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Age (Dordr). 2006 June; 28(2): 191–200.
Published online 2006 June 2. doi:  10.1007/s11357-006-9004-x
PMCID: PMC2464722

Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice

Abstract

Since generation of the growth hormone receptor/binding protein (GHR/BP) gene-disrupted mouse nearly 10 years ago, use of this mouse model has become widespread in the elucidation of the physiological roles of GH and insulin-like growth factor-1 (IGF-1). In particular, it serves as a useful model to study mechanisms of aging. This review highlights the evidence demonstrating that the loss of GH signaling leads to lifespan extension in mice, and presents the multiple characteristics of this mouse line that suggest the life extension is due to alteration of the aging process.

Key words: aging, gene disruption, growth hormone receptor/binding protein, longevity, mice

Abbreviations

+/+
wild-type
AMPK
AMP-activated protein kinase
CR
caloric restriction
CREB
cAMP response element-binding protein
Foxo1
forkhead box O1
FSH
follicle stimulating hormone
G6Pase
glucose-6-phosphatase
GHR/BP
growth hormone receptor/ binding protein
GHR/ BP -/-
homozygous for the GHR/BP gene disruption
GLUT4
glucose transporter 4
HI
high isoflavone
IGF-1
insulin-like growth factor-1
IR
insulin receptor
IRS-1
insulin receptor substrate-1
IRS-2
insulin receptor substrate-2
KO
knockout
LH
leutenizing hormone
LI
low isoflavone
MnSOD
manganese superoxide dismutase
MRDT
mortality rate doubling time
PEPCK
phosphoenolpyruvate carboxykinase
PGC-1α
peroxisome proliferator-activated receptor-γ coactivator 1α
PIN
prostatic intraepithelial neoplasia
PPAR
peroxisome proliferator- activated receptor
RXR
retinoid X receptor
T3
triiodothyronine
T4
thyroxine
Tag
large T antigen

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