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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Am J Psychiatry. Author manuscript; available in PMC 2008 October 7.
Published in final edited form as:
PMCID: PMC2562873

Computer-Assisted Delivery of Cognitive-Behavioral Therapy for Addiction: A Randomized Trial of CBT4CBT



To evaluate the efficacy of a computer-based version of cognitive behavioral therapy (CBT) for substance dependence.


This was a randomized clinical trial in which 77 individuals seeking treatment for substance dependence at an outpatient community setting were randomized to standard treatment or standard treatment with biweekly access to computer-based training in CBT (CBT4CBT).


Treatment retention and data availability were comparable across the treatment conditions. Participants assigned to the CBT4CBT condition submitted significantly more urine specimens that were negative for any type of drugs and tended to have longer continuous periods of abstinence during treatment. The CBT4CBT program was positively evaluated by participants. In the CBT4CBT condition, outcome was more strongly associated with treatment engagement than in TAU; further, completion of homework assignments in CBT4CBT was significantly correlated with outcome and a significant predictor of treatment involvement.


These data suggest that CBT4CBT is an effective adjunct to standard outpatient treatment for substance dependence and may provide an important means of making CBT, an empirically validated treatment, more broadly available.

Keywords: Behavior Therapy, Cognitive Therapy, Psychoactive Substance Use Disorder, Computers


Cognitive-behavioral therapy (CBT) has a comparatively strong level of empirical support across a range of psychiatric disorders (1-3), including substance use disorders (1, 4, 5). Despite evidence of positive and durable outcome (6, 7), CBT remains rarely implemented in the range of settings where individuals with substance use disorders are treated (8). There are a number of obstacles to delivering CBT and other empirically validated therapies in clinical practice, including the limited availability of professional and specialty training programs that provide high quality training, supervision and certification in CBT (9), high rates of clinician turnover and lack of a CBT-trained workforce in many treatment settings (10-12), the relative complexity and cost of training clinicians in CBT (13, 14), as well as high case loads and limited resources. Available evidence suggests that while many clinicians report using CBT they tend to overestimate their use of this and other empirically supported therapies (15).

Hence, computer-assisted delivery of CBT, if demonstrated to be feasible and effective, could play an important role in broadening its availability and improving the quality of addiction treatment. Computer-assisted therapy could provide a comparatively low-cost means of teaching CBT skills to more substance users and allow clinicians to focus on acute concerns and problems of the individuals with whom they work. Moreover, by standardizing treatment delivery, computer-assisted training could also provide more consistent, and perhaps more effective, teaching and demonstration of CBT than is available in some settings, through its capacity to convey information via a range of media (text, video, audio instruction, interactive exercises). The ability to select or tailor content to address the needs of particular individuals allows for choice of different topics, control over the speed of presentation of information, and repetition of modules when necessary. These flexible parameters may especially important for substance abusers, many of whom experience significant cognitive impairment, including memory and concentration problems, particularly in the early stages of treatment (16, 17).

In the treatment of depression and anxiety disorders, computer-assisted delivery of CBT has been demonstrated in randomized trials to be both effective (18-25) and cost effective (26). However, there have been few evaluations of computer-assisted treatment, of any type, for the addictions. Much of this work has been done in the area of smoking, where several randomized trials of predominantly cognitive-behavioral interventions or self-help guidelines delivered via computers/internet have indicated positive effects on quit rates or attempts (27-29). Computer-assisted brief motivational approaches and self-control training programs have shown promise in randomized controlled trials with problem drinkers (30, 31) and college students (32). A computer-based HIV/AIDS education program was more effective than counselor-provided education in helping injection drug users learn and retain information about HIV, although both approaches were comparable in reducing HIV risk behaviors (33).

In this report, we describe main outcome findings from a randomized clinical trial of a six-module computer-based training for cognitive behavioral therapy (‘CBT4CBT’), wherein individuals entering a community-based clinic were randomized to standard treatment (treatment as usual, TAU) or TAU plus CBT4CBT over a period of 8 weeks. Given the established efficacy of CBT across a range of addictions and the unavailability of empirically validated therapies in many community based settings, CBT4CBT was evaluated in terms of one model of how it might be used in clinical practice, that is, as a stand-alone addition to regular clinical practice and delivered to a heterogeneous group of individuals seeking treatment for addiction. The primary hypothesis was that individuals assigned to CBT4CBT would reduce their frequency of substance use and submit fewer positive urine toxicology screens than those randomized to TAU. Given data from previous CBT trials linking compliance, homework completion and outcome (34-36), a secondary hypothesis was that treatment engagement, including homework completion, in the CBT4CBT program would be more strongly linked to positive substance use outcomes than in TAU.



Participants were recruited from individuals seeking treatment at Liberation Program's Mill Hill clinic, a community based outpatient substance abuse treatment provider in Bridgeport, CT. Participants were English-speaking adults who met DSM-IV criteria for any current substance dependence disorder, including alcohol, cocaine, opioids, or marijuana. Exclusion criteria were minimal to facilitate recruitment of a clinically representative group of individuals seeking treatment in a community setting. Thus, individuals were excluded only if (1) they had not used alcohol or illegal drugs within the past 28 days or failed to meet DSM-IV criteria for a current substance dependence disorder, (2) had an untreated psychotic disorder which precluded outpatient treatment, or (3) were unlikely to be able to complete 8 weeks of outpatient treatment due to a planned move or pending court case from which incarceration was likely to be imminent.

As shown in the participant flow diagram (Figure 1), 77 of the 155 individuals screened were determined to be eligible for the study, provided written informed consent and were randomized. Following a complete description of the study and provision of written informed consent approved by the Yale University School of Medicine Human Investigations Committee, participants were randomized to either TAU or CBT4CBT, using a computerized urn randomization program (37) to balance treatment groups with respect to primary substance used, gender and ethnicity.

Figure 1
CONSORT diagram: Flow of participants through the protocol


All participants were offered standard treatment at the clinic, which consisted of weekly individual and group sessions of general drug counseling. All participants also met twice weekly with an independent clinical evaluator who collected urine and breath specimens, assessed recent substance use and monitored other clinical symptoms. Those randomized to the CBT4CBT condition were provided access to the computer program in a small private room within the clinic. A research associate guided participants through their initial use of the CBT4CBT program and was available to answer questions and assist participants each time they used the program. Participants accessed the program through an ID/password system to protect confidentiality.

The CBT4CBT program was intended to be user-friendly, requiring no previous experience with computers and minimal use of text-based material. The multimedia style of the program was based on elementary-level computer learning games, and presentation of material was done in a range of formats including graphic illustrations, videotaped examples, verbal instructions and audio voice-overs, interactive assessments and practice exercises.

The program consisted of six lessons, or modules, the content of which was based closely on a NIDA-published CBT manual (38) used in several previous randomized controlled trials in a range of substance-using populations (6, 39, 40). The modules covered the following core concepts: (1) understanding and changing patterns of substance use, (2) coping with craving, (3) refusing offers of drugs and alcohol, (4) problem-solving skills, (5) identifying and changing thoughts about drugs and alcohol, and (6) improving decision-making skills. The first module provided a brief explanation of how to use and navigate the program; following completion of the first module, participants could choose to access the modules in any order they preferred and repeat any section or module as many times as they wished.

Each module in the CBT4CBT program was structured as follows: First, the key concept for each module was introduced through a brief ‘movie’ using actors and realistic settings depicting situations in which an individual was offered drugs or had to cope with a challenging situation in which substance use was likely. Next, after the narrator explained the key skill covered in that module with graphics and voice-overs, the ‘movie’ was repeated, this time with a different ending as the same characters applied the skills to change the outcome of the situation so as to avoid substance use (e.g. emphasis was on how individuals could use the CBT skills to ‘change their story’). Additional videotaped vignettes were used to reinforce the skills taught (e.g., in the ‘refusal skills’ module, the user could click buttons to see additional examples of the characters demonstrating assertive versus aggressive versus passive responding). Next, each module include an interactive assessment followed by a short vignette with an actor explaining how use of each skill had helped him/her avoid substance use and how each CBT principle could be applied to other problems; the intention of this section was to address common areas of resistance in CBT (“Why should I do homework?”) and to emphasize how CBT skills could be generalized beyond substance use issues. Finally, each module concluded with the narrator providing a review of the key points covered, followed by the characters demonstrating how they would complete the ‘homework’ or practice assignment for that module based on the situation depicted in the movie. Participants were then given an identical practice assignment and reminder sheet to take with them.

This general sequence of activities was intended to be similar to the CBT manual's (38) therapist guidelines for structuring sessions (introduction of the skill topic, didactic instruction, practice via modeling and role-plays, assessment of the patient's understanding of the material, and assignment of homework). However, this sequence also capitalized on the unique advantages of multimedia computer-assisted instruction, including presentation of information in a range of media formats. Each module was intended to require about 45 minutes to complete, depending on the speed with which the user navigated the program and the amount of material he or she selected to access or repeat.


Participants were assessed before treatment, twice weekly during treatment, and at the 8-week treatment termination point by an independent clinical evaluator. Participants were administered the Structured Clinical Interview for DSM-IV (SCID)(41) prior to randomization to establish substance use and psychiatric diagnoses. The Substance Abuse Calendar, similar to the Timeline Follow Back (42, 43), was administered weekly during treatment to collect detailed day-by-day self-reports of drug and alcohol use throughout the 56-day treatment period as well as for the 28-day period prior to randomization.

Participant self-reports of illegal drug use were verified through urine toxicology screens that were obtained at every assessment visit. Of 578 urine specimens collected during the treatment phase of the study (between days 4 and 56), the majority were consistent with participant self report in that only 58 (10%) were positive for drugs in cases where the participant had denied recent use during the period the drug's metabolites are typically detectable in urine (3 days for cocaine and opioids, 7 for marijuana). Using these cutoffs, 23 urines were submitted that were positive for cocaine when the participant had denied cocaine use in the past 3 days, 31 were positive for marijuana when the participant had denied marijuana use in the past 7 days, and 9 were positive for opioids when the participant had denied opioid use in the past 3 days. This rate is consistent with previous studies of substance-dependent samples (43-45). Breathalyzer samples were also collected at each assessment visit; none indicated recent alcohol use.

Data analyses

The a priori primary outcome measures were results of urine toxicology screens (operationalized as the number of drug-positive urine samples collected during treatment) and frequency of substance use (operationalized as the percentage of days in the 56-day treatment period the participant reported using alcohol or any illegal drug). Secondary outcomes included the longest period of abstinence attained during treatment as well as retention in treatment. The principal data analytic strategy was analysis of variance for the two primary outcome variables for the 77 participants who were randomized to treatment (intention to treat) and the 73 participants who initiated treatment (treatment-exposed). Four participants who were randomized but did not initiate treatment had been assigned to CBT4CBT; of these, 3 were arrested after randomization but prior to the onset of treatment Results were highly consistent across analysis samples and therefore results from the treatment-exposed sample are presented below (the four individuals who dropped out immediately after randomization were not exposed to any protocol treatment, could not be located for any further assessments, and therefore contributed minimally to the dataset as no urine or self-report data were available).


Sample description

Table 1 presents baseline demographic characteristics and substance use and psychiatric diagnoses of the 73 participants who initiated treatment. Of these, 43% were female, 46% identified themselves as African American, 34% as European-American, 12% as Hispanic, and 6% as Native American. Most were single or divorced, 77% were unemployed, and 75% had completed high school. Over one third (37%) of the sample reported they were on probation or parole, and 27% indicated their application for treatment had been prompted by the criminal justice system.

Table 1
Baseline demographic variables and substance use by treatment condition

Most participants (59%) reported cocaine use as their primary substance use problem, followed by alcohol (18%), opioids (16%) and marijuana (7%), with multiple types of concurrent substance use common (79.5% were users of more than one type of drug or users of both alcohol and drugs). The participants reported they had been using their primary substance for a mean of 17 years, and reported using their primary substance for an average of 10 of the past 28 days. ANOVA and chi-square analyses indicated no significant differences by treatment condition on any of the variables presented in Table 1.

Treatment implementation, retention and data availability by condition

Of the 73 individuals who initiated treatment, 48 (66%) completed the study (22 in CBT4CBT, 26 in TAU, NS). As shown in Table 2, levels of exposure to the standard counseling services offered in the program was also comparable in both groups, with those assigned to CBT4CBT completing a mean of 39 days and those assigned to TAU completing 41 days of the 56 day protocol. Hence, analyses of the primary substance use outcomes were not constrained by differential rates of attrition nor data availability.

Table 2
Retention and primary substance use outcomes by treatment condition

Of those who initiated the CBT4CBT program, the mean number of computer sessions completed was 4.3 (SD=2.4) of the 6 modules offered. Participants spent an average of 38.3 (SD= 8.2) minutes per session working with each module and tended to complete the modules in the order presented (e.g., 34/35 participants completed Module 1 (patterns of use and functional analysis), 25 completed Module 2 (coping with craving), 20 completed Module 3 (refusing offers), 19 completed Module 4 (problem solving), 18 completed Module 5 (addressing cognitions), and 15 completed Module 6 (decision making). As noted earlier, homework was assigned at the end of each module; participants completed an average of 2.9 homework assignments (SD=2.0). Twenty-six participants completed evaluation of the program where they were asked to rate their level of agreement with a range of statements about the CBT4CBT program using a Likert-type scale with ratings of 1 indicating low satisfaction and 5 indicating high satisfaction. For the 17 items evaluating various aspects of the program (e.g., “The directions were easy to understand”; “The program helped me think about my problems in a new way”), the mean satisfaction rating was 4.3 (SD=0.6).

Effects of treatment on primary substance use outcomes

Participants assigned to CBT4CBT submitted significantly fewer urine specimens that were positive for any type of drug use (2.2 versus 4.3, F=6.18, p=.02), with a moderate effect size (d=.59) and a lower proportion of urines that were positive for any drug (34 versus 53%, F=3.9, p=.05, d=.46). This was most marked for cocaine (28% versus 44% positive specimens). Duration of longest continuous (urine confirmed) period of abstinence during treatment was longer for those assigned to CBT4CBT than TAU (22 versus 17 days). Although this fell just short of statistical significance, the effect size was moderate (d=.45). The difference between groups for self-reported percent days of abstinence for all illicit drugs and alcohol was not statistically significant.

CBT4CBT program utilization and outcome

Consistent with previous support for links between pretreatment substance use severity (46), treatment retention (47), and outcome, we expected strong relationships between these variables and outcome among in this sample, but with treatment involvement more closely tied to outcome in the CBT4CBT condition than in TAU. Table 3 presents simple correlations of the relationships between baseline severity of substance use (frequency of substance use at baseline, years of substance use), treatment involvement (indicated by number of days retained in the treatment program, number of individual and group sessions attended, and homework completion), and treatment outcome (percent of drug-negative urine specimens, self-reported days abstinent, and duration of longest consecutive period of abstinence during treatment. In TAU, the indicators of baseline substance use severity tended to have higher correlations with outcome than the treatment retention indicators, while the reverse held for the CBT4CBT condition, where treatment involvement and completion of homework assignments had higher correlations. Results of structural equation modeling (48) were consistent with this interpretation, with a good fitting model indicating that treatment involvement (r= .77, CR=3.5, p<.001) and completion of homework (r=.85, CR=4.2, p<.001) were strongly related to outcome in CBT4CBT.

Table 3
Simple correlations of indicators of pretreatment substance use severity, treatment involvement and substance use outcome by treatment condition


In this randomized clinical trial of the efficacy of a computer-assisted CBT program for reducing drug use, participants using the CBT4CBT program submitted significantly fewer drug-positive urines specimens and tended to have longer periods of abstinence during treatment compared with standard TAU at a community based clinic. This is to our knowledge the first randomized clinical trial evaluating computer-assisted treatment for substance use disorders that reports on biologically-verified drug use outcomes. Thus, the study both adds to the existing positive literature on computer-assisted delivery of CBT for depression and anxiety disorders by extending it to a new and highly challenging population, but also provides strong evidence for the efficacy of computer-assisted training via use of data from urine toxicology screens, rather than self- or therapist report, both of which may be subject to bias. The CBT4CBT program was viewed by participants as highly engaging, was associated with promising outcomes, and potentially addresses a critical issue related to the availability of CBT in clinical practice.

Similarly, this trial is consistent with multiple trials suggesting practice of CBT skills outside of sessions via completion of homework assignments may be an important active ingredient of outcome CBT (34, 36) in that there was a significant positive relationship between number of CBT4CBT homework assignments completed and substance use outcomes. That is, indicators of treatment involvement was strongly related to outcome in the CBT4CBT condition, while in the TAU condition outcome was more strongly related to baseline severity of substance use than level of treatment engagement. Given the link between use of the program and outcome, more frequent access to and use of the CBT4CBT program (e.g., via the internet), should be evaluated as a strategy to enhance the potential benefits of this approach.

Strengths of this trial included randomization of a comparatively large and diverse group of participants in a community clinic, comparable levels of retention and data availability in both conditions, and reliance on independent, biological indicators of outcome. While not addressed in this study, the high level of control over the delivery of specific modules or treatment components (such as homework) in computer-assisted training may permit more refined study of the specific mediators of CBT via future clinical trials where these elements are systematically manipulated with greater precision than is typically possible in clinician-delivered therapies.

This study had several limitations as well. First, it should be noted that the study did not address whether computer assisted delivery of training was comparable or superior to clinician-delivered CBT, nor did it control for the additional time the participants spent working with the computer program in addition to the TAU received. Moreover, use of a TAU comparison condition which was not constrained or controlled had the typical disadvantages of this type of comparison (49), including variability in content and duration. On the other hand, it did constitute an active treatment comparison (50, 51) and therefore provided a rigorous control for evaluating any added benefit conferred by CBT4CBT. Second, in common with most trials involving substance users, attrition was an issue, as approximately 65% of those who initiated their protocol treatment completed it. On the other hand, data availability was comparable for both conditions and the retention rates are comparatively high given the unselected nature of the study population. Moreover, our extensive efforts to reach and collect data from those who dropped out of treatment (52) provided complete data for over 80% of the treatment exposed sample for the full 56 day study period. Third, it should be noted that the analyses evaluating the relationships between baseline substance use severity, treatment involvement, and outcome; are correlational and causality cannot be inferred.

Finally, because CBT has been demonstrated to be effective across several substance use disorders we decided to evaluate CBT4CBT with a heterogeneous sample of outpatients who used multiple substances concurrently. While this provided stronger evidence for the generalizability of the CBT4CBT program, it produced insufficient sample sizes for analyzing different subgroups of patients. In this regard, it should also be noted that our significant urine outcomes are complicated by the fact that some substances are detectable in urine for longer periods (marijuana) than others (cocaine). On the other hand, detecting a significant difference under these circumstances and in a heterogeneous community-based sample provided comparatively strong support for this promising new model. These results should be replicated before CBT4CBT is advocated for broader use in the substance abuse treatment system, and we are currently conducting a larger trial with a more homogeneous cocaine-dependent methadone-maintained sample.


Support was provided by NIDA grants R37-DA 015969 (KMC), K05-DA00457 (KMC), K05-DA00089 (BJR), and P50-DA09241. We gratefully acknowledge the support of the staff and leadership of Liberation Programs, Inc.


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