We thank the study participants who make this research possible. Layla Kassem and Jo Steele provided technical assistance; Michael O'Donovan and Paul Boyce gave advice on the pooling methods; Husseini Manji provided helpful comments on the manuscript; and the Rutgers University Cell & DNA Repository managed DNA samples.
Data and biomaterials for the NIMH sample were collected as part of 10 projects that participated in the NIMH Bipolar Disorder Genetics Initiative. From 1991-98, the Principal Investigators and Co-Investigators were: Indiana Univ., Indianapolis, IN, U01 MH46282, John Nurnberger, MD , PhD, Marvin Miller, MD , and Elizabeth Bowman, MD ; Washington Univ., St. Louis, MO, U01 MH46280, Theodore Reich, MD , Allison Goate, PhD, and John Rice, PhD; Johns Hopkins Univ., Baltimore, MD U01 MH46274, J. Raymond DePaulo, Jr MD Sylvia Simpson, MD , MPH, and Colin Stine, PhD; NIMH Intramural Research Program, Clinical Neurogenetics Branch, Bethesda, MD, Elliot Gershon, MD , Diane Kazuba, BA, and Elizabeth Maxwell, M.S.W. From 1999-03, the Principal Investigators and Co-Investigators were: Indiana Univ., Indianapolis, IN, R01 MH59545, John Nurnberger, MD , PhD, Marvin J. Miller, MD , Elizabeth S. Bowman, MD , N. Leela Rau, MD , P. Ryan Moe, MD , Nalini Samavedy, MD , Rif El-Mallakh, MD (at Univ. of Louisville), Husseini Manji, MD (at Wayne State Univ.), Debra A. Glitz, MD (at Wayne State Univ.), Eric T. Meyer, M.S., Carrie Smiley, RN, Tatiana Foroud, PhD, Leah Flury, M.S., Danielle M. Dick, PhD, Howard Edenberg, PhD; Washington Univ., St. Louis, MO, R01 MH059534, John Rice, Ph.D,Theodore Reich, MD , Allison Goate, PhD, Laura Bierut, MD ; Johns Hopkins Univ., Baltimore, MD, R01 MH59533, Melvin McInnis MD , J. Raymond DePaulo, Jr MD Dean F. MacKinnon, MD , Francis M. Mondimore, MD , James B. Potash, MD , Peter P. Zandi, Ph.D, Dimitrios Avramopoulos, and Jennifer Payne; Univ. of Pennsylvania, PA, R01 MH59553, Wade Berrettini MD ,PhD ; Univ. of California at Irvine, CA, R01 MH60068, William Byerley MD , and Mark Vawter MD ; Univ. of Iowa, IA, R01 MH059548, William Coryell MD , and Raymond Crowe MD ; Univ. of Chicago, IL, R01 MH59535, Elliot Gershon, MD , Judith Badner PhD , Francis McMahon MD , Chunyu Liu PhD, Alan Sanders MD , Maria Caserta, Steven Dinwiddie MD , Tu Nguyen, Donna Harakal; Univ. of California at San Diego, CA, R01 MH59567, John Kelsoe, MD , Rebecca McKinney, BA; Rush Univ., IL, R01 MH059556, William Scheftner MD , Howard M. Kravitz, D.O., MPH, Diana Marta, BA, Annette Vaughn-Brown, MSN, RN, and Laurie Bederow, MA; NIMH Intramural Research Program, Bethesda, MD, 1Z01MH002810-01, Francis J. McMahon, MD , Layla Kassem, PsyD, Sevilla Detera-Wadleigh, Ph.D, Lisa Austin, Ph.D, Dennis L. Murphy, MD.
The NIMH control subjects were collected by the NIMH Schizophrenia Genetics Initiative “Molecular Genetics of Schizophrenia II” (MGS-2) collaboration. The investigators and coinvestigators are: ENH/Northwestern Univ., Evanston, IL, MH059571, Pablo V. Gejman, MD (Collaboration Coordinator; PI), Alan R. Sanders, MD ; Emory Univ. School of Medicine, Atlanta, GA,MH59587, Farooq Amin, MD (PI); Louisiana State Univ. Health Sciences Center; New Orleans, Louisiana, MH067257, Nancy Buccola APRN, BC, MSN (PI); Univ. of California-Irvine, Irvine, CA,MH60870, William Byerley, MD (PI); Washington Univ., St. Louis, MO, U01, MH060879, C. Robert Cloninger, MD (PI); Univ. of Iowa, Iowa, IA,MH59566, Raymond Crowe, MD (PI), Donald Black, MD ; Univ. of Colorado, Denver, CO, MH059565, Robert Freedman, MD (PI); Univ. of Pennsylvania, Philadelphia, PA, MH061675, Douglas Levinson MD (PI); Univ. of Queensland, Queensland, Australia, MH059588, Bryan Mowry, MD (PI); Mt. Sinai School of Medicine, New York, NY,MH59586, Jeremy Silverman, PhD (PI).
We thank the following clinician colleagues for help in collecting German patients: Margot Albus, Margitta Borrmann-Hassenbach, Ernst Franzek, Jürgen Fritze, Magdalena Gross, Thilo Held, Roland Kreiner, Mario Lanczik, Dirk Lichtermann,Wolfgang Maier, Jürgen Minges, Stephanie Ohlraun, Ulrike Reuner, Monja Tullius, Bettina Weigelt.
Supported by the NIMH Intramural Research Program, Deutsche Forschungsgemeinschaft, the National German Genome Research Network of the Federal Ministry of Education and Research, the National Alliance for Research on Schizophrenia and Depression, the Alfried Krupp von Bohlen und Halbach-Stiftung, and the National Institute on Aging. JS is supported by NIH grants R01GM60457 and R01CA098438.