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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Int J Obes (Lond). Author manuscript; available in PMC Jun 1, 2009.
Published in final edited form as:
PMCID: PMC2605208
NIHMSID: NIHMS70681

The Association between Sleep Duration and Obesity in Older Adults

Sanjay R. Patel, MD MS,1 Terri Blackwell, MA,2 Susan Redline, MD MPH,1 Sonia Ancoli-Israel, PhD,3 Jane A. Cauley, DrPh,4 Teresa A. Hillier, MD MS,5 Cora E. Lewis, MD,6 Eric S. Orwoll, MD,7 Marcia L. Stefanick, PhD,2 Brent C. Taylor, PhD,8 Kristine Yaffe, MD,9 Katie L. Stone, PhD,2 for the Osteoporotic Fractures in Men (MrOS), and the Study of Osteoporotic Fractures (SOF) Research Groups

Abstract

Background

Reduced sleep has been reported to predict obesity in children and young adults. However, studies based on self-report have been unable to identify an association in older populations. In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults.

Methods

Wrist actigraphy was performed for a mean (SD) of 5.2 (0.9) nights in 3055 men (age: 67–96 years) participating in the Osteoporotic Fractures in Men Study (MrOS) and 4.1 (0.8) nights in 3052 women (age: 70–99 years) participating in the Study of Osteoporotic Fractures (SOF). A subgroup of 2862 men and 455 women also underwent polysomnography to measure sleep apnea severity.

Results

Compared to those sleeping an average of 7–8 hours per night, and after adjusting for multiple risk factors and medical conditions, a sleep duration of less than 5 hours was associated with a body mass index (BMI) that was on average 2.5 kg/m2 (95% CI: 2.0–2.9) greater in men and 1.8 kg/m2 (95%CI: 1.1–2.4) greater in women. The odds of obesity (BMI ≥ 30 kg/m2) was 3.7-fold greater (95% CI: 2.7–5.0) in men and 2.3-fold greater in women (95% CI: 1.6–3.1) who slept less than 5 hours. Short sleep was also associated with central body fat distribution and increased percent body fat. These associations persisted after adjusting for sleep apnea, insomnia, and daytime sleepiness.

Conclusions

In older men and women, actigraphy-ascertained reduced sleep durations are strongly associated with greater adiposity.

Keywords: sleep duration, sleep deprivation, obesity, central obesity, geriatrics, insomnia, sleepiness

Introduction

Obesity has become a global epidemic. The prevalence of adult obesity in the US has more than doubled from 15% in the late 1970s to 31% by 2000.1 Parallel to the increase in weight has been a reduction in sleep times. Only 35% of American adults reported obtaining 8 hours of sleep in 1998 and that number had further fallen to 26% by 2005.2

Multiple studies of children and young adults have observed an association between reduced sleep time and increased weight, suggesting that those who report sleeping less are more likely to be obese.36 However, critical reviews of this literature have pointed out substantial weaknesses in this evidence including the overwhelming reliance on self-report for sleep duration, inadequate length of monitoring when objective measurements of sleep were performed, and inadequate control for important potential confounders such as sleep apnea and depression that can adversely impact both sleep duration and weight.79 In addition, several studies have suggested that the association between short sleep and obesity does not exist or weakens at older ages.10, 11 However, the reliance on self-report to assess sleep duration may lead to substantial misclassification, particularly in older populations where sleep disorders such as insomnia and sleep apnea are common leading to misperception of time spent asleep. A recent study using objective measurement of sleep duration over multiple nights in the elderly did find a strong association between reduced sleep and obesity while no association was found in this same cohort when reduced sleep was defined based on self-report.12

The prevalence of obesity in those over 60 is similar to the overall adult prevalence.13 Older populations also suffer from a high prevalence of diabetes, hypertension, and heart disease, conditions which are causally linked to, or exacerbated by, obesity. Furthermore, sleep difficulties increase in prevalence with age making reduced sleep durations potentially much more common in this group. Using cross-sectional data derived from two multi-center observational studies in older populations, we performed one of the first assessments of the relationship between objectively measured sleep duration and obesity in an older population with detailed evaluation of whether any identified association is independent of sleep apnea, daytime sleepiness and insomnia.

Methods

Study Population

Men were participants in the prospective Osteoporotic Fractures in Men Study (MrOS). During the baseline examination from 2000 to 2002, 5995 community-dwelling men 65 years or older were enrolled at 6 clinical centers in the United States: Birmingham, Alabama; Minneapolis, Minnesota; Palo Alto, California; Pittsburgh, Pennsylvania; Portland, Oregon; and San Diego, California. The MrOS Sleep Study, an ancillary study of the parent MrOS cohort, was conducted between December 2003 and March 2005 and recruited 3135 of these participants (exceeding the goal of 3000 participants) for a comprehensive sleep assessment of whom 3110 underwent actigraphy. Of the 2860 participants who did not participate in the sleep study; 1997 were unwilling, 332 were not screened because recruitment goals were met, 344 died before the sleep study visit, 150 were ineligible due to exclusion criteria and 37 withdrew from the study before the sleep visit.

Women were participants in the prospective Study of Osteoporotic Fractures (SOF). During the baseline examination from 1986 to 1988, 9704 community-dwelling white women 65 years or older were enrolled from population-based listings in 4 areas of the United States: Baltimore, Maryland; Minneapolis, Minnesota; Pittsburgh, Pennsylvania; and Portland, Oregon. An additional 662 African-American women were enrolled between 1997 and 1998. Assessment of sleep occurred during the 8th examination in this cohort which took place from January 2002 to April 2004. A total of 4727 women (84% of survivors) participated, of whom 3676 had a clinical visit and 3219 underwent actigraphy.

For both studies, individuals were not eligible to participate if they reported bilateral hip replacement or required the assistance of another person in ambulation at the baseline examination. Details of the cohorts have been published.1416 The protocol for MrOS and SOF were approved by the institutional review boards at all of the participating institutions. All participants provided written informed consent.

Sleep Duration

Average nightly sleep duration was obtained using wrist actigraphy (Sleepwatch-O, Ambulatory Monitoring, Inc., Ardsley NY) in both cohorts. The actigraph, which measures acceleration using a piezoelectric biomorph-ceramic cantilevered beam, was worn on the wrist of the non-dominant hand. Subjects were asked to wear the actigraph a minimum of 5 nights in MrOS and 3 nights in SOF. Average use (SD) was 5.2 (0.9) nights in MrOS and 4.1 (0.8) nights in SOF. Data were collected continuously and stored in 1-minute epochs. The digital integration mode of analysis, which sums the absolute level of acceleration on a second by second basis over the epoch, was used to quantify the amount of movement in each minute from which sleep-wake status could be inferred. This technique for estimating sleep duration has been validated against polysomnography in these cohorts.17, 18 Action W-2 software (Ambulatory Monitoring, Inc.) was used to analyze the raw data,19 and the University of California San Diego scoring algorithm was used to determine sleep/wake status.20

While wearing the actigraph, participants completed sleep diaries which included time into and time out of bed and times the actigraph was removed. This information was used in editing the actigraphy data files to set intervals for when the participant was in bed, and to delete time when the actigraph was removed from analyses. Actigraphy is most accurate in distinguishing wake from sleep at night, thus nocturnal sleep duration (amount of sleep obtained between time to bed and time out of bed) was used as the primary measure of sleep duration (averaged across all nights of measurement). Inter-scorer reliability for this measure has been previously found to be high in our group (intra-class coefficient = 0.95) and this measure has been shown to have good concordance with total sleep time from polysomnography.12, 21 Nocturnal sleep duration was categorized into < 5 hrs, 5 to < 7 hrs, 7 to < 8 hrs, and ≥ 8 hrs. Secondary analyses were conducted using the total amount of sleep across a 24-hour period from 9 a.m. to 9 a.m., again averaging over all days of measurement. Because few subjects had a 24-hr sleep time below 5 hrs when napping was included, the categories used for these analyses were < 6 hrs, 6 to < 7 hrs, 7 to < 8 hrs, and ≥ 8 hrs. Because of potential differences between weeknight and weekend sleep patterns, secondary analyses were performed limiting sleep data to that collected on weeknights (Sunday to Thursday nights).

Obesity and Body Fat Measures

During the home or clinic visits, body weight was measured with a standard balance beam or digital scale, height with a wall-mounted Harpenden stadiometer (Holtain, England), and these measurements were used to calculate body mass index (BMI). Obesity was defined as a BMI ≥ 30 kg/m2. Circumferences at the hip and waist were also measured in a standardized fashion for all men in MrOS and for the subset of women in SOF who underwent polysomnography (see below). In the MrOS cohort, percent body fat and percent lean mass were obtained for the entire body as well as specific to the trunk using dual energy x-ray absoptiometry (DXA; Hologic QDR-4500 W, Bedford, MA).

Covariates

All participants completed questionnaires, which included items about demographics, medical history, physical activity, smoking and alcohol use. Caffeine consumption was estimated based on self-report of the average daily number of cups of caffeinated coffee and tea, or cans of caffeinated soda consumed. Participants were asked to bring in all current medications used within the preceding 30 days. All prescription medications were entered into an electronic database and each medication was matched to its ingredient(s) based on the Iowa Drug Information Service (IDIS) Drug Vocabulary (College of Pharmacy, University of Iowa, Iowa City, IA).22 The Geriatric Depression Scale (GDS) was used to assess depressive symptoms, and the standard cutoff of six or more symptoms was used to define depression.23 In MrOS, level of activity was assessed using the Physical Activity Scale for the Elderly,24 while in SOF, physical activity was assessed by asking women if they walked for exercise.

Self-reported information about sleepiness was assessed using the Epworth Sleepiness Scale (ESS).25 An ESS >10 was used to define excessive daytime sleepiness.26 The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality.27 Insomnia was defined as either taking more than 30 minutes to fall asleep or waking up in the middle of the night three or more times a week based on responses to the PSQI.

In-home sleep studies using unattended polysomnography (SOF: Siesta unit; MrOS: Safiro unit; Compumedics, Abbotsford, Australia) were performed in 2956 MrOS participants and a subset of 461 women in SOF recruited from two clinical centers (Minneapolis and Pittsburgh). The recording montage was identical and included C3/A2 and C4/A1 electroencephalography, bilateral electrooculography, submental electromyography, thoracic and abdominal respiratory effort, airflow (nasal-oral thermocouple and nasal pressure), finger pulse oximetry, electrocardiography, body position, and bilateral leg movements. Sleep staging was done using standard criteria.28 Apneas were defined as a complete or almost complete cessation of airflow for more than 10 seconds. Hypopneas were defined as a > 30% reduction in amplitude of either respiratory effort or airflow for more than 10 seconds associated with a ≥ 3% oxygen desaturation. The apnea hypopnea index (AHI) was computed as the average number of apneas and hypopneas per hour of recorded sleep. An AHI ≥ 15 was used to define moderate to severe sleep apnea.29

Statistical Analyses

Each cohort was analyzed separately but in parallel fashion. Baseline characteristics were summarized by category of sleep duration at night and differences were compared using analysis of variance for normally distributed continuous data, Kruskal-Wallis tests for continuous skewed data, and chi-square tests for categorical data.

Multivariate regression models were used to assess the independent relationship between sleep duration measures (average sleep duration at night and average sleep duration over 24-hours) with each of the weight-related outcomes using linear regression for continuous outcomes and logistic regression for the dichotomous outcome of obesity. Covariates were selected based on being associated with both sleep duration and obesity in prior studies. All models included study site, age, race (Caucasian vs. non-Caucasian), level of education (< 12 years, 12–16 years, > 16 years), history of diabetes, stroke, heart disease (angina, myocardial infarction, heart failure, coronary revascularization procedure, or pacemaker placement), use of antidepressants, use of benzodiazepines, smoking status (never, past, current), alcohol consumption (continuous), caffeine consumption (continuous), current depression (by GDS), and level of physical activity (continuous in MrOS and dichotomous in SOF) as covariates. Additional analyses adjusted for AHI to control for sleep apnea severity. Evidence for effect modification was assessed by stratifying analyses based on sleepiness or insomnia symptoms as well as by assessing the significance of an interaction term with sleep duration. All analyses were performed using SAS statistical software (version 9.1, SAS Institute, Inc., Cary, North Carolina).

Results

A total of 3055 men (mean age 76.4 y) and 3052 women (mean age 83.6 y) had actigraphic data of sufficient quality to be included in these analyses (98% and 95% of the sample studied respectively). On average, nocturnal sleep duration (mean ± SD) was 384 ± 74 min for the men in MrOS and 405 ± 78 min for the women in SOF. In these elderly cohorts, mean sleep duration was similar on weeknights versus weekends (381 min vs. 390 min in MrOS and 404 min vs. 407 min in SOF). Baseline data on each cohort by nocturnal sleep duration are shown for men in Table 1 and for women in Table 2. Among both men and women, short sleepers (< 5 hours) were more likely to have co-morbidities. Antidepressant use was more common among both short and long sleepers. Among men, short sleep was associated with lower levels of education and greater rates of cigarette smoking. In both genders, short sleep duration was associated with increased prevalence of sleep apnea and symptoms of sleepiness. In contrast, no clear association was found between sleep duration and insomnia symptoms.

Table 1
Demographic characteristics among men in the MrOS cohort by sleep duration.
Table 2
Demographic characteristics among women in the SOF cohort by sleep duration.

In both men and women, mean BMI was greatest in those sleeping the least (Figure 1). In multivariable analyses, mean BMI was 2.48 kg/m2 (95% CI: [2.02, 2.93]) greater in men and 1.75 kg/m2 [1.09, 2.42] greater in women among those sleeping less than 5 hours compared to those with 7–8 hours of sleep (p<0.0001 for both men and women). Short sleepers were also found to have greater waist circumference (Figure 2). Relative to 7–8 hour sleepers, men sleeping less than 5 hours had a 6.7 cm [5.4, 8.0] greater waist circumference while in women this difference was 5.4 cm [1.0, 9.9] (p<0.0001 for men and p<0.02 for women). Hip circumference was 4.7 cm [3.7, 5.7] and 5.0 cm [1.0, 8.9] greater in short sleepers in men and women respectively (p<0.0001 for men and p<0.02 for women).

Figure 1
Association between body mass index and sleep duration among older men and women
Figure 2
Association between waist circumference and sleep duration among older men and women

Results from men in MrOS, for whom DXA measures of total and body regional fat were obtained, suggested the increases in these measures were due to increases in fat mass (Figure 3). Percent body fat was 1.7% [1.1, 2.4] greater and percent body fat in the trunk was 1.9% [1.1, 2.7] greater in those sleeping less than 5 hours compared to those with 7–8 hours of sleep (p<0.0001 for both comparisons). In fact, the relationship between percent body fat and sleep duration exhibited a U-shaped association such that compared to those with 7–8 hours of sleep, men sleeping 8 hours or more had 0.9% [0.1, 1.7] greater overall percent body fat (p=0.03) and 1.2% [0.3, 2.1] greater percent body fat in the trunk (p=0.01).

Figure 3
Association between percent body fat and sleep duration among older men

Short sleep durations were also associated with increased likelihood of obesity (Table 3). Relative to those sleeping 7–8 hours, men sleeping less than 5 hours were 3.7 [2.7, 5.0] times more likely to be obese and women sleeping less than 5 hours were 2.3 [1.6, 3.1] times more likely to be obese. The odds ratios for obesity associated with sleeping 5–7 hours were 1.5 [1.2, 1.9] and 1.3 [1.0, 1.6] for men and women respectively.

Table 3
Association between sleep duration and obesity among older men and women.

In order to assess whether the association between sleep duration and obesity was explained by sleep apnea, secondary analyses were performed adjusting for AHI (Table 3). Among men, the odds of obesity increased 1.4-fold [1.3, 1.5] with every 10 unit increase in AHI. Adjusting for AHI attenuated the association between short sleep and obesity by 18%; however, a significant association persisted. Mean BMI was 2.03 kg/m2 [1.57, 2.48] greater and the odds ratio for obesity was 3.0 [2.2, 4.2] in those sleeping less than 5 hours compared to 7–8 hour sleepers. Additional analyses were performed restricting to those individuals with an AHI < 15. In this subgroup, short sleep remained associated with greater adiposity. Among men, mean BMI was 1.99 kg/m2 [1.36, 2.63] greater among short sleepers and the odds ratio for obesity in short sleepers was 2.7 [1.6, 4.5]. Although the sample size was much smaller in SOF due to the limited number of sleep studies performed, the patterns were very similar in women (i.e., the association between short sleep and obesity was attenuated by 14% after adjusting for AHI).

Among men, neither daytime sleepiness nor insomnia symptoms were associated with obesity after controlling for sleep duration. Stratified analyses found similar associations between short sleep and obesity in men with and without excessive daytime sleepiness and with and without insomnia (Table 4). Among women, sleepiness was also not associated with obesity but insomnia was an independent predictor with an OR of 1.3 [1.1, 1.6]. In stratified analyses, the association between short sleep and obesity appeared stronger among women with daytime sleepiness and women with insomnia. However, formal statistical testing of an interaction between daytime sleepiness and sleep duration or insomnia and sleep duration was not significant.

Table 4
Association between sleep duration and obesity among older men and women stratified by self-reported sleep symptoms.

Using total sleep time over the 24-hr period as the sleep duration measure instead of nocturnal sleep time had no substantial effect on the relationships found. In multivariate models, mean BMI was 1.54 kg/m2 greater [1.10, 1.97] among men and 1.23 kg/m2 greater [0.56, 1.90] among women with a 24-hr sleep duration less than 6 hours compared to 7–8 hours (p<0.0001 for men and p<0.001 for women). The odds ratios for obesity in those sleeping less than 6 hours relative to those sleeping 7–8 hours were 2.4 [1.8, 3.2] and 1.7 [1.2, 2.4] in men and women respectively. The association between nocturnal sleep duration and obesity measures was similar when restricted to data obtained on weeknights (data not shown).

Discussion

In both the MrOS and SOF cohorts, we found that older men and women with reduced amounts of sleep as measured by actigraphy had an elevated body mass index. Sleeping 5 or fewer hours per night was associated with a 3.7-fold greater odds of obesity among men and 2.3-fold increase among women compared to those sleeping 7–8 hours per night. Sleep disturbances are extremely common in older populations. Epidemiologic data indicate that 12–54% of older individuals report symptoms of sleep difficulties on a consistent basis.30, 31 As a result, any causal relationship between disrupted sleep and obesity would have substantial importance from a public health standpoint.

Not only was short sleep duration associated with increased BMI, it was associated with an increased fat mass, supporting a role for chronic sleep restriction in obesity pathogenesis. Furthermore, reduced sleep was associated with increased waist circumference and truncal fat suggesting an association with central abdominal fat, the fat depot most strongly associated with diabetes and cardiovascular morbidity.3234 Although our results suggest a stronger association between short sleep and obesity in men, direct comparison is not possible as the women (SOF cohort) were nearly a decade older than the men (MrOS cohort).

Sleeping more than 8 hours was also associated with increased truncal and total body fat in the MrOS cohort. In addition, a similar (but non-significant trend) towards a U-shaped association between sleep duration and obesity risk, BMI, waist and hip circumferences was found in MrOS. In contrast, an inverse linear association appears to exist between sleep duration and adiposity measures in the SOF cohort. This difference in patterns may be due to gender differences in susceptibility to altered sleep habits as has been suggested in some recent studies,35, 36 but again, this may also reflect differences in age or other factors between the two cohorts.

Our findings suggest a strong association between reduced sleep times and obesity in older populations. This work is one of the first analyzing the relationship between sleep duration and obesity to use actigraphy in order to objectively measure sleep duration and to do so in older adults. In the vast majority of prior studies on the association between sleep and adiposity, sleep duration has been assessed on the basis of self-report. The validity of self-report is unclear. It has been argued that questions about usual sleep time may measure overall health rather than sleep duration itself.37 Evidence for systematic bias in self-reported sleep questions exists as responses overestimate the amount of sleep compared to measurements made by actigraphy or polysomnography.38, 39

Our findings stand in contrast to prior reports on the relationship between sleep and obesity in older populations. Data from the National Health and Nutrition Examination Survey (NHANES I) suggested that though obesity was associated with reduced self-reported sleep durations in younger adults, no relationship existed in those over age 50.10 A European population-based telephone surveys of adults over age 55 found obesity was not an independent predictor of self-reported sleep duration.11 In contrast, our results are very similar to those from a recent study of 983 older Dutch adults that also used actigraphy to quantify sleep duration.12 Averaging across men and women, sleeping less than 5 h was associated with a 1.6 kg/m2 greater BMI and a 2.8 greater odds of obesity in that cohort.

Our work is also the first in the field to formally assess sleep apnea severity and to assess the relationship between sleep duration and obesity independent of this factor which may lead to a causal relationship in the opposite direction (obesity predisposes to sleep apnea which causes reduced sleep durations). Sleep apnea is highly prevalent in older adults,40 and associated with both reduced sleep times and obesity.41, 42 Prior research has ignored this explanatory pathway or attempted to address it by use of data on self-reported snoring or prior physician diagnosis of sleep apnea.43, 44 However, these measures are insensitive and do not capture severity of sleep apnea. In these analyses, particularly in men, we were able to demonstrate a modest attenuation of the association between reduced sleep and obesity after adjusting for sleep apnea severity suggesting a portion of the association can be explained by this pathway. However, we demonstrated a significant association between short sleep and obesity persisted after controlling for AHI or after restricting analyses to those without significant sleep apnea.

Sleep duration may vary in association with many underlying risk factors and medical and psychiatric conditions. Standardized collection of a broad variety of data allowed us to adjust for factors such as depression, physical activity, medication use and chronic illnesses. We extended prior work by systematically assessing the consistency of associations in groups with and without insomnia and with and without sleepiness. In men, only minor differences in the magnitude of association between short sleep and obesity were observed regardless of reported sleepiness or insomnia symptoms. In contrast, larger effects were suggested among women with sleep symptoms. The significance of these differences, however, was not supported by finding a statistically significant interaction term, and overall, our findings suggest that the effect of sleep deprivation on weight regulation is likely to be independent of the etiology of the reduced sleep (e.g., insomnia vs. voluntary curtailment of sleep).

It has been reported in an elderly cohort where sleep was based on self-report that while a short nighttime sleep duration is associated with obesity, the obese are more likely to take daytime naps so that overall sleep duration for a 24-hr period is not associated with obesity.45 In contrast, in this study using actigraphy to assess sleep duration, reduced nighttime sleep duration and reduced 24-hr sleep duration were both associated with elevated BMI.

Our study has many strengths, including large cohorts of men and women, objective measures of sleep duration using actigraphy, comprehensive assessments of BMI and body composition, and collection of important covariates such as severity of sleep apnea. Several limitations should also be recognized. We cannot exclude the potential for selection bias as the frailest subjects in the parent cohorts were probably less likely to participate in the sleep assessments. In addition, because this work is cross-sectional, a causal direction cannot be definitively established. However, experimental work has confirmed that sleep deprivation can have metabolic effects that may be relevant to weight homeostasis. Two nights of sleep restriction to 4 hours per night has been found to lead to reductions in circulating leptin, elevations in ghrelin, and increases in self-report of hunger and appetite.46

Sleep disruption and reduced sleep times are highly prevalent in older populations. In fact, it is commonly suggested that reduced sleep is a normal part of aging. Our data would suggest that reduced sleep is associated with obesity in older cohorts to a similar extent as that observed in children and younger adults. Given the greater prevalence of obesity-related complications including diabetes, cardiovascular disease, and cancer, the importance of ensuring adequate sleep may actually be more important from a morbidity standpoint in this age group. Our work underscores the need for further research including longitudinal studies with repeated measures of both sleep and weight over time as well as interventional studies where sleep duration is manipulated in order to better define whether poor sleep predisposes to adverse metabolic consequences in older populations.

Acknowledgments

In addition to the support below, this work was supported by National Institutes of Health grant HL081385. The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA), the National Center for Research Resources (NCRR), and NIH Roadmap for Medical Research under the following grant numbers: AR045580, AR045614, AR045632, AR045647, AR045654, AR045583, AG018197, AG027810, and RR024140. The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study “Outcomes of Sleep Disorders in Older Men” under the following grant numbers: HL071194, HL070848, HL070847, HL070842, HL070841, HL070837, HL070838, and HL070839. The Study of Osteoporotic Fractures (SOF) is supported by National Institutes of Health funding. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute on Aging (NIA) under the following grant numbers: AG005407, AR035582, AG005394, AR035584, AR035583, AG027576, AG005394, AG027574, and AG026720.

Footnotes

Disclosures: Drs. Patel, Redline, Ancoli-Israel, Cauley, Hillier, Lewis, Stefanick, Taylor, and Yaffe and Ms. Blackwell have no financial disclosures to report. Dr. Orwoll has received honoraria from Merck and is a paid consultant for Merck, Eli Lilly & Co, and Servier. He has active research support from Amgen, Eli Lily & Co. and Solvay Pharmaceuticals and has had prior research support from Pfizer, Zelos Therapeutics, and Imaging Therapeutics. Dr. Stone is a paid consultant for Sepracor and a paid speaker for Sanofi-Aventis.

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