Search tips
Search criteria 


Logo of jvirolPermissionsJournals.ASM.orgJournalJV ArticleJournal InfoAuthorsReviewers
J Virol. 1985 May; 54(2): 304–310.
PMCID: PMC254798

Induction of angiosarcoma by a c-erbB transducing virus.


Recently, 12 new transductions of c-erbB have been identified in a series of Rous-associated virus type 1-induced erythroleukemias. During the passage of these new transducing viruses it has become apparent that the erythroleukemia in chicken 5005 contained two different c-erbB transducing viruses. One induces erythroblastosis, whereas the second induces angiosarcoma. The angiosarcoma- and erythroblastosis-inducing viruses appear to have had a common ancestor, since tumors induced by each contain a novel, 4.3-kilobase c-erbB-related EcoRI fragment. The angiosarcoma-inducing virus has been named avian angiosarcoma virus and is designated for the chicken in which it originated.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.4M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 1984 Feb 9;307(5951):521–527. [PubMed]
  • Frykberg L, Palmieri S, Beug H, Graf T, Hayman MJ, Vennström B. Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes. Cell. 1983 Jan;32(1):227–238. [PubMed]
  • Gazzolo L, Moscovici C, Moscovici MG, Samarut J. Response of hemopoietic cells to avian acute leukemia viruses: effects on the differentiation of the target cells. Cell. 1979 Mar;16(3):627–638. [PubMed]
  • Graf T, Fink D, Beug H, Royer-Pokora B. Oncornavirus-induced sarcoma formation obscured by rapid development of lethal leukemia. Cancer Res. 1977 Jan;37(1):59–63. [PubMed]
  • Graf T, Royer-Pokora B, Schubert GE, Beug H. Evidence for the multiple oncogenic potential of cloned leukemia virus: in vitro and in vitro studies with avian erythroblastosis virus. Virology. 1976 Jun;71(2):423–433. [PubMed]
  • Graf T, von Kirchbach A, Beug H. Characterization of the hematopoietic target cells of AEV, MC29 and AMV avian leukemia viruses. Exp Cell Res. 1981 Feb;131(2):331–343. [PubMed]
  • Hayman MJ, Beug H. Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface. Nature. 309(5967):460–462. [PubMed]
  • Hayman MJ, Ramsay GM, Savin K, Kitchener G, Graf T, Beug H. Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein. Cell. 1983 Feb;32(2):579–588. [PubMed]
  • Hihara H, Yamamoto H, Shimohira H, Arai K, Shimizu T. Avian erythroblastosis virus isolated from chick erythroblastosis induced by lymphatic leukemia virus subgroup A. J Natl Cancer Inst. 1983 May;70(5):891–897. [PubMed]
  • Hughes SH, Shank PR, Spector DH, Kung HJ, Bishop JM, Varmus HE, Vogt PK, Breitman ML. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell. 1978 Dec;15(4):1397–1410. [PubMed]
  • Jaffe EA. Endothelial cells and the biology of factor VIII. N Engl J Med. 1977 Feb 17;296(7):377–383. [PubMed]
  • Miles BD, Robinson HL. High-frequency transduction of c-erbB in avian leukosis virus-induced erythroblastosis. J Virol. 1985 May;54(2):295–303. [PMC free article] [PubMed]
  • Nishida T, Sakamoto S, Yamamoto T, Hayman M, Kawai S, Toyoshima K. Comparison of genome structures among three different strains of avian erythroblastosis virus. Gan. 1984 Apr;75(4):325–333. [PubMed]
  • Privalsky ML, Bishop JM. Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb-B polypeptide. Proc Natl Acad Sci U S A. 1982 Jul;79(13):3958–3962. [PubMed]
  • Privalsky ML, Ralston R, Bishop JM. The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases. Proc Natl Acad Sci U S A. 1984 Feb;81(3):704–707. [PubMed]
  • Privalsky ML, Sealy L, Bishop JM, McGrath JP, Levinson AD. The product of the avian erythroblastosis virus erbB locus is a glycoprotein. Cell. 1983 Apr;32(4):1257–1267. [PubMed]
  • Sealy L, Privalsky ML, Moscovici G, Moscovici C, Bishop JM. Site-specific mutagenesis of avian erythroblastosis virus: erb-B is required for oncogenicity. Virology. 1983 Oct 15;130(1):155–178. [PubMed]
  • Sergeant A, Saule S, Leprince D, Begue A, Rommens C, Stehelin D. Molecular cloning and characterization of the chicken DNA locus related to the oncogene erbB of avian erythroblastosis virus. EMBO J. 1982;1(2):237–242. [PubMed]
  • Taylor JF, Templeton AC, Vogel CL, Ziegler JL, Kyalwazi SK. Kaposi's sarcoma in Uganda: a clinico-pathological study. Int J Cancer. 1971 Jul 15;8(1):122–135. [PubMed]
  • Vennström B, Bishop JM. Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell. 1982 Jan;28(1):135–143. [PubMed]
  • Vennström B, Fanshier L, Moscovici C, Bishop JM. Molecular cloning of the avian erythroblastosis virus genome and recovery of oncogenic virus by transfection of chicken cells. J Virol. 1980 Nov;36(2):575–585. [PMC free article] [PubMed]
  • Yamamoto T, Hihara H, Nishida T, Kawai S, Toyoshima K. A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas. Cell. 1983 Aug;34(1):225–232. [PubMed]
  • Yamamoto T, Nishida T, Miyajima N, Kawai S, Ooi T, Toyoshima K. The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell. 1983 Nov;35(1):71–78. [PubMed]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)