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J Virol. 1990 May; 64(5): 2110–2116.
PMCID: PMC249368

Structure and function of the Epstein-Barr virus BZLF1 protein.


Five DNA-binding sites for the Epstein-Barr virus BZLF1 protein have been identified within three of the early viral promoters, and four of these binding sites contain a consensus AP-1 site. The part of the BZLF1 protein required for sequence-specific DNA binding to one of these AP-1-like sites was identified by deletion mapping. Site-directed mutagenesis of this DNA target suggests that BZLF1 may work partly by overcoming a cellular repressor of viral transcription.

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Selected References

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