Search tips
Search criteria 


Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. Apr 1991; 59(4): 1465–1469.
PMCID: PMC257864
Induction of antibody response to Chlamydia trachomatis in the genital tract by oral immunization.
Z D Cui, D Tristram, L J LaScolea, T Kwiatkowski, Jr, S Kopti, and P L Ogra
Department of Pediatrics, State University of New York, Children's Hospital of Buffalo 14222.
Groups of BALB/c mice were orally immunized with Chlamydia trachomatis serovar L2/434/Bu in order to characterize the nature and kinetics of the chlamydial antibody response in the cervix and other mucosal sites. These animals were subsequently challenged intravaginally to determine whether oral immunization offers protection against chlamydial antigen shedding in the genital tract. Following oral immunization, immunoglobulin A antibody activity was detected in the genital tract as well as other mucosal sites. Subsequent intravaginal challenges exhibited booster effects on preexisting antibody activity in the genital tract. Significant protection against challenge infection in the genital tract was observed by oral immunization. This was indicated by the absence of any chlamydial antigen shedding in cervical secretions. On the other hand, passively administered chlamydial-specific serum immunoglobulin G antibody did not significantly influence the course of cervical shedding of the organism and did not confer any protection against a subsequent intravaginal challenge. It is concluded that prior oral immunization can induce a secretory antibody response in the genital tract and provide protection against subsequent infection.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (827K), or click on a page image below to browse page by page.
Articles from Infection and Immunity are provided here courtesy of
American Society for Microbiology (ASM)