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Postgrad Med J. 1970 December; 46(542): 698–701.
PMCID: PMC2467126

Acanthocytosis, normolipoproteinaemia and multiple tics


A chronic degenerative neurological disorder is described which is characterized by tics, grimacing, involuntary movements, a severe disturbance of swallowing and a concurrent malformation of the erythrocytes. This condition is clearly different from familial hypo-betalipoproteinaemia and abetalipoproteinaemia, the two previously described neurological disorders associated with abnormal red cells.

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Selected References

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  • Betts JJ, Nicholson JT, Critchley EM. Acanthocytosis with normolipoproteinaemia: biophysical aspects. Postgrad Med J. 1970 Dec;46(542):702–707. [PMC free article] [PubMed]
  • Critchley EM, Clark DB, Wikler A. Acanthocytosis and neurological disorder without betalipoproteinemia. Arch Neurol. 1968 Feb;18(2):134–140. [PubMed]
  • Estes JW, Morley TJ, Levine IM, Emerson CP. A new hereditary acanthocytosis syndrome. Am J Med. 1967 Jun;42(6):868–881. [PubMed]
  • Levine IM, Estes JW, Looney JM. Hereditary neurological disease with acanthocytosis. A new syndrome. Arch Neurol. 1968 Oct;19(4):403–409. [PubMed]
  • Mars H, Lewis LA, Robertson AL, Jr, Butkus A, Williams GH., Jr Familial hypo-beta-lipoproteinemia: a genetic disorder of lipid metabolism with nervous system involvement. Am J Med. 1969 Jun;46(6):886–900. [PubMed]
  • PHILLIPS GB. Quantitative chromatographic analysis of plasma and red blood cell lipids in patients with acanthocytosis. J Lab Clin Med. 1962 Mar;59:357–363. [PubMed]
  • ROVITO DA, PIRONE FJ. Acanthrocytosis associated with schizophrenia. Am J Psychiatry. 1963 Aug;120:182–185. [PubMed]
  • SALT HB, WOLFF OH, LLOYD JK, FOSBROOKE AS, CAMERON AH, HUBBLE DV. On having no beta-lipoprotein. A syndrome comprising a-beta-lipoproteinaemia, acanthocytosis, and steatorrhoea. Lancet. 1960 Aug 13;2(7146):325–329. [PubMed]

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