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Yale J Biol Med. 1977 Jan-Feb; 50(1): 1–16.
PMCID: PMC2595308
Endocrine Dysfunction and Slipped Capital Femoral Epiphysis 1
John A. Ogden and Wayne O. Southwick
1Supported in part by grants from the Crippled Children's Aid Society, The Charles W. Ohse Fund, the Easter Seal Research Society and NIH Grant Tl AM 05416.
Abstract
Five patients with concomitant endocrinopathy and slipped capital femoral epiphysis were studied in detail. One had diabetes and hypothyroidism, one had hypothyroidism, one had hypergonadotropic hypogonadism and two had a craniopharyngioma (one of whom had severe panhypopituitarism post-operatively). An additional seven patients with cranio-pharyngioma revealed marked delay in closure of epiphyses and an additional undiagnosed case of slipped capital femoral epiphysis. Of the six patients with slipped capital femoral epiphysis, three had bilateral and three unilateral involvement. Of the five patients undergoing surgical stabilization, there was significant delay of epiphyseodesis, prompting us to recommend concomitant bone grafting. Histological examination of the femoral head from a three year old child with panhypopituitarism showed marked irregularity of the growth plate and loss of columnar integrity, which may be a predisposing factor to slipping in older children with endocrinopathies. The effects of various hormones on the physis are specifically discussed, especially as they relate to the possible etiology of slipped capital femoral epiphysis.
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