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Postgrad Med J. 1970 December; 46(542): 702–707.
PMCID: PMC2467113

Acanthocytosis with normolipoproteinaemia: biophysical aspects

Abstract

The electrokinetic properties of normal and pathological red cells and platelets are compared.

The electrophoretic mobilities and isoelectric points of normal and pathological erythrocytes do not differ significantly, adsorption of calcium and uranyl ions occur to the same extent and treatment with neuraminidase induces almost identical mobility decreases.

The pathological platelet-plasma system is more sensitive to adenosine diphosphate (ADP) than normal systems; platelet aggregation and electrophoretic mobility increases are induced by much lower concentrations of ADP than those normally required. The pathological platelet system shows a greater tendency to aggregate spontaneously. The abnormal sensitivity to ADP of the pathological platelet-plasma system is considered in terms of plasma components.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BANGHAM AD, HEARD DH, FLEMANS R, SEAMAN GV. An apparatus for microelectrophoresis of small particles. Nature. 1958 Sep 6;182(4636):642–644. [PubMed]
  • BANGHAM AD, PETHICA BA, SEAMAN GV. The charged groups at the interface of some blood cells. Biochem J. 1958 May;69(1):12–19. [PubMed]
  • Betts JJ, Betts JP, Nicholson JT. Significance of ADP, plasma and platelet concentration in platelet electrophoretic studies. Nature. 1968 Sep 21;219(5160):1280–1282. [PubMed]
  • BRINKHOUS KM, READ MS, MASON RG. PLASMA THROMBOCYTE-AGGLUTINATING ACTIVITY AND FIBRINOGEN. SYNERGISM WITH ADENOSINE DIPHOSPHATE. Lab Invest. 1965 Apr;14:335–342. [PubMed]
  • Bolton CH, Hampton JR, Mitchell JR. Nature of the transferable factor which causes abnormal platelet behaviour in vascular disease. Lancet. 1967 Nov 25;2(7526):1101–1105. [PubMed]
  • COOK GM, HEARD DH, SEAMAN GV. Sialic acids and the electrokinetic charge of the human erythrocyte. Nature. 1961 Jul 1;191:44–47. [PubMed]
  • Critchley EM, Nicholson JT, Betts JJ, Weatherall DJ. Acanthocytosis, normolipoproteinaemia and multiple tics. Postgrad Med J. 1970 Dec;46(542):698–701. [PMC free article] [PubMed]
  • Deykin D, Pritzker CR, Scolnick EM. Plasma co-factors in adenosine diphosphate-induced aggregation of human platelets. Nature. 1965 Oct 16;208(5007):296–298. [PubMed]
  • Farbiszewski R, Skrzydlewski Z, Worowski K. The effect of lipoprotein fractions on adhesiveness and aggregation of blood platelets. Thromb Diath Haemorrh. 1969 Feb 28;21(1):89–92. [PubMed]
  • Hampton JR, Mitchell JR. Abnormalities in platelet behaviour in acute illnesses. Br Med J. 1966 Apr 30;1(5495):1078–1080. [PMC free article] [PubMed]
  • Hampton JR, Mitchell JR. Effect of aggregating agents on the electrophoretic mobility of human platelets. Br Med J. 1966 Apr 30;1(5495):1074–1077. [PMC free article] [PubMed]
  • HASLAM RJ. ROLE OF ADENOSINE DIPHOSPHATE IN THE AGGREGATION OF HUMAN BLOOD-PLATELETS BY THROMBIN AND BY FATTY ACIDS. Nature. 1964 May 23;202:765–768. [PubMed]
  • Manery JF. Effects of Ca ions on membranes. Fed Proc. 1966 Nov-Dec;25(6):1804–1810. [PubMed]
  • Mars H, Lewis LA, Robertson AL, Jr, Butkus A, Williams GH., Jr Familial hypo-beta-lipoproteinemia: a genetic disorder of lipid metabolism with nervous system involvement. Am J Med. 1969 Jun;46(6):886–900. [PubMed]
  • MITCHELL JR, SHARP AA. PLATELET CLUMPING IN VITRO. Br J Haematol. 1964 Jan;10:78–93. [PubMed]
  • SEAMAN GV, KOK D, HEARD DH. The electrophoretic mobility of human red cells re-suspended in their native serum. Clin Sci. 1962 Aug;23:115–123. [PubMed]
  • van Buchem FS, Pol G, de Gier J, Böttcher CJ. Congenital beta-lipoprotein deficiency. Am J Med. 1966 May;40(5):794–804. [PubMed]

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