PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of annrcseLink to Publisher's site
 
Ann R Coll Surg Engl. 1989 March; 71(2): 97–100.
PMCID: PMC2498915

Preincisional intraparietal Augmentin in abdominal operations.

Abstract

A total of 624 consecutive eligible patients undergoing abdominal operations received a single preoperative dose of amoxycillin/clavulanic acid (1.2 g Augmentin) for the prophylaxis of surgical wound infection. They were randomised to have the antibiotic injected intravenously at induction of anaesthesia (n = 328) or infiltrated subcutaneously along the line of the proposed incision (n = 296). The incidence of wound infections was considerably lower in the group given the antibiotic into the abdominal wall (8.4% compared with 15.9%--chi 2 = 7.90, P = 0.005). No significant differences were found in the incidence of other major or minor infective or non-infective postoperative complications between the groups. It is concluded that preincisional intraparietal injection is more effective than intravenous injection of Augmentin for the prophylaxis of surgical wound infection.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (736K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Greenall MJ, Atkinson JE, Evans M, Pollock AV. Single dose antibiotic prophylaxis of surgical wound sepsis: which route of administration is best? A controlled clinical trial of intra-incisional against intravenous cephaloridine. J Antimicrob Chemother. 1981 Mar;7(3):223–227. [PubMed]
  • Taylor TV, Walker WS, Mason RC, Richmond J, Lee D. Preoperative intraparietal (intra-incisional) cefoxitin in abdominal surgery. Br J Surg. 1982 Aug;69(8):461–462. [PubMed]
  • Armstrong CP, Taylor TV, Reeves DS. Pre-incisional intraparietal injection of cephamandole: a new approach to wound infection prophylaxis. Br J Surg. 1982 Aug;69(8):459–460. [PubMed]
  • Playforth MJ, Smith GM, Evans M, Pollock AV. Pre-operative assessment of fitness score. Br J Surg. 1987 Oct;74(10):890–892. [PubMed]
  • Dixon JM, Armstrong CP, Duffy SW, Chetty U, Davies GC. A randomized prospective trial comparing the value of intravenous and preincisional cefamandole in reducing postoperative sepsis after operations upon the gastrointestinal tract. Surg Gynecol Obstet. 1984 Apr;158(4):303–307. [PubMed]
  • Taylor TV, Dawson DL, de Silva M, Shaw SJ, Durrans D, Makin D. Preoperative intraincisional cefamandole reduces wound infection and postoperative inpatient stay in upper abdominal surgery. Ann R Coll Surg Engl. 1985 Jul;67(4):235–237. [PMC free article] [PubMed]
  • Drumm J, Donovan IA, Wise R, Lowe P. Metronidazole and Augmentin in the prevention of sepsis after appendicectomy. Br J Surg. 1985 Jul;72(7):571–573. [PubMed]
  • Porteous C, Davidson PM, Rawluk D, Brown M, Scott R, Conn G, McClure A, Murray WR. Peri-incisional mezlocillin versus rectal-metronidazole for wound infection prophylaxis. J Hosp Infect. 1985 Dec;6(4):413–418. [PubMed]

Articles from Annals of The Royal College of Surgeons of England are provided here courtesy of The Royal College of Surgeons of England