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J Virol. Mar 1990; 64(3): 1375–1377.
PMCID: PMC249260
Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
J J Treanor, E L Tierney, S L Zebedee, R A Lamb, and B R Murphy
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Abstract
The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.
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