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Appl Environ Microbiol. 2009 January; 75(1): 261–264.
Published online 2008 November 14. doi:  10.1128/AEM.00261-08
PMCID: PMC2612206

Oxygen-Mediated Regulation of Biofilm Development Is Controlled by the Alternative Sigma Factor σB in Staphylococcus epidermidis


Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of σB. Under anaerobic conditions, increased σB activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)