Environ Health Perspect. Jul 2008; 116(7): 948–951.
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Meeting Report: Measuring Endocrine-Sensitive Endpoints within the First Years of Life
1 Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada
2 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
3 University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
4 Harbor-UCLA Medical Center, Torrance, California, USA
5 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
6 University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
7 Columbia University Children’s Center for Environmental Health, New York, New York, USA
8 U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, North Carolina, USA
9 Environmental Health Surveillance Division, Health Canada, Ottawa, Ontario, Canada
10 Neuroscience and Mental Health Program and
11 Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada
12 Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
13 Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada
14 Department of Physiology, University of Toronto, Toronto, Ontario, Canada
15 Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
16 Department of Mechanical Engineering, Technical University of Denmark, Lyngby, Denmark
17 University Male Sterility Center, Toulouse, France
Received January 2, 2008; Accepted April 3, 2008.
A number of pregnancy cohort studies examining the risks of potential endocrine-disrupting chemicals on pregnancy and infant and child health are currently underway in North America and Europe. Given the current interest in the reproductive and developmental effects of endocrine-modulating chemicals and ongoing discussion about the appropriate methods for measuring infant endpoints, consensus is needed on robust and validated methods that can be applied across studies so consistency of results can be evaluated or, where statistical power is limited, data can be pooled. Twenty investigators from Canada, the United States, and Europe attended the workshop “Assessing Endocrine-Related Endpoints within the First Years of Life” (30 April–1 May 2007, Ottawa, Ontario, Canada) and discussed their experiences in measuring endocrine-sensitive endpoints in the first years of life and made recommendations for future research.
The objectives of this workshop were as follows:
- To share data, experiences, and ideas for identifying and measuring postnatal endocrine-sensitive outcomes associated with exposure to environmental chemicals in utero and in early postnatal life, with a focus on a) infant reproductive tract development, b) markers of growth and development, and c) serum hormone levels
- To develop recommendations, if possible, on standardized methods for measuring indicators that would allow comparisons across studies or pooling of data among studies
- To briefly describe methods for measuring neurodevelopmental disorders and sensory dysfunction as well as prenatal and postnatal nutrition, critical cofactors in any study of endocrine-sensitive outcomes (see Supplemental Material online at http://www.ehponline.org/members/2008/11226/suppl.pdf).