Search tips
Search criteria 


Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. 1985 September; 49(3): 836–837.
PMCID: PMC261291

Measurement of streptococcal cell wall in tissues of rats resistant or susceptible to cell wall-induced chronic erosive arthritis.


The quantity of streptococcal cell wall localized in the joints of rats of strains which are either susceptible (Sprague-Dawley, LEW/N, M520/N) or resistant (Buffalo, WKY/N, F344/N) to cell wall-induced chronic erosive arthritis was measured after intraperitoneal injection of group A streptococcal cell wall fragments. Susceptibility or resistance was not associated with a difference in the amount of cell wall localized in limbs or other tissues. It is concluded that although localization of cell wall in joint tissue is essential for development of arthritis, the relative resistance of certain rat strains reflects genetic regulation of inflammatory response rather than a quantitative difference in localization of cell wall in joints.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (336K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Anderle SK, Greenblatt JJ, Cromartie WJ, Clark R, Schwab JH. Modulation of the susceptibility of inbred and outbred rats to arthritis induced by cell walls of group A streptococci. Infect Immun. 1979 Aug;25(2):484–490. [PMC free article] [PubMed]
  • Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, Yang CH. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J Exp Med. 1977 Dec 1;146(6):1585–1602. [PMC free article] [PubMed]
  • Dalldorf FG, Cromartie WJ, Anderle SK, Clark RL, Schwab JH. The relation of experimental arthritis to the distribution of streptococcal cell wall fragments. Am J Pathol. 1980 Aug;100(2):383–402. [PubMed]
  • Eisenberg R, Fox A, Greenblatt JJ, Anderle SK, Cromartie WJ, Schwab JH. Measurement of bacterial cell wall in tissues by solid-phase radioimmunoassay: correlation of distribution and persistence with experimental arthritis in rats. Infect Immun. 1982 Oct;38(1):127–135. [PMC free article] [PubMed]
  • Fox A, Brown RR, Anderle SK, Chetty C, Cromartie WJ, Gooder H, Schwab JH. Arthropathic properties related to the molecular weight of peptidoglycan-polysaccharide polymers of streptococcal cell walls. Infect Immun. 1982 Mar;35(3):1003–1010. [PMC free article] [PubMed]
  • Lehman TJ, Allen JB, Plotz PH, Wilder RL. Lactobacillus casei cell wall-induced arthritis in rats: cell wall fragment distribution and persistence in chronic arthritis-susceptible LEW/N and -resistant F344/N rats. Arthritis Rheum. 1984 Aug;27(8):939–942. [PubMed]
  • Wilder RL, Calandra GB, Garvin AJ, Wright KD, Hansen CT. Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 1982 Sep;25(9):1064–1072. [PubMed]
  • Wilder RL, Allen JB, Wahl LM, Calandra GB, Wahl SM. The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. Arthritis Rheum. 1983 Dec;26(12):1442–1451. [PubMed]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)