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Age (Dordr). 2006 June; 28(2): 191–200.
Published online 2006 June 2. doi:  10.1007/s11357-006-9004-x
PMCID: PMC2464722

Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice


Since generation of the growth hormone receptor/binding protein (GHR/BP) gene-disrupted mouse nearly 10 years ago, use of this mouse model has become widespread in the elucidation of the physiological roles of GH and insulin-like growth factor-1 (IGF-1). In particular, it serves as a useful model to study mechanisms of aging. This review highlights the evidence demonstrating that the loss of GH signaling leads to lifespan extension in mice, and presents the multiple characteristics of this mouse line that suggest the life extension is due to alteration of the aging process.

Key words: aging, gene disruption, growth hormone receptor/binding protein, longevity, mice


AMP-activated protein kinase
caloric restriction
cAMP response element-binding protein
forkhead box O1
follicle stimulating hormone
growth hormone receptor/ binding protein
GHR/ BP -/-
homozygous for the GHR/BP gene disruption
glucose transporter 4
high isoflavone
insulin-like growth factor-1
insulin receptor
insulin receptor substrate-1
insulin receptor substrate-2
leutenizing hormone
low isoflavone
manganese superoxide dismutase
mortality rate doubling time
phosphoenolpyruvate carboxykinase
peroxisome proliferator-activated receptor-γ coactivator 1α
prostatic intraepithelial neoplasia
peroxisome proliferator- activated receptor
retinoid X receptor
large T antigen


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