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Logo of behbrainBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBehavioral and Brain Functions : BBFJournal Front Page
Behav Brain Funct. 2008; 4: 40.
Published online Sep 17, 2008. doi:  10.1186/1744-9081-4-40
PMCID: PMC2553789
Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
Helena M Service,1 Mirka Hintsanen,1 Taina Hintsa,1 Terho Lehtimäki,2,3 Olli T Raitakari,4 Jorma S Viikari,5 and Liisa Keltikangas-Järvinencorresponding author1
1Department of Psychology, University of Helsinki, Finland
2Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland
3Medical School, University of Tampere, Finland
4Department of Clinical Physiology, University of Turku, Finland
5Department of Medicine, University of Turku, Finland
corresponding authorCorresponding author.
Helena M Service: helena.service/at/; Mirka Hintsanen: mirka.hintsanen/at/; Taina Hintsa: taina.hintsa/at/; Terho Lehtimäki: terho.lehtimaki/at/; Olli T Raitakari: olli.raitakari/at/; Jorma S Viikari: jorma.viikari/at/; Liisa Keltikangas-Järvinen: liisa.keltikangas-jarvinen/at/
Received March 31, 2008; Accepted September 17, 2008.
Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to be associated with Type A behavior.
The study examined whether Type A behavior pattern is associated with the single nucleotide polymorphism (SNP) SNP8NRG221533 of the NRG1. The subjects were 631 men and women participating in the population-based Cardiovascular Risk in Young Finns study in 1992 and 2001. Type A was self-assessed with the Framingham Type A Scale and reassessed nine years later.
Type A was associated with NRG1 genotype. Carriers of genotype CC scored lower on Type A compared to the others.
Our study has pinpointed a SNP in NRG1 that predicts Type A behavior. As previous evidence suggests an association for NRG1 with beta-adrenergic stimulation, its role underlying Type A is discussed.
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