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Infect Immun. Dec 1988; 56(12): 3326–3328.
PMCID: PMC259746
Plasmodium chabaudi malaria: protective immunization with surface membranes of infected erythrocytes.
F Wunderlich, H H Brenner, and M Helwig
Division of Parasitology, University of Duesseldorf, Federal Republic of Germany.
Plasmodium chabaudi-susceptible NMRI and B10.A mice were vaccinated with host cell plasma membranes isolated from P. chabaudi-infected erythrocytes. Most of the mice were protected from the lethal consequences of challenge with the homologous parasite, although protection was unassociated with a reduction in the course or peak of parasitemia. Vaccination also induced the production of antibodies against Pc90, which is the immunodominant protein expressed by parasites in host cell plasma membranes.
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