PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jvirolPermissionsJournals.ASM.orgJournalJV ArticleJournal InfoAuthorsReviewers
 
J Virol. Nov 1984; 52(2): 683–686.
PMCID: PMC254574
Experimental infection of rhesus monkeys with type D retrovirus.
N L Letvin, M D Daniel, P K Sehgal, L V Chalifoux, N W King, R D Hunt, W R Aldrich, K Holley, D K Schmidt, and R C Desrosiers
Abstract
The naturally occurring immunodeficiency syndrome of macaque monkeys is an important animal model for the acquired immunodeficiency syndrome in humans. A new type D retrovirus, distinct from Mason-Pfizer monkey virus, has been isolated from affected animals at the New England Regional Primate Research Center. We now report the results of experimental infection of macaques with retrovirus D/New England after 13 months of study. Inoculated macaques developed lymphadenopathy without follicular hyperplasia, profound neutropenia, and a transient decrease in peripheral blood lymphocyte blastogenic responsiveness. Despite our varying the strain of virus, the manner in which the virus was grown, the size of the inoculum, and the age of the inoculated animals, infected macaques have not developed opportunistic infections or profound, prolonged loss of T cell function, key features of the macaque immunodeficiency syndrome. Therefore, experimental infection of naive macaques with D/New England has not reproduced the naturally occurring macaque immunodeficiency syndrome.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (695K), or click on a page image below to browse page by page.
Articles from Journal of Virology are provided here courtesy of
American Society for Microbiology (ASM)