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Postgrad Med J. 1977 March; 53(617): 157–158.
PMCID: PMC2496474

Neonatal barbiturate withdrawal.


An infant with neonatal barbiturate withdrawal syndrome is reported. The clinical features, diagnosis and treatment of this condition are discussed. A retrospective review of fifty-three infants of barbiturate-treated epileptic mothers indicated a high incidence of "jitteriness" (17%) and feeding problems (36%) in the immediate neonatal period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bleyer WA, Marshall RE. Barbiturate withdrawal syndrome in a passively addicted infant. JAMA. 1972 Jul 10;221(2):185–186. [PubMed]
  • Brazelton TB. Effect of prenatal drugs on the behavior of the neonate. Am J Psychiatry. 1970 Mar;126(9):1261–1266. [PubMed]
  • Desmond MM, Schwanecke RP, Wilson GS, Yasunaga S, Burgdorff I. Maternal barbiturate utilization and neonatal withdrawal symptomatology. J Pediatr. 1972 Feb;80(2):190–197. [PubMed]
  • Erith MJ. Letter: Withdrawal symptoms in newborn infants of epileptic mothers. Br Med J. 1975 Jul 5;3(5974):40–40. [PMC free article] [PubMed]
  • Hill RM, Verniaud WM, Horning MG, McCulley LB, Morgan NF. Infants exposed in utero to antiepileptic drugs. A prospective study. Am J Dis Child. 1974 May;127(5):645–653. [PubMed]
  • Jalling B, Boréus LO, Kållberg N, Agurell S. Disappearance from the newborn of circulating prenatally administered phenobarbital. Eur J Clin Pharmacol. 1973 Dec;6(4):234–238. [PubMed]
  • Kron RE, Stein M, Goddard KE. Newborn sucking behavior affected by obstetric sedation. Pediatrics. 1966 Jun;37(6):1012–1016. [PubMed]
  • PLOMAN L, PERSSON BH. On the transfer of barbiturates to the human foetus and their accumulation in some of its vital organs. J Obstet Gynaecol Br Emp. 1957 Oct;64(5):706–711. [PubMed]

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