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Anesth Prog. 1984 Mar-Apr; 31(2): 77–81.
PMCID: PMC2515536

Comparison of Conorphone, A Mixed Agonist-Antagonist Analgesic, to Codeine for Postoperative Dental Pain


The analgesic efficacy of two doses of conorphone (20 and 40 mg), a mixed agonist-antagonist analgesic, were compared to two doses of codeine for postoperative pain in the oral surgery model. Each subject received 2 of the 4 possible treatment at two separate sessions in an incomplete block, single crossover design. Both doses of conorphone and the 60 mg dose of codeine were superior to 30 mg of codeine for the various indices of analgesic activity. The 40 mg dose of conorphone resulted in a high incidence of side effects (25/30 subjects) such as drowsiness, dizziness, nausea and vomiting. The low dose of conorphone resulted in side effects similar to 60 mg of codeine with the exception of a greater incidence of drowsiness. These data suggest that while 40 mg of conorphone may not be well tolerated clinically, 20 mg of conorphone may be an alternative to 60 mg of codeine for postoperative pain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Cooper SA, Needle SE, Kruger GO. Comparative analgesic potency of aspirin and ibuprofen. J Oral Surg. 1977 Nov;35(11):898–903. [PubMed]
  • Forrest WH., Jr Orally administered zomepirac and parenterally administered morphine. Comparison for the treatment of postoperative pain. JAMA. 1980 Nov 21;244(20):2298–2302. [PubMed]
  • Dionne RA, Campbell RA, Cooper SA, Hall DL, Buckingham B. Suppression of postoperative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen, and acetaminophen plus codeine. J Clin Pharmacol. 1983 Jan;23(1):37–43. [PubMed]
  • Beaver WT, Feise GA. Twin crossover relative potency analgesic assays in man. I. Morphine vs. morphine. J Clin Pharmacol. 1977 Aug-Sep;17(8-9):461–479. [PubMed]
  • Cooper SA, Beaver WT. A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther. 1976 Aug;20(2):241–250. [PubMed]
  • Skjelbred P, Løkken P. Codeine added to paracetamol induced adverse effects but did not increase analgesia. Br J Clin Pharmacol. 1982 Oct;14(4):539–543. [PMC free article] [PubMed]
  • Cooper SA, Engel J, Ladov M, Precheur H, Rosenheck A, Rauch D. Analgesic efficacy of an ibuprofen-codeine combination. Pharmacotherapy. 1982 May-Jun;2(3):162–167. [PubMed]

Articles from Anesthesia Progress are provided here courtesy of American Dental Society of Anesthesiology