Search tips
Search criteria 


Logo of jvirolPermissionsJournals.ASM.orgJournalJV ArticleJournal InfoAuthorsReviewers
J Virol. 1991 November; 65(11): 6316–6319.
PMCID: PMC250343

Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8.


The host range of retroviruses is determined primarily by the presence of specific receptors on target cells which are recognized by the retroviral envelope glycoprotein. Somatic cell hybrids have been used to determine the chromosomal locations of several retroviral receptors in mice prior to their molecular cloning. Here we report that by using human-Chinese hamster somatic cell hybrids and a retroviral vector, we have mapped the receptor for the amphotropic murine leukemia virus to the pericentromeric region of human chromosome 8.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (679K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Albritton LM, Tseng L, Scadden D, Cunningham JM. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell. 1989 May 19;57(4):659–666. [PubMed]
  • Bill J, Palmer E, Jones C. Molecular cloning of MER-2, a human chromosome-11-encoded red blood cell antigen, using linkage of cotransfected markers. Somat Cell Mol Genet. 1987 Sep;13(5):553–561. [PubMed]
  • DeLarco J, Todaro GJ. Membrane receptors for murine leukemia viruses: characterization using the purified viral envelope glycoprotein, gp71. Cell. 1976 Jul;8(3):365–371. [PubMed]
  • Fisher JH, Emrie PA, Drabkin HA, Kushnik T, Gerber M, Hofmann T, Jones C. The gene encoding the hydrophobic surfactant protein SP-C is located on 8p and identifies an EcoRI RFLP. Am J Hum Genet. 1988 Oct;43(4):436–441. [PubMed]
  • Gazdar AF, Oie H, Lalley P, Moss WW, Minna JD. Identification of mouse chromosomes required for murine leukemia virus replication. Cell. 1977 Aug;11(4):949–956. [PubMed]
  • Hilkens J, van der Zeijst B, Buijs F, Kroezen V, Bleumink N, Hilgers J. Identification of a cellular receptor for mouse mammary tumor virus and mapping of its gene to chromosome 16. J Virol. 1983 Jan;45(1):140–147. [PMC free article] [PubMed]
  • Inui K, Kao FT, Fujibayashi S, Jones C, Morse HG, Law ML, Wenger DA. The gene coding for a sphingolipid activator protein, SAP-1, is on human chromosome 10. Hum Genet. 1985;69(3):197–200. [PubMed]
  • Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM. The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4399–4402. [PubMed]
  • Jones C, Kao FT, Taylor RT. Chromosomal assignment of the gene for folylpolyglutamate synthetase to human chromosome 9. Cytogenet Cell Genet. 1980;28(3):181–194. [PubMed]
  • Jones C, Morse HG, Kao FT, Carbone A, Palmer E. Human T-cell receptor alpha-chain genes: location on chromosome 14. Science. 1985 Apr 5;228(4695):83–85. [PubMed]
  • Kao FT, Puck TT. Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1275–1281. [PubMed]
  • Kozak CA. Genetic mapping of a mouse chromosomal locus required for mink cell focus-forming virus replication. J Virol. 1983 Oct;48(1):300–303. [PMC free article] [PubMed]
  • Kozak CA. Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1. J Virol. 1985 Sep;55(3):690–695. [PMC free article] [PubMed]
  • Kozak CA, Albritton LM, Cunningham J. Genetic mapping of a cloned sequence responsible for susceptibility to ecotropic murine leukemia viruses. J Virol. 1990 Jun;64(6):3119–3121. [PMC free article] [PubMed]
  • Kozak CA, Rowe WP. Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5. Science. 1979 Apr 6;204(4388):69–71. [PubMed]
  • Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M. Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2187–2189. [PubMed]
  • McBride OW, Kozak CA, Wilson SH. Mapping of the gene for DNA polymerase beta to mouse chromosome 8. Cytogenet Cell Genet. 1990;53(2-3):108–111. [PubMed]
  • Miller AD. Retrovirus packaging cells. Hum Gene Ther. 1990 Spring;1(1):5–14. [PubMed]
  • Miller AD, Buttimore C. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol. 1986 Aug;6(8):2895–2902. [PMC free article] [PubMed]
  • Miller AD, Garcia JV, von Suhr N, Lynch CM, Wilson C, Eiden MV. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J Virol. 1991 May;65(5):2220–2224. [PMC free article] [PubMed]
  • Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques. 1989 Oct;7(9):980–990. [PMC free article] [PubMed]
  • Nadeau JH. Maps of linkage and synteny homologies between mouse and man. Trends Genet. 1989 Mar;5(3):82–86. [PubMed]
  • Oie HK, Gazdar AF, Lalley PA, Russell EK, Minna JD, DeLarco J, Todaro GJ, Francke U. Mouse chromosome 5 codes for ecotropic murine leukaemia virus cell-surface receptor. Nature. 1978 Jul 6;274(5666):60–62. [PubMed]
  • O'Neill RR, Buckler CE, Theodore TS, Martin MA, Repaske R. Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus. J Virol. 1985 Jan;53(1):100–106. [PMC free article] [PubMed]
  • Ruddle NH, Conta BS, Leinwand L, Kozak C, Ruddle F, Besmer P, Baltimore D. Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5. J Exp Med. 1978 Aug 1;148(2):451–465. [PMC free article] [PubMed]
  • Sommerfelt MA, Williams BP, Clapham PR, Solomon E, Goodfellow PN, Weiss RA. Human T cell leukemia viruses use a receptor determined by human chromosome 17. Science. 1988 Dec 16;242(4885):1557–1559. [PubMed]
  • Sommerfelt MA, Williams BP, McKnight A, Goodfellow PN, Weiss RA. Localization of the receptor gene for type D simian retroviruses on human chromosome 19. J Virol. 1990 Dec;64(12):6214–6220. [PMC free article] [PubMed]
  • Testa JR, Parsa NZ, Le Beau MM, Vande Woude GF. Localization of the proto-oncogene MOS to 8q11-q12 by in situ chromosomal hybridization. Genomics. 1988 Jul;3(1):44–47. [PubMed]
  • Tsui LC, Farrall M, Donis-Keller H. Report of the committee on the genetic constitution of chromosomes 7 and 8. Cytogenet Cell Genet. 1989;51(1-4):166–201. [PubMed]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)