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Br Med J (Clin Res Ed). 1988 February 27; 296(6622): 612–614.
PMCID: PMC2545243

Duration of effectiveness of pertussis vaccine: evidence from a 10 year community study


A 10 year study of whooping cough in a discrete general practice community was performed to assess longitudinally the efficacy of pertussis vaccine from one to seven years after immunisation. Of the 436 cases of whooping cough over 10 years, 326 occurred in children aged 1-7 years. The rate of immunisation was known for each cohort of children born during each year, and the attack rate of whooping cough was thus calculated for those immunised and unimmunised. The attack rates were highest in those cohorts exposed to the epidemics of 1977-9, 1981-3, and 1985-7. The efficacy of the vaccine was calculated as a percentage as (attack rate in unimmunised group—attack rate in immunised group) × 100/attack rate in unimmunised group. It fell from 100% in the first year to 46% in the seventh, being 84% in the fourth and only 52% in the fifth.

Thus the pertussis vaccine or its schedule of use does not seem to provide sufficient herd immunity to prevent outbreaks of whooping cough. Matters might be improved if vaccination against pertussis were included in the preschool immunisation programme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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  • Church MA. Evidence of whooping-cough-vaccine efficacy from the 1978 whooping-cough epidemic in Hertfordshire. Lancet. 1979 Jul 28;2(8135):188–190. [PubMed]
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  • Jenkinson D, Pepper JD. A search for subclinical infection during a small outbreak of whooping cough: implications for clinical diagnosis. J R Coll Gen Pract. 1986 Dec;36(293):547–548. [PMC free article] [PubMed]

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