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Logo of behbrainBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBehavioral and Brain Functions : BBFJournal Front Page
 
Behav Brain Funct. 2008; 4: 39.
Published online Aug 24, 2008. doi:  10.1186/1744-9081-4-39
PMCID: PMC2553416
An association study of ADSS gene polymorphisms with schizophrenia
Fuquan Zhang,1 Pak C Sham,2 Hua Fan,3 Yong Xu,1 Xuezhu Huang,1 Honcheong So,2 Yuqing Song,2 and Pozi Liucorresponding author1
1Institute of Neurological disorders, Tsinghua University; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Bejing, 100049, PR China
2Department of Psychiatry, University of Hong Kong, Hong Kong, PR China
3Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Bejing, PR China
corresponding authorCorresponding author.
Fuquan Zhang: zhfq/at/tsinghua.edu.cn; Pak C Sham: pcsham/at/hkucc.hku.hk; Hua Fan: iy4232925/at/163.com; Yong Xu: xuyongsmu/at/yahoo.com.cn; Xuezhu Huang: huangxuezhu/at/tsinghua.edu.cn; Honcheong So: hcso910/at/gmail.com; Yuqing Song: songyq293/at/hotmail.com; Pozi Liu: liupozi/at/tsinghua.edu.cn
Received April 20, 2008; Accepted August 24, 2008.
Abstract
Background
Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. It was suggested that the blood-derived RNA of ADSS was down-regulated in schizophrenia (SZ) and one of the eight putative biomarker genes to discriminate SZ from normal controls. However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not.
Methods
We attempted to examine the association of ADSS gene with schizophrenia in a Chinese population of 480 schizophrenics and 502 normal controls. Genotyping was performed by the Sequenom platform.
Results
The 6 marker SNPs (rs3102460, rs3127459, rs3127460, rs3127465, rs3006001, and rs3003211) were genotyped. The frequencies of alleles, genotypes, and haplotypes were tested between cases and controls. There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups.
Conclusion
Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population. Large sample size study is needed to validate or replicate our association study, especially from other ethnic populations.
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