavioral function recovery in the right MCAO group than in the left MCAO group. The total infarct volume in left MCAO was significantly larger than that in the right (p < 0.05).
Conclusion
The neurobehavioral function result and the pathological result were consistent with the hypothesis that paw preference in rats is similar to human handedness, and suggested that ischemia in dominant hemisphere caused more significant neurobehavioral consequence than in another hemisphere following MCAO in adult rats. Asymmetry in rat brain should be considered other than being neglected in choice of rat MCAO model.
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