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Public Health Rep. 2008 Jul-Aug; 123(4): 504–513.
PMCID: PMC2430647

Economic Benefits of Hepatitis B Vaccination at Sexually Transmitted Disease Clinics in the U.S.



This study assessed the long-term economic implications of a national program to vaccinate all adults treated at sexually transmitted disease (STD) clinics in a single year.


A model was developed to track the long-term disease outcomes and costs among a hypothetical cohort of 2 million STD clinic clients accessing services in one year, using data from published sources and demonstration projects at STD clinics in San Diego (California), Illinois, and Denver (Colorado). The model estimated net economic benefits of a routine hepatitis B vaccination policy at STD clinics nationwide compared with no vaccination.


Without a vaccination program, an estimated 237,021 new hepatitis B virus (HBV) infections would occur over the lifetimes of the 2 million STD clinic clients seen in a single year. HBV-related medical costs and productivity losses would be $1.6 billion. In a national program for routine vaccination at STD clinics, 1.3 million adults would be expected to receive at least one vaccine dose, and an estimated 45% of the new HBV infections expected without vaccination would be prevented. The vaccination program would cost $138 million, HBV infections occurring despite the program would cost $878 million, and clients' time and travel would cost $45 million. The net economic benefit (savings) of routine vaccination would be $526 million. If the indirect costs of lost productivity due to HBV infection are not considered, routine vaccination would have a net cost of $28 million.


Estimates from this model suggest a national program for routine hepatitis B vaccination of adults at STD clinics would be a cost saving to society.

In the U.S., a majority of adult hepatitis B virus (HBV) infections occur through sexual contact among men who have sex with men, heterosexual people with multiple sexual partners, and through the use of contaminated equipment among injection drug users.1,2 Since 1982, hepatitis B vaccination has been recommended for these high-risk groups, but vaccination coverage among them has been low.3,4 To overcome barriers to vaccination, the Advisory Committee on Immunization Practices (ACIP) has endorsed a strategy that includes routine vaccination of all adults at certain public-health venues where most clients are at high risk for HBV infection, including sexually transmitted disease (STD) clinics, human immunodeficiency virus counseling and testing sites, drug-abuse treatment facilities, and correctional facilities.5 Pilot programs in STD clinics demonstrated that hepatitis B vaccination can be feasibly integrated with other STD prevention services when vaccine was available and provided free of charge to clinic clients.69

Publicly funded STD programs operate clinic services for an estimated 1.8 million to 2.2 million individual clients annually (unpublished data, Centers for Disease Control and Prevention).9 Clinics in these programs have the physical infrastructure needed to provide hepatitis B vaccination, but most would require additional funds for vaccine purchase, vaccine administration, staff training, and vaccination record-keeping for a comprehensive vaccination program.7 The costs and benefits of financing such a program have not been adequately addressed, and could be key information for policy makers considering allocating funds for vaccination in these settings. In this study, we estimated the net economic benefits of a hepatitis B vaccination program at public STD clinics nationwide.


Study design

We assumed a national program that would offer hepatitis B vaccine to a cohort of 2 million adult clients at STD clinics in one year and tracked the long-term disease outcomes and costs in a decision model (Figure 1). The model compared two scenarios: (1) no hepatitis B vaccination and (2) universal hepatitis B vaccination. In scenario 1, without vaccination, adults who did not have immunity from prior (resolved) infection or vaccination faced the risk of infection and a fraction of them became infected with HBV over their lifetimes. In scenario 2, vaccination was offered to all adults who did not report prior vaccination. Among adults who received vaccination and did not have immunity from prior infection or vaccination, immunity developed based on the number of doses received and estimated vaccine efficacy after each dose. Adults who did not develop immunity from vaccination, or did not have immunity from prior infection, faced the risk of infection, and a fraction of them became infected. Routine vaccination was expected to lower infections in the client population and reduce cost of illness but add program costs. The net economic benefit of routine vaccination was estimated as the difference in expected societal costs under the two scenarios, discounted to 2005 dollars.10 Discounting accounts for differential timing of costs under the two scenarios.11

Figure 1
Hepatitis B vaccination at STD clinics: decision and Markov models

Disease progression and risk of HBV infection.

Under both scenarios, people with newly acquired HBV infection were followed in a Markov model of natural history of HBV infection (Figure 1).12 We assumed that the majority of adults with a new HBV infection would remain asymptomatic; about 30% would have acute illness that may include jaundice, hospitalization, and fulminant liver failure (FLF); and 6% would develop chronic infection.1315 Of those who developed chronic HBV infection, we assumed the majority would remain asymptomatic, 0.06% would be hospitalized annually for acute exacerbation,16 and 0.5% would develop compensated cirrhosis or hepatocellular carcinoma (HCC) each year.1726 After each year, people with compensated cirrhosis would remain in the same health state or progress. Those whose disease progressed would develop either decompensated cirrhosis or HCC. Patients with FLF, cirrhosis, or HCC would have higher mortality rates compared with the general population. Patients with FLF, decompensated cirrhosis, and HCC were also candidates to receive liver transplantation. Those without infection, with resolved infection, and with chronic hepatitis B but no disease manifestations were assumed to have the same mortality rate as the general population.27 Any of the transitions were permissible to a patient only once during follow-up. We used this model to estimate the long-term outcomes of HBV infection and their costs.

Based on a catalytic model of age-specific prevalence of antibody to hepatitis B-core antigen (anti-HBc) among 300 clients at an STD clinic in San Diego, we estimated the average risk of HBV infection during the remaining lifetime of clinic clients to be about 15%.13,28 Prevaccination testing was not evaluated, as studies had already shown that in populations with HBV infection prevalence lower than 30%, routine vaccination without prevaccination testing was more cost-effective.2932

Routine vaccination at STD clinics.

We assumed a three-dose series of monovalent adult hepatitis B vaccine administered following the recommended schedule would be offered in one year to all clients who did not report prior vaccination.29 Protective immunity would develop among 90% who completed the series, 75% who received two doses, and 40% who received a single dose.3335 We assumed vaccine protection would be lifelong and adverse effects would be negligible.

Based on self-reported prior vaccination, we assumed 90% of adults would be eligible for vaccination, and based on the vaccine acceptance in demonstration projects (Viral Hepatitis Integration Projects, VHIPs) in San Diego, Denver, and Illinois, we assumed 50% to 75% would receive at least one dose of vaccine. Among those who received one dose, 40% to 55% would receive a second dose, and 20% to 30% would complete the series.68,36 Among those who would be offered vaccine, we assumed 16% would be immune from prior infection (based on anti-HBc positivity).28 We assumed that 10% of vaccine would be wasted due to storage and handling.37

Cost of illness.

Lifetime medical cost and productivity loss from HBV infection was estimated from outputs of the Markov model. The model used updated medical cost data for acute and chronic hepatitis B adjusted for inflation (Table 1). Productivity losses from hepatitis B-related excess mortality, adjusted for unemployment rate and inflation, were estimated from median daily wages of the U.S. population.38 All costs were discounted at a 3% annual rate, a standard rate established by the U.S. Panel on Cost-Effectiveness in Health and Medicine.11

Table 1
Base-case parameter estimates of vaccination, and HBV infection and disease, among people treated at STD clinics at age 25

Program costs.

We assumed vaccines would be offered at no charge to clients; the program would purchase vaccine at the U.S. federal contract price (Table 1);39 and the vaccine administration costs would be similar to those incurred in the VHIPs.68,36 Also based on the VHIPs, we included infrastructure costs associated with staff training, supervision, protocol development, and record-keeping associated with vaccination, but excluded the physical infrastructure cost associated with establishing and maintaining clinic facilities.7 All program costs were assumed to occur in the initial year, and, hence, were not discounted. We also included clients' cost of time and travel for the second and third doses of vaccine. We assumed patients would spend a mean of one hour at the clinic at each vaccination visit—the typical time recorded for visits in the San Diego pilot study.28 We also assumed that preparation for a clinic visit would take one hour, and another hour would be spent traveling each way, to and from the clinic. We valued patient time at an average $8.50 per hour, for a total of $34.00 per clinic visit. To estimate the mean cost of patients' time, we assumed 30% of patients at STD clinics are competitive employees, earning $16.13 per hour as estimated from the national monthly data of private average hourly earnings of production workers,40 while 70% earn the minimum wage ($5.15 per hour in 2005).

Base-case and sensitivity analyses

In the U.S., more than 80% of the adults attending STD clinics are 30 years of age or younger.9 To reflect this statistic, we ran the base-case analysis for a cohort aged 25 years. For the Markov model, long-term disease progression rates from published studies were converted to annual rates using the formula p=1-exp(-rt); where p is the long-term rate, r is the annual rate, and t is the time between two health states.41 All base-case parameter values are reported in Table 1. We used univariate sensitivity analysis to examine the impact on model outcomes of changes in the uncertain model parameters. We also carried out threshold analyses of the two variables to which model outcomes were most sensitive, to determine the respective input levels at which medical cost savings alone would just compensate for program costs.


Baseline estimation

In scenario 1, without a vaccination program, the model estimated 237,021 new HBV infections would occur over the lifetime of the 2 million annual STD clinic clients. These new infections would result in 71,106 acute hepatitis B cases and 14,221 cases of chronic HBV infection. Among people with acute hepatitis B, 1,138 would develop FLF, 137 would require liver transplantation, and 848 would die. Among those with chronic HBV infection 2,933 would develop cirrhosis, 917 would develop HCC, 121 would require liver transplantation, and 3,060 would die. The societal cost of HBV infections would be $1,587 million: $346 million in medical costs and $1,241 million in productivity losses (Table 2).

Table 2
Hepatitis B vaccination at STD clinics: expected outcomes and economic implications among 2 million clients

In the first year of a national vaccination program (scenario 2), a total of 1.3 million clients would receive vaccination: 626,040 clients would receive a single dose, 306,360 clients would receive two doses, and 399,600 clients would receive three doses of vaccine. This level of vaccine coverage would prevent 105,828 of the new HBV infections expected without vaccination, a 45% reduction. Reduction in infection would avert 31,748 acute hepatitis B cases and resultant complications, including 508 FLF cases, 61 liver transplantations, and 378 deaths. In addition, 6,350 chronic HBV infections would be prevented, which would avert 1,309 cirrhosis cases, 410 HCC cases, 54 liver transplantations, and 1,366 deaths.

The first year of the vaccination program would require 2,708,400 doses of vaccine (including an estimated 10% wastage) and cost $138 million, including $95 million for vaccine and administration, $30.5 million for staff training and supervision, and $12.2 million for protocol development and vaccination record-keeping. In addition, clients' travel and time for vaccination would cost $45 million. HBV infections that occur despite the vaccination program would cost $879 million, including $192 million in medical costs and $687 million in productivity losses. The total cost of HBV infection and management with a vaccination program is $1,061 million (compared with $1,587 million without vaccination), yielding a net economic benefit of $526 million. If indirect costs of potential productivity losses were excluded from the analysis, the vaccination program would have a net cost of $28 million, or $263 per new HBV infection averted.

Sensitivity analysis

The net economic benefit was most sensitive to changes in the cohort age, risk of infection, proportion of clients receiving at least one dose, and mean daily wage—changing 11% to 17%, with a 10% change from base-case value of any of the parameters. Net economic benefit was relatively less sensitive to changes in vaccine efficacy, rates of receiving dose two and dose three among patients receiving dose one, prevalence of immunity from prior infection (anti-HBc prevalence), proportion of new infections with acute hepatitis B, lifetime risk of chronic HBV infection, annual rate of compensated cirrhosis among people with chronic HBV infection, and the annual discount rate; changing 1% to 9%, with a 10% change in each parameter (Figure 2). Net economic benefit changed less than 1%, with a 10% change in each of the other parameters.

Figure 2
Sensitivity analyses: change in net economic benefit in response to 10% change in model parameter values from base casea

The net economic benefit without productivity losses was relatively more sensitive to all parameter values, with the lifetime risk of HBV infection, and the proportion of STD clients who accept the first dose of vaccine, as the most influential inputs. In a scenario in which lost productivity due to illness was not considered, the net economic benefits increased by 56%, with a 10% increase of either parameter from baseline levels. We determined that medical cost savings alone would be sufficient to compensate for program-related costs if either the lifetime risk of infection among susceptible patients increased by 3% (to 17.7%) or the proportion of STD clinic clients who accept the first dose of vaccine increased by 13% (to 87.3%).


Enhanced disease surveillance in four U.S. counties indicated that 36% of those reported with acute hepatitis B between 1996 and 1998 had been previously treated for an STD.2 This finding provides a strong rationale for vaccinating adults who are provided with health care at STD clinics. Integrating routine hepatitis B vaccination in public STD clinics would require developing a program that provides vaccine, pays for vaccine administration, and trains professionals to administer vaccination. Our estimates indicate that such an undertaking would be economically beneficial to the country. Expenditures on vaccination would decrease long-term disease incidence and avert costs, with a net savings to society of more than $500 million in the program's first year.

Despite the anticipated economic benefit, funding for routine vaccination for adults who are un- or underinsured has been inadequate. Over the past decade, in the absence of a national program, state and local STD programs have developed hepatitis B vaccination programs and sought financing from existing sources with limited success. A 2001 survey of STD programs found that 33% of programs had a policy for hepatitis B vaccination and about 65% of clinics in these program areas offered vaccine.42 However, only 26% offered vaccine to all STD clinic clients, and the lack of vaccine funding was cited as the major barrier to program implementation.43 Thus, STD programs nationwide require substantial additional financing to implement ACIP recommendations for adult hepatitis B vaccination.7


Our analysis has several limitations. First, the model assumes that scale-up vaccination for the target population in one year is feasible. Although the model estimates were based on pilot programs, if program activities could not be scaled up during this time frame, our model may overestimate the benefits of a vaccination program. Second, we expect that sufficient funds would be available in a national program to achieve the level of vaccine compliance assumed in the base case; if lower vaccine completion rates were allowed, both costs and net savings would be lower.44 Our estimated cost of illnesses was conservative because we included productivity loss from mortality only, and excluded antiviral treatment costs for chronic hepatitis B. Both acute and chronic hepatitis B-related illnesses could lead to a patient's inability to work at least in the short term and increase the cost of illness. Also, antiviral treatment costs are likely to increase the costs of illness.45 With higher costs of illness, the net economic benefit of vaccination would be higher. In the absence of a more exact measurement, we also assumed a constant rate of development of both HCC and cirrhosis, likely overestimating the cost of disease by increasing the burden at younger ages. Finally, we did not consider the potential herd-immunity effects of routine vaccination within or outside the cohort, which is likely to make vaccination more cost-effective.46


In the U.S., programs providing routine infant vaccination since 1991 and catch-up adolescent vaccination since 1995 have led to dramatic declines in hepatitis B incidence.1,5,47 Currently, more than 90% of new infections occur among adults, and many of those infected have previously sought health care in venues such as STD clinics, HIV counseling and testing sites, drug abuse treatment facilities, and correctional facilities.1,2,5 National programs that would finance hepatitis B vaccination in these settings can improve vaccination coverage among people at risk for HBV infection, and reduce the burden of hepatitis B among adults in the U.S. As highly immunized cohorts age, vaccinating adults will become a less essential strategy; however, implementing these programs can accelerate elimination of HBV infection among adults until highly immunized cohorts vaccinated through routine infant and adolescent vaccination programs reach adulthood.


This research was supported in part by the Centers for Disease Control and Prevention (CDC) Cooperative Agreements: U50CCU/519083, U50CCU/819041, U50CCU/919053.

The findings and conclusions in this article are those of the authors and do not necessarily reflect the views of CDC.


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