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Ann R Coll Surg Engl. 1989 March; 71(2): 97–100.
PMCID: PMC2498915

Preincisional intraparietal Augmentin in abdominal operations.


A total of 624 consecutive eligible patients undergoing abdominal operations received a single preoperative dose of amoxycillin/clavulanic acid (1.2 g Augmentin) for the prophylaxis of surgical wound infection. They were randomised to have the antibiotic injected intravenously at induction of anaesthesia (n = 328) or infiltrated subcutaneously along the line of the proposed incision (n = 296). The incidence of wound infections was considerably lower in the group given the antibiotic into the abdominal wall (8.4% compared with 15.9%--chi 2 = 7.90, P = 0.005). No significant differences were found in the incidence of other major or minor infective or non-infective postoperative complications between the groups. It is concluded that preincisional intraparietal injection is more effective than intravenous injection of Augmentin for the prophylaxis of surgical wound infection.

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Selected References

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  • Greenall MJ, Atkinson JE, Evans M, Pollock AV. Single dose antibiotic prophylaxis of surgical wound sepsis: which route of administration is best? A controlled clinical trial of intra-incisional against intravenous cephaloridine. J Antimicrob Chemother. 1981 Mar;7(3):223–227. [PubMed]
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  • Taylor TV, Dawson DL, de Silva M, Shaw SJ, Durrans D, Makin D. Preoperative intraincisional cefamandole reduces wound infection and postoperative inpatient stay in upper abdominal surgery. Ann R Coll Surg Engl. 1985 Jul;67(4):235–237. [PMC free article] [PubMed]
  • Drumm J, Donovan IA, Wise R, Lowe P. Metronidazole and Augmentin in the prevention of sepsis after appendicectomy. Br J Surg. 1985 Jul;72(7):571–573. [PubMed]
  • Porteous C, Davidson PM, Rawluk D, Brown M, Scott R, Conn G, McClure A, Murray WR. Peri-incisional mezlocillin versus rectal-metronidazole for wound infection prophylaxis. J Hosp Infect. 1985 Dec;6(4):413–418. [PubMed]

Articles from Annals of The Royal College of Surgeons of England are provided here courtesy of The Royal College of Surgeons of England