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Logo of behbrainBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBehavioral and Brain Functions : BBFJournal Front Page
 
Behav Brain Funct. 2008; 4: 52.
Published online Nov 18, 2008. doi:  10.1186/1744-9081-4-52
PMCID: PMC2596773
High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study
Osman Virit,1 Salih Selek,corresponding author2 Mahmut Bulut,1 Haluk Asuman Savas,1 Hakim Celik,3 Ozcan Erel,3 and Hasan Herken4
1Department of Psychiatry, Medical Faculty, Gaziantep University, Gaziantep, Turkey
2Department of Psychiatry, Kahramanmaras State Hospital, Kahramanmaras, Turkey
3Department of Clinical Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey
4Department of Psychiatry, Medical Faculty, Pamukkale University, Denizli, Turkey
corresponding authorCorresponding author.
Osman Virit: drosmanvirit/at/yahoo.com.tr; Salih Selek: drselek/at/hotmail.com; Mahmut Bulut: drmahmutbulut/at/yahoo.com; Haluk Asuman Savas: drhaluksavas/at/yahoo.com; Hakim Celik: hakimcell/at/yahoo.com; Ozcan Erel: erelozcan/at/yahoo.com; Hasan Herken: hasanherken/at/yahoo.com
Received June 1, 2008; Accepted November 18, 2008.
Abstract
Background
Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Several studies indicate that elevated serum ceruloplasmin levels may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. No study investigating the relationship between ceruloplasmin and obsessive-compulsive disorder (OCD) has been published to date. Nowadays OCD is increasingly speculated to be a different disorder than other anxiety disorders, and rather is considered to be more similar to psychotic disorders. The objective of this study to explore whether there is an association of ceruloplasmin with OCD as in schizophrenia.
Method
26 pure OCD and 9 co-morbid OCD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinics, diagnosed according to the DSM IV and 40 healthy controls were included in the study. Blood samples were collected; ceruloplasmin levels were measured.
Results
The mean ceruloplasmin level in pure OCD patients, co-morbid OCD patients, and control group persons were 544.46 ± 26.53, 424.43 ± 31.50 and 222.35 ± 8.88 U/L respectively. Results of all 3 groups differ significantly. Positive predictive value of ceruloplasmin for that cut-off point is 31/31 (100%) and negative predictive value is 40/44 (91%) in our group.
Conclusion
Although the nature of relationship is not clear there was an association between ceruloplasmin levels and OCD in our study.
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