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Postgrad Med J. 1985 July; 61(717): 593–594.
PMCID: PMC2418305

A clinical trial using co-trimoxazole in an attempt to reduce wound infection rates in dog bite wounds.


One hundred and thirteen patients were entered into a randomized, prospective double-blind, placebo controlled trial to assess the use of co-trimoxazole in reducing wound infections after dog bites. Although there was a reduction in the wound infection rate from 13.8% in the placebo group to 5.5% in the treatment group this did not reach statistical significance (P = 0.135). If hand wounds are considered separately, no infections occurred in the treatment group and a benefit seems likely.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Aghababian RV, Conte JE., Jr Mammalian bite wounds. Ann Emerg Med. 1980 Feb;9(2):79–83. [PubMed]
  • Callaham ML. Treatment of common dog bites: infection risk factors. JACEP. 1978 Mar;7(3):83–87. [PubMed]
  • Callaham M. Dog bite wounds. JAMA. 1980 Nov 21;244(20):2327–2328. [PubMed]
  • Elenbaas RM, McNabney WK, Robinson WK. Prophylactic antibiotics and dog bite wounds. JAMA. 1981 Aug 21;246(8):833–834. [PubMed]
  • Fiala M, Bauer H, Khaleeli M, Giorgio A. Dog bite, Bacteroides infection, coagulopathy, renal microangiopathy. Ann Intern Med. 1977 Aug;87(2):248–249. [PubMed]
  • Jarvis WR, Banko S, Snyder E, Baltimore RS. Pasteurella multocida. Osteomyelitis following dog bites. Am J Dis Child. 1981 Jul;135(7):625–627. [PubMed]
  • Snook R. Dog bites man. Br Med J (Clin Res Ed) 1982 Jan 30;284(6312):293–294. [PMC free article] [PubMed]

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