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Yale J Biol Med. 1990 Jan-Feb; 63(1): 9–13.
PMCID: PMC2589255

Fatal subcutaneous aspergillosis following necrotizing fasciitis: a case report.


Skin or subcutaneous infection with aspergillus is uncommon. It has been described in disseminated aspergillosis, as localized infection in the immunocompromised host and as a complication of trauma and burns. Described in this paper is a diabetic patient who developed a fatal Aspergillus infection following debridement of a necrotizing fasciitis. "Fruiting bodies," rarely found in vivo, were seen on pathologic examination of subcutaneous tissue. Her course was similar to that of burn patients with invasive fungal disease, where mortality is high and radical debridement is the only chance for cure.

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Selected References

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  • Young RC, Bennett JE, Vogel CL, Carbone PP, DeVita VT. Aspergillosis. The spectrum of the disease in 98 patients. Medicine (Baltimore) 1970 Mar;49(2):147–173. [PubMed]
  • Karam GH, Griffin FM., Jr Invasive pulmonary aspergillosis in nonimmunocompromised, nonneutropenic hosts. Rev Infect Dis. 1986 May-Jun;8(3):357–363. [PubMed]
  • D'Silva H, Burke JF, Jr, Cho SY. Disseminated aspergillosis in a presumably immunocompetent host. JAMA. 1982 Sep 24;248(12):1495–1497. [PubMed]
  • Fisher BD, Armstrong D, Yu B, Gold JW. Invasive aspergillosis. Progress in early diagnosis and treatment. Am J Med. 1981 Oct;71(4):571–577. [PubMed]
  • Vainrub B, Macareno A, Mandel S, Musher DM. Wound zygomycosis (mucormycosis) in otherwise healthy adults. Am J Med. 1988 Mar;84(3 Pt 1):546–548. [PubMed]
  • Prystowsky SD, Vogelstein B, Ettinger DS, Merz WG, Kaizer H, Sulica VI, Zinkham WH. Invasive aspergillosis. N Engl J Med. 1976 Sep 16;295(12):655–658. [PubMed]
  • CHEETHAM HD. SUBCUTANEOUS INFECTION DUE TO ASPERGILLUS TERREUS. J Clin Pathol. 1964 May;17:251–253. [PMC free article] [PubMed]
  • Suseelan AV, Gugnani HC, Ojukwu JO. Letter: Primary cutaneous aspergillosis due to Aspergillus terreus. Arch Dermatol. 1976 Oct;112(10):1468–1468. [PubMed]
  • Cahill KM, Mofty AM, Kawaguchi TP. Primary cutaneous aspergillosis. Arch Dermatol. 1967 Nov;96(5):545–547. [PubMed]
  • Patterson JE, Barden GE, Bia FJ. Hospital-acquired gangrenous mucormycosis. Yale J Biol Med. 1986 Jul-Aug;59(4):453–459. [PMC free article] [PubMed]
  • Carlile JR, Millet RE, Cho CT, Vats TS. Primary cutaneous aspergillosis in a leukemic child. Arch Dermatol. 1978 Jan;114(1):78–80. [PubMed]
  • Langlois RP, Flegel KM, Meakins JL, Morehouse DD, Robson HG, Guttmann RD. Cutaneous aspergillosis with fatal dissemination in a renal transplant recipient. Can Med Assoc J. 1980 Mar 22;122(6):673–676. [PMC free article] [PubMed]
  • Estes SA, Hendricks AA, Merz WG, Prystowsky SD. Primary cutaneous aspergillosis. J Am Acad Dermatol. 1980 Oct;3(4):397–400. [PubMed]
  • Allo MD, Miller J, Townsend T, Tan C. Primary cutaneous aspergillosis associated with Hickman intravenous catheters. N Engl J Med. 1987 Oct 29;317(18):1105–1108. [PubMed]
  • Grossman ME, Fithian EC, Behrens C, Bissinger J, Fracaro M, Neu HC. Primary cutaneous aspergillosis in six leukemic children. J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):313–318. [PubMed]
  • Nash G, Foley FD, Goodwin MN, Jr, Bruck HM, Greenwald KA, Pruitt BA., Jr Fungal burn wound infection. JAMA. 1971 Mar 8;215(10):1664–1666. [PubMed]
  • Bruck HM, Nash G, Stein JM, Lindberg RB. Studies on the occurrence and significance of yeasts and fungi in the burn wound. Ann Surg. 1972 Jul;176(1):108–110. [PubMed]
  • Salisbury RE, Silverstein P, Goodwin MN., Jr Upper extremity fungal invasions secondary to large burns. Plast Reconstr Surg. 1974 Dec;54(6):654–659. [PubMed]
  • Bruck HM, Nash G, Foley D, Pruitt BA., Jr Opportunistic fungal infection of the burn wound with phycomycetes and Aspergillus. A clinical-pathologic review. Arch Surg. 1971 May;102(5):476–482. [PubMed]
  • Panke TW, McManus AT, Jr, McLeod CG., Jr "Fruiting bodies" of aspergillus on the skin of a burned patient. Am J Clin Pathol. 1978 Feb;69(2):188–189. [PubMed]
  • Stone HH, Cuzzell JZ, Kolb LD, Moskowitz MS, McGowan JE., Jr Aspergillus infection of the burn wound. J Trauma. 1979 Oct;19(10):765–767. [PubMed]

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