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J Virol. Mar 1992; 66(3): 1777–1780.
PMCID: PMC240936
Herpesvirus saimiri oncogene STP-C488 encodes a phosphoprotein.
J U Jung and R C Desrosiers
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102.
The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now report that STP-C488 is phosphorylated in vivo. The phosphorylated form, which accounted for about 15% of STP-C488 in transformed cells, migrated slightly more slowly through sodium dodecyl sulfate-polyacrylamide gels than unphosphorylated STP-C488. A serine residue near the amino terminus was shown to be the site of phosphorylation. However, phosphorylation was not required for transformation of Rat-1 cells by STP-C488.
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