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BMJ. 1995 February 25; 310(6978): 489–491.
PMCID: PMC2548871

Relation between maternal haemoglobin concentration and birth weight in different ethnic groups.

Abstract

OBJECTIVE--To assess the relation of the lowest haemoglobin concentration in pregnancy with birth weight and the rates of low birth weight and preterm delivery in different ethnic groups. DESIGN--Retrospective analysis of 153,602 pregnancies with ethnic group and birth weight recorded on a regional pregnancy database during 1988-91. The haemoglobin measurement used was the lowest recorded during pregnancy. SETTING--North West Thames region. SUBJECTS--115,262 white women, 22,206 Indo-Pakistanis, 4570 Afro-Caribbeans, 2642 mediterraneans, 3905 black Africans, 2351 orientals, and 2666 others. MAIN OUTCOME MEASURES--Birth weight and rates of low birth weight (< 2500 g) and preterm delivery (< 37 completed weeks). RESULTS--Maximum mean birth weight in white women was achieved with a lowest haemoglobin concentration in pregnancy of 85-95 g/l; the lowest incidence of low birth weight and preterm labour occurred with a lowest haemoglobin of 95-105 g/l. A similar pattern occurred in all ethnic groups. CONCLUSIONS--The magnitude of the fall in haemoglobin concentration in pregnancy is related to birth weight; failure of the haemoglobin concentration to fall below 105 g/l indicates an increased risk of low birth weight and preterm delivery. This phenomenon is seen in all ethnic groups. Some ethnic groups have higher rates of low birth weight and preterm delivery than white women, and they also have higher rates of low haemoglobin concentrations. This increased rate of "anaemia," however, does not account for their higher rates of low birth weight, which occurs at all haemoglobin concentrations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Taylor DJ, Lind T. Red cell mass during and after normal pregnancy. Br J Obstet Gynaecol. 1979 May;86(5):364–370. [PubMed]
  • Lu ZM, Goldenberg RL, Cliver SP, Cutter G, Blankson M. The relationship between maternal hematocrit and pregnancy outcome. Obstet Gynecol. 1991 Feb;77(2):190–194. [PubMed]
  • Godfrey KM, Redman CW, Barker DJ, Osmond C. The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Br J Obstet Gynaecol. 1991 Sep;98(9):886–891. [PubMed]
  • Horn E. Iron and folate supplements during pregnancy: supplementing everyone treats those at risk and is cost effective. BMJ. 1988 Nov 19;297(6659):1325–1327. [PMC free article] [PubMed]
  • Klebanoff MA, Shiono PH, Selby JV, Trachtenberg AI, Graubard BI. Anemia and spontaneous preterm birth. Am J Obstet Gynecol. 1991 Jan;164(1 Pt 1):59–63. [PubMed]
  • HYTTEN FE, PAINTIN DB. Increase in plasma volume during normal pregnancy. J Obstet Gynaecol Br Emp. 1963 Jun;70:402–407. [PubMed]
  • Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet. 1986 May 3;1(8488):992–995. [PubMed]
  • Dunlop W, Furness C, Hill LM. Maternal haemoglobin concentration, haematocrit and renal handling of urate in pregnancies ending in the births of small-for-dates infants. Br J Obstet Gynaecol. 1978 Dec;85(12):938–940. [PubMed]
  • Sagen N, Nilsen ST, Kim HC, Bergsjø P, Koller O. Maternal hemoglobin concentration is closely related to birth weight in normal pregnancies. Acta Obstet Gynecol Scand. 1984;63(3):245–248. [PubMed]
  • Mau G. Hemoglobin changes during pregnancy and growth disturbances in the neonate. J Perinat Med. 1977;5(4):172–177. [PubMed]
  • Koller O, Sagen N, Ulstein M, Vaula D. Fetal growth retardation associated with inadequate haemodilution in otherwise uncomplicated pregnancy. Acta Obstet Gynecol Scand. 1979;58(1):9–13. [PubMed]
  • Hibbard BM. Iron and folate supplements during pregnancy: supplementation is valuable only in selected patients. BMJ. 1988 Nov 19;297(6659):1324–1326. [PMC free article] [PubMed]
  • Fenton V, Cavill I, Fisher J. Iron stores in pregnancy. Br J Haematol. 1977 Sep;37(1):145–149. [PubMed]

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