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J Bacteriol. Feb 1969; 97(2): 848–860.
PMCID: PMC249769
Chromosome Replication in Salmonella typhimurium1
Hilary Chan and Karl G. Lark
aDivision of Biology, Kansas State University, Manhattan, Kansas 60502
1 This research has been submitted by Hilary Chan as part of a thesis in fulfillment of the requirements for the Ph.D. degree.
The replication of the Salmonella typhimurium chromosome was studied. As with E. coli 15T, replication was sequential. After amino acid starvation, replication proceeded from a unique and heritable region of the chromosome. 5-Bromouracil, when substituted for thymine, did not disturb the sequence of replication nor did it initiate extra replication cycles. By labeling the origin and the terminus of the chromosome with 3H- and 14C-thymine, respectively, it was possible to determine that the rate of chain elongation decreases as the growth rate decreases. No gap in the replication cycle could be observed.
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