Search tips
Search criteria 


Logo of jvirolPermissionsJournals.ASM.orgJournalJV ArticleJournal InfoAuthorsReviewers
J Virol. Mar 1990; 64(3): 1375–1377.
PMCID: PMC249260
Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
J J Treanor, E L Tierney, S L Zebedee, R A Lamb, and B R Murphy
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (536K), or click on a page image below to browse page by page.
Articles from Journal of Virology are provided here courtesy of
American Society for Microbiology (ASM)