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Postgrad Med J. 1990 October; 66(780): 860–861.
PMCID: PMC2429713

Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control.


We report three patients who had serious disturbance of anticoagulant control while receiving ifosfamide/mesna-containing cytotoxic chemotherapy in association with warfarin. In view of the likely biological potentiation of warfarin by ifosfamide/mesna, close monitoring of anticoagulant control should be performed during the co-administration of these drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Cantwell BM, Carmichael J, Ghani SE, Harris AL. Thromboses and thromboemboli in patients with lymphoma during cytotoxic chemotherapy. BMJ. 1988 Jul 16;297(6642):179–180. [PMC free article] [PubMed]
  • Cantwell BM, Mannix KA, Roberts JT, Ghani SE, Harris AL. Thromboembolic events during combination chemotherapy for germ cell-malignancy. Lancet. 1988 Nov 5;2(8619):1086–1087. [PubMed]
  • Zalupski M, Baker LH. Ifosfamide. J Natl Cancer Inst. 1988 Jun 15;80(8):556–566. [PubMed]
  • Jardine I, Fenselau C, Appler M, Kan MN, Brundrett RB, Colvin M. Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy. Cancer Res. 1978 Feb;38(2):408–415. [PubMed]
  • Donelli MG, Franchi G, Rosso R. The effect of cytotoxic agents on drug metabolism. Eur J Cancer. 1970 Apr;6(2):125–126. [PubMed]
  • Lind MJ, Margison JM, Cerny T, Thatcher N, Wilkinson PM. Comparative pharmacokinetics and alkylating activity of fractionated intravenous and oral ifosfamide in patients with bronchogenic carcinoma. Cancer Res. 1989 Feb 1;49(3):753–757. [PubMed]

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